Current Aspects of Flavonoids: Their Role in Cancer Treatment

The book comprehensively introduces readers to various aspects of flavonoids, a category of natural metabolites that exhibits various pharmacological effects. It discusses their chemistry, absorption and metabolism, mechanisms of action and toxicology as well as future perspectives for clinical applications, and also provides detailed insights into their anti-cancer properties, since flavonoids are known to modulate tumor-associated intracellular as well as extracellular signaling pathways. The book also highlights the current research on the health effects of selected flavonoids, and their various roles in cancer prevention and treatment. Lastly, the book elucidates nanotechnology-mediated tools to enhance the bioavailability and solubility of flavonoids to improve their bioactivity and pharmacokinetic parameters.

It uniquely highlights the role and mechanistic details of various flavonoids as an anti-cancer agent in various types of cancer It features the cutting-edge research on the role of nanotechnology in improving the bioavailability and solubility of flavonoids It also entails the recent clinical trials conducted using flavonoids in cancer therapy The book comprehensively provides an overview of the various flavonoids, including new sub-classes of flavonoids and various analytical methods used for their quantitative analysis This book describes the chemistry and biosynthetic methods for the synthesis of various flavonoids using the latest software. It also emphasizes on the Structure Activity Relationships (SAR) of different flavonoids

Autorentext
Dr. Hardeep Singh Tuli is an Assistant Professor at the Department of Biotechnology, Maharishi Markandeshwar (Deemed to be University) in India. From 2009 to 2011, he was a lecturer at the Department of Applied Sciences at the Institute of Science and Technology, Klawad, India. He has more than 8 years of teaching and research experience in pharma science, mammalian physiology and natural products. His research focuses on the isolation, characterization and biochemical evaluation of natural metabolites and the evaluation of their anticancer potential. To date he has published more than 50 papers in various peer-reviewed international journals and authored or co-authored a number of book chapters. He has served as a referee for various international journals, including Plos One, Oncotarget, Phytotherapy Research, Tumor Biology, Asian Pacific Journal of Cancer Prevention, Anti Cancer Agents in Medical Chemistry, Archiv der Pharmazie, Journal of Functional Food, Medical Science Monitor, Canadian Journal of Physiology and Pharmacology, Life Sciences, and Research on Chemical Intermediates. One of his published articles was accepted as short news in the Italian publication Laboratorio 2000. He is a member of numerous international scientific societies and organizations.

Inhalt

Chapter 1 . General introduction and sources of flavonoids.- Chapter 2 . Analytical techniques for the identification and quantification of Flavonoids.- Chapter 3 . Chemistry and Synthetic overview of flavonoids.- Chapter 4 . Metal complexation and chemopreventive patent studies of flavonoid.- Chapter 5 . Molecular targets of flavonoids in cancer: recent advances.- Chapter 6 . Absorption and Metabolism of flavonoids.- Chapter 7. Recent trend in flavonoids studies in term of health prospective.- Chapter 8 . Role of nanotechnology in flavonoid mediated anti-cancer therapy.- Chapter 9. Clinical trial of Flavonoids in cancer.

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