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Demonstrating the vital role and utility of MCRs towards heterocyclic chemistry with applications in natural product synthesis, drug molecules, organic synthesis and others, this book is must-read for every synthetic chemists in academia and industry alike.
Autorentext
290 scientific manuscripts in peer reviewed journals and books and has an H-index of 44. Until now 32 PhD-students performed their research under his guidance.
Dr. Upendra K. Sharma received his master degree from Guru Nanak Dev University in 2004 and his PhD degree (2011) in organic chemistry under the supervision of Dr. Arun K. Sinha at CSIR-Institute of Himalayan Bioresource Technology, Palampur, India. Thereafter, he worked as Assistant Professor at National Institute of Technology (NIT), Jalandhar, India. Later on, he joined the research group of Prof. Dr. Erik Van der Eycken, LOMAC, University of Leuven, Belgium as a postdoctoral fellow and until now has published more than 50 research articles in reputed international journals as well as co-edited a Springer series book on Flow Chemistry of Heterocycles. Recently, he has been permanently appointed as Research Expert in LOMAC, Department of Chemistry, KU Leuven. His research interests include the development of new synthetic methods for biologically relevant molecules employing modern methods of synthesis viz. flow chemistry, MCRs, photoredox catalysis and transition metal-catalyzed C-H functionalizations.
Zusammenfassung
Presents a wide-ranging overview of essential topics and recent advances in MCR chemistry
Heterocycles are a central component in natural product chemistry, pharmaceuticals, agrochemicals, and material science. New synthetic methodologies integrating the sequencing of multicomponent reactions (MCRs) are today being used for the rapid synthesis of diversified heterocycles in just one step. Multicomponent Reactions towards Heterocycles presents an up-to-date summary MCR chemistry with a focus on the conjugation between modern synthetic methodologies and MCRs.
Featuring contributions by leaders in the field, this comprehensive resource highlights applications of MCRs in natural products and intermediate synthesis, discusses current trends and future prospects in MCR chemistry, outlines novel multicomponent procedures, and more. The authors provide the practical information required for designing new reaction strategies and mechanisms, covering topics including MCR-based green synthetic methods, cyclization and cycloaddition reactions, heterocycle multicomponent syntheses in a continuous flow, catalytic alkynoyl generation, MCR synthesis of saturated heterocycles, and CH functionalization and multicomponent reactions.
Inhalt
Recent Trends and Future Prospects of MCRs
MCRs Towards Target Oriented Synthesis of Biologically Relevant Heterocycles
Heterogeneous Approaches Towards Heterocycles via MCRs
Asymmetric Synthesis of Heterocycles in a Multicomponent Fashion
Solid-Phase MCRs Towards Heterocyclic Synthesis
Green Synthesis of Heterocycles via MCRs
Heterocycles via more than Four-Component Reactions
Multicomponent Flow-Chemistry Approaches Towards Heterocyclic Synthesis
Recent Trends on Metal-Catalyzed MCRs Towards Heterocycles
C-H Functionalization as an Imperative Tool Towards Multicomponent Synthesis and Functionalization of Heterocycles
Heterocyclic Syntheses via Novel MCRs
A Recent Update on Isocyanides Based MCRs Towards Heterocycles
Applied/Industrial MCR Approaches Towards Drugs and Intermediates
Alkyne and Allene Activation as an Entry to Mutlicomponent Syntheses of Heterocycles
Multicomponent Reaction and Total Synthesis