Recurrent Miscarriages (RM) & Implantation Failure (IF) have remained an enigma to clinicians and researchers. Even after ruling out all possible causative factors, 50-60% cases still remain "Unexplained'. A majority of these so called "Unexplained" cases are now found to have immunological basis.This book is going into the Immunological aspects of these clinical dilemmas, demystifying the role of Immunology and Immunotherapy in RM and IF. The authors have been working in the field of Reproductive Immunology and Immunotherapy for the last 25 years and they have come out with this book combining the international studies with their own experience. The purpose of writing this book is to provide a comprehensive treatise about Immunotherapy, so that it can become an acceptable modality of treatment in cases where it is needed and is effective.The book discusses the basics in Reproductive Immunology. The immunological changes occurring during pregnancy, the role of Cellmediated Immunity (T cells), Humoral Immunity including cytokines is explained. The normal immunological mechanisms protecting the embryo are highlighted and how these mechanisms are disturbed leading to RM and IF, is also explained.The first and the most discussed method of Immunotherapy is Lymphocyte Immunization Therapy (LIT). The book has given a complete overview of LIT, describing how it created euphoria when it was first introduced, how it gradually went into disrepute and how it is now making a comeback. As the authors have personal experience of LIT, the book gives a detailed and complete information about this active form of immunotherapy.The book has a special section on case studies where the authors have given some clinical case reports (including some of their own), who were treated for immunological factor in RM/IF and were treated with Immunotherapy. These cases can be a useful guide to the readers.The book will be useful not only for undergraduate and postgraduate students but also for clinicians in their practice and for researchers for review of developments in the field.

Autorentext

Dr. Mohan Raut, MD, DGO, FCRI (ASRI), received his graduation & post-graduation) from the premier institute Seth G.S Medical College & KEM. Hospital, Mumbai.

He has been in private practice in Obstetrics & Gynaecology for the past 33 years, with special interest in the field of Reproductive Immunology, especially related to Repeated pregnancy loss, recurrent implantation failure and unexplained infertility.

In 1992, Dr. Mohan Raut was a part of the International Multicentric Research Programme in association with Oxford University on the role of Lymphocyte Immunization Therapy (LIT) in Recurrent Miscarriages.

Later, he had been involved in the LIT programme at Sir H.N. Hospital, Mumbai under the guidance of Dr. Usha Krishna.

He has contributed a chapter on Immunotherapy in Repeated Miscarriages in the book "Pregnancy At Risk - Current Concepts" published by FOGSI. He has started India's first reproductive immunology centre, Dr. Raut's Centre for Reproductive Immunology (previously known as ICPRM) with Dr. Mugdha Raut and use a patented process for LIT procedure.

He has published papers and has spoken in National and International conferences on the topic of Immunomodulation in Repeated Miscarriages & Recurrent Implantation Failures.

He has been honoured with many awards for his work in the field of reproductive immunology, including the Prime Time Global Healthcare Excellence Award for work in the field of Immunotherapy (2017).

The American Society of Reproductive Immunology has awarded him Fellowship in Clinical Reproductive Immunology (FCRI) for his work in the field of clinical reproductive immunology.

He is the Guest co-editor of American Journal of Reproductive Immunology (AJRI) and a member of the Editorial board of Journal of Evidence Based Women's Health Journal (EBWHJ), Egypt.

He is the managing trustee of Dr. Raut's Immunotherapy Foundation (a registered charitable trust) and arranges programmes to create awareness about reproductive immunology and provide affordable medical care. Dr. Mugdha Raut is MD, DGO, FCRI (ASRI), received her graduation & post-graduation) from the premier institute Seth G.S Medical College & KEM. Hospital, Mumbai. She was a gold-medalist in her graduation programme.

She has been in private practice in Obstetric & Gynecology for the past 30 years, with special interest in the field of Reproductive Immunology, especially related to Repeated pregnancy loss, recurrent implantation failure and unexplained infertility.

Dr. Mugdha was trained in Infertility under Dr. Mehroo Hansotia at Nowrosjee Wadia Maternity Hospital, Mumbai. She was associated with Dr. Usha Krishna at the K.E.M. Hospital for her work in the field of Repeated Miscarriages & BOH (Bad Obstetric History).

Her passion & vision in the field of Reproductive immunology resulted in the establishment of Dr. Raut's Centre For Reproductive Immunology (previously known as ICPRM), India's first centre in reproductive immunology. The centre uses a patented process for LIT procedure.

She has published papers and has spoken in National and International conferences on the topic of Immunomodulation in Repeated Miscarriages & Recurrent Implantation Failures.

She has been honoured with many awards for his work in the field of reproductive immunology, including the Times of India Healthcare Achievers Award for the innovative work in the field of Reproductive Immunology (2018).

The American Society of Reproductive Immunology has awarded her Fellowship in Clinical Reproductive Immunology (FCRI) for her work in the field of clinical reproductive immunology.

She is a member of the Education Committee of the American Society of Reproductive Immunology (ASRI) and also a member of the Editorial board of Journal of Evidence Based Women's Health Journal (EBWHJ), Egypt.

Dr. Mugdha was awarded by the prestigious Femina magazine as the TOP 10 WOMEN WHO MATTER and was recognised by the prestigious Cosmopolitan magazine as among the TOP 10 INFLUENTIAL WOMEN (March 2014).

She is the trustee of Dr. Raut's Immunotherapy Foundation (a registered charitable trust) which arranges programmes to create awareness about reproductive immunology and provides affordable medical care.