In the three volumes of "Science of Synthesis: Stereoselective Synthesis" expert authors present the best and most reliable methods currently available for the preparation of chiral nonracemic compounds. These methods may be stoichiometric or catalytic, and the latter may include metal, organic, or enzyme catalysis. "Stereoselective Synthesis 3" covers stereoselective pericyclic reactions, cross coupling, and C-H and C-X activation, where the emphasis is on enantioselective reactions using asymmetric catalysts. Examples from the total synthesis of various natural and unnatural targets validate the utility of the various synthetic methods. Specific topics discussed include cycloaddition, cycloisomerization and sigmatropic rearrangement reactions, allylic and -carbonyl functionalization reactions, metal-catalyzed cross-coupling reactions, desymmetrization, fluorination, polymerization and sulfide oxidation reactions. // The content of this e-book was originally published in April 2011.

Zusammenfassung

The major emphasis here is on enantioselective reactions using asymmetric catalysts. Examples from the total synthesis of various natural and unnatural targets validates the utility of the synthetic methods. Specific topics discussed: cycloaddition, cycloisomerization and sigmatropic rearrangement reactions, allylic and carbonyl functionalization reactions, metal-catalyzed cross-coupling reactions, desymmetrization, fluorination, polymerization and sulfide oxidation reactions.

This volume is part of a 3-volume set: Science of Synthesis Stereoselective Synthesis Workbench Edition

Further information about Stereoselective Synthesis (including sample pages and the table of contents)

Inhalt

3.1 [m+n]-Cycloaddition Reactions (Excluding [4+2])
3.2 [4+2]-Cycloaddition Reactions
3.3 [m+n+1]-Carbocyclization Reactions
3.4 [m+n+2]-Carbocyclization Reactions
3.5 Asymmetric Cycloisomerizations
3.6 Ene Reactions
3.7 Sigmatropic Rearrangements
3.8 Electrocyclic Reactions
3.9 Allylic Substitution Reactions
3.10 Isomerizations To Form a Stereogenic Center and Allylic Rearrangements
3.11 Allylic and Benzylic Oxidation
3.12 Mizoroki–Heck Reaction
3.13 C—C Bond Formation by C—H Bond Activation
3.14 Cross Coupling
3.15 Protonation, Alkylation, Arylation, and Vinylation of Enolates
3.16 α-Functionalization of Carbonyl Compounds
3.17 Baeyer–Villiger Reactions
3.18 Ring Opening of Epoxides, Aziridines, and Cyclic Anhydrides
3.19 Acylation of Alcohols and Amines
3.20 Asymmetric Fluorination, Monofluoromethylation, Difluoromethylation, and Trifluoromethylation Reactions
3.21 Stereoselective Polymerization
3.22 Oxidation of Sulfides