Peptides / Porto Carras, Chalkidiki, Greece, Aug. 31Sept. 5, 1986

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Frontmatter -- Preface -- Committees -- The 19th European Peptide Symposium was supported by -- Contents -- In memoriam Karel Jost...

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Fester Einband

Beschreibung

Frontmatter -- Preface -- Committees -- The 19th European Peptide Symposium was supported by -- Contents -- In memoriam Karel Jost -- THE JOSEF RUDINGER MEMORIAL LECTURE: AN INTRODUCTORY NOTE -- PREDICTION OF POTENCY AND RECEPTOR SELECTIVITY OF REGULATORY PEPTIDES: THE MEMBRANE COMPARTMENT CONCEPT FIRST JOSEF RUDINGER MEMORIAL LECTURE -- MAIN LECTURES -- FROM PEPTONES TO PEPTIDES - A HISTORICAL RETROSPECT -- KNOWLEDGE-BASED DESIGN OF NOVEL PEPTIDES -- INSULIN-LIKE GROWTH FACTORS: STRUCTURE-ACTIVITY RELATIONSHIPS -- A. METHODOLOGY OF SYNTHESIS -- PROTECTION -- SELECTIVE REMOVAL OF THE 2BROMOETHYL GROUP IN PEPTIDE SYNTHESIS -- SELECTIVE PROTECTION OF CYSTEINE WITH FERROCENE DERIVATIVES -- ADVANTAGES AND DISADVANTAGES IN THE USE OF FORMIC ACID IN PEPTIDE SYNTHESIS -- DIBENZYL DICARBONATE (Z2O) , A NEW CARBOBENZOXYLATING REAGENT -- APPLICATION OF FLUORENYLMETHYL ESTERS IN THE SYNTHESIS OF VIRAL PROTEIN FRAGMENTS -- ELECTROCHEMICAL CLEAVAGE OF PROTECTING GROUPS -- AMMONOLYSIS MEDIATED SIDE REACTIONS OF ß-T-BUTYL-ASPARTYL PEPTIDES -- THE PHENOTHIAZINYL-(10)-CARBONYL (PC) - RESIDUE, A NOVEL AMINO-PROTECTING GROUP FOR PEPTIDE SYNTHESIS -- TETRACHLOROETHYL MIXED CARBONATES: THEIR USE IN THE SYNTHESIS OF PEPTIDES -- TFMSA/TFA CLEAVAGE AND DEPROTECTION IN SPPS -- COUPLING: INCLUDING RACEMISATION -- IS THERE HOPE THAT FOUR COMPONENT CONDENSATIONS WILL BECOME USEFUL FOR PEPTIDE AND PROTEIN CHEMISTRY ? -- USE OF FMOC AMINO ACID CHLORIDES IN THE SYNTHESIS OF TACHYKININ SEQUENCES AND INVESTIGATION OF THEIR HISTAMINE RELEASING ACTIVITY -- IMPROVED PREPARATION OF CRYSTALLINE N-(9-XANTHYL) AMINO ACID N-CARBOXYANHYDRIDES FOR PEPTIDE SYNTHESIS -- THE OPTIMIZATION OF REACTION CONDITIONS FOR PEPTIDE SYNTHESIS BY MEANS OF N,N-BIS/2-OXO-3-OXAZOLIDINYL/PHOSPHORODIAMIDIC CHLORIDE -- APPLICATION OF MIXED PHOSPHINIC ANHYDRIDES IN FRAGMENT CONDENSATION OF PEPTIDES -- A NEW PRINCIPLE FOR FRAGMENT CONDENSATION OF PEPTIDES -- SYMMETRICAL ANHYDRIDE REARRANGEMENT LEADS TO THREE DIFFERENT DIPEPTIDE PRODUCTS -- POLYMER SUPPORTED PEPTIDE SYNTHESIS -- ESTERS OF FMOC-AMINO ACIDS WITH 3,4,-DIHYDRO-3-HYDROXY-4-OXO-1,2,3-BENZOTRIAZINE. A NEW CLASS OF SELF-INDICATING, ACTIVATED INTERMEDIATES FOR SOLID PHASE SYNTHESIS -- DESIGN OF REAGENTS FOR SOLID PHASE SYNTHESIS -- SYNTHESIS OF THE CARBOHYDRATE-FREE VESPULAKININ 1 BY THE CONTINUOUS FLOW SOLID PHASE PROCEDURE AND BY A COMBINATION OF SOLID PHASE AND SOLUTION SYNTHESIS -- FACILE SOLID-PHASE PREPARATION OF PEPTIDES CONTAINING THE CH2NH PEPTIDE BOND ISOSTERE AND APPLICATION TO THE SYNTHESIS OF SOMATOSTATIN (SRIF) OCTAPEPTIDE ANALOGUES -- SYNTHESIS OF A KARYOPHILIC PEPTIDE COVALENTLY BOUND TO PHOSPHATIDYLETHANOLAMINE -- GEL PHASE 13C NMR INVESTIGATION OF 'HYPER-HIGH LOAD' SOLID (GEL) PHASE SYNTHESIS OF AN LH-RH (1-5) ASSEMBLY -- LIQUID PHASE PEPTIDE SYNTHESIS EMPLOYING A PHENOLIC MODIFICATION OF THE POLYETHYLENE GLYCOL SUPPORT -- A COMPARISON OF DIFFERENT METHODS FOR THE PREPARATION OF BENZHYDRYLAMINE RESINS -- THIOETHER LINKAGES BETWEEN PEPTIDE SYNTHETIC INTERMEDIATES AND SOLID SUPPORTS -- SOLID PHASE COUPLING OF PROTECTED PEPTIDE SEGMENTS. INFLUENCE OF THE POLYMER SUPPORT -- ATTEMPTS AT THE SYNTHESIS OF FOLLICLE STIMULATING HORMONE RELEASING PROTEIN (FRP) -- PEPTIDE CYCLIZATIONS ON POLYMERIC SUPPORTS - SITE ISOLATION VERSUS SITE - SITE INTERACTION -- SOLID PHASE PEPTIDE SYNTHESIS WITH FMOC-AMINO ACIDS AN ALTERNATIVE PROTOCOL -- ENZYMATIC SYNTHESIS. SEMISYNTHESIS. RECOMBINANT SYNTHESIS -- USE OF PROTEASES FOR THE SYNTHESIS OF LH-RH -- BIOSYNTHESIS OF HUMAN INSULIN IN YEAST VIA SINGLE-CHAIN PRECURSORS -- STUDIES ON SYSTEM PROPERTIES INFLUENCING THE PARTITION CONSTANT IN KINETICALLY CONTROLLED ENZYMATIC PEPTIDE SYNTHESIS -- ENZYMATIC SYNTHESIS OF ASPARTAME. A STUDENT EXPERIMENT -- ENZYMATIC SYNTHESIS OP FRAGMENTS OF THE GONADOTROP RELEASING HORMONE MOLECULE WITH LH-RH/FSH-RH ACTIVITY -- NUCLEOPHILE BINDING IN CHYMOTRVPSIN PEPTIDE SYNTHESIS -- SYNTHESIS AND PROPERTIES OF [Hse65, Ala 81], [Hse65 , Leu81 - and [Hse65 ,Val81