Ultrastructural Pathology

Ultrastructural Pathology, Second Edition is a comprehensive reference on electron microscopy of pathologic tissue in animals and humans. Now presented in an atlas format for easier identification of organelles, the text is designed to bridge the gap between what is seen in the electron microscope at the cellular level and what the pathologist encounters in the postmortem room. New to this edition are sections on diagnostic electron microscopy, providing information on specialized technologies for electron microscopy, and invertebrate pathology. Emphasizing comparative pathology, the book explains and integrates all aspects of cellular changes in lesions occurring from natural or experimental disease.

Auteur

Norman F. Cheville, DVM, PhD, is Professor Emeritus of Veterinary Pathology at Iowa State University. Previously, he was Chair of the Department of Veterinary Pathology and Dean of the College of Veterinary Medicine at Iowa State University, and was Chief of Pathology at the National Animal Disease Center in Ames, Iowa.

Résumé
Ultrastructural Pathology

Contenu

Preface xi

Contributors xiii

Prologue xv

Part I: Structural Basis of Cell Injury 3

1 Response to Cellular Injury 5

Acute Cell Swelling 5

Adaptive Responses to Persistent Injury 21

2 Cell Death 33

Necrosis 35

Programmed Cell Death 40

Interplay of Necrosis and PCD 49

Getting Rid of the Dead Cell 52

Endothelial Cell Death 54

3 Cellular Defense and Recovery 61

Plasma Membrane in Recovery 61

Detoxification: Smooth Endoplasmic Reticulum and Peroxisomes 62

Mitochondria in Recovery 63

Nucleoli, DNA, and the Genome in Recovery 64

Proteostasis 67

Autophagy: Removal of Debris 69

Part II: Organelle Pathology 75

4 The Cell Surface 77

The Plasma Membrane 77

Cytoskeleton 86

Intercellular Junctions 97

Surface Structures 101

5 Intracellular Trafficking 109

Endocytosis 109

Phagocytosis 115

Lysosomes and Cytoplasmic Trafficking 116

Exocytosis 118

6 Nucleus, Ribosomes, the Golgi Complex, and Secretion 125

Nucleus 125

Ribosomes 136

Rough Endoplasmic Reticulum 138

Golgi Complex 139

Secretion 142

7 Peroxisomes, Smooth Endoplasmic Reticulum, and Lipids 153

Peroxisomes 153

Smooth Endoplasmic Reticulum 156

Glycogen 161

Lipids 164

Lipoproteins 169

Lipid Metabolism Disorders 173

8 Mitochondria 181

The Normal Mitochondrion 181

Mitochondrial Swelling: Response to Acute Injury 184

Mitochondriopathy of Metabolic and Chronic Diseases 188

Mitochondrial DNA-Based Disorders 193

Part III: Inflammation and Hemostasis 199

9 Endothelium 201

Endothelial Interface with Blood and Perivascular Space 201

Endothelial Thromboresistance vs. Procoagulation 206

Endothelial Response to Hypoxia and Circulatory Dysfunction 208

Inflammation 209

Mast Cell and Basophil Interface with Endothelium 217

Angiogenesis 223

10 Leukocytes and Platelets 231

The Neutrophil 231

Eosinophils 243

Platelets 246

Thrombosis 257

11 The Mononuclear Phagocyte System and Lymphocytes 269

The Monocyte-Macrophage System 269

Dendritic Cells 274

Lymphocytes 283

12 The Extracellular Matrix 295

Collagen Fibers 297

Microfibrils 303

Extracellular Ground Substance 304

Basement Membranes 307

Mucins and Other Barriers 310

Part IV: Infectious Diseases 317

13 Cytopathology of Viral Diseases 319

Family Poxviridae 319

Family Herpesviridae 327

Family Adenoviridae 338

Family Papillomaviridae 343

Family Polyomaviridae 347

Family Parvoviridae 349

Family Iridoviridae 353

Family Asfarviridae 353

Family Hepadnaviridae 354

Family Circoviridae 355

Family Orthomyxoviridae 356

Family Paramyxoviridae 358

Family Rhabdoviridae 366

Family Filoviridae 369

Family Coronaviridae 370

Family Reoviridae 373

Family Arenaviridae 379

Family Togaviridae 381

Family Arteriviridae 384

Family Bornaviridae 386

Family Flaviviridae 386

Family Bunyaviridae 391

Family Birnaviridae 392

Family Nadoviridae 394

Family Picornaviridae 394

Family Caliciviridae 399

Family Astroviridae 401

Family Retroviridae 401

14 Cytopathology of Pathogenic Prokaryotes 425

Structure of the Bacterial Cell 425 Phylum Tenericutes, Ord...