Essentials of Laboratory Animal Science: Principles and Practices

This book comprehensively reviews the anatomy, physiology, genetics and pathology of laboratory animals as well as the principles and practices of using laboratory animals for biomedical research.It covers the design of buildings used for laboratory animals, quality control of laboratory animals, and toxicology, and discusses various animal models used for human diseases. It also highlights aspects, such as handling and restraint and administration of drugs, as well as breeding and feeding of laboratory animals, and provides guidelines for developing meaningful experiments using laboratory animals.Further, the book discusses various alternatives to animal experiments for drug and chemical testing, including their advantages over the current approaches. Lastly, it examines the potential effect of harmful pathogens on the physiology of laboratory animals and discusses the state of art in in vivo imaging techniques.The book is a useful resource for research scientists, laboratory animal veterinarians, and students of laboratory animal medicine.

Auteur
Dr. Ramachandra, S.G. graduated from Bangalore Veterinary College in 1987 and subsequently completed post-graduation and PhD in Veterinary Pharmacology and Toxicology from Bangalore Veterinary College. He has been working in the field of Laboratory Animal Science for the last twenty-nine years and is currently working as Chief Research Scientist and In-charge of the Central Animal Facility at the Indian Institute of Science, Bangalore. He has undergone several advanced trainings on laboratory animal medicine and surgery at USA, Germany, Taiwan and Japan. He is associated with various regulatory authorities such as CPCSEA (Ministry of Animal Husbandry and Dairying, Govt. of India), NGCMA (DST, Govt. of India) etc., as Laboratory Animal expert. He has organized several national and international conferences/ workshops on Laboratory Animal Science. He has established the Laboratory Animal Scientists' Association (LASA) and served as Founder President for nine years (2004-2013). He has also served as Vice President of Asian Federation of Laboratory Animal Science Associations (AFLAS), Japan. Established Journal of Laboratory Animal Science and serving as Editor-in-Chief. He has been nominated as Fellow by the National Academy of Veterinary Science, New Delhi and bestowed with Nakula award by the Karnataka Veterinary Association for his significant contribution in the area of Laboratory Animal Science. He has provided technical guidance in establishment of more than 15 laboratory animal facilities in the country. He is also actively involved in research and developed rapid diagnostics kits for the detection for six different pathogens of laboratory animals. He has published 90 research papers in peer reviewed national and international journals. He has delivered 90 invited lectures at national and international conferences including Germany, Thailand, Korea, China, Srilanka, South Africa, Taiwan and UK.
Dr. Ramesh.S., is currently serving as Professor and Head, Department of Veterinary Pharmacology and Toxicology, Madras Veterinary College, Tamil Nadu Veterinary and Animal Sciences University at Chennai, India. He has a teaching experience of 26 years. He teaches the subjects of pharmacology and toxicology to veterinary graduate, post-graduate and doctoral students. He has so far guided 10 dissertation works. His research interest areas include pharmacokinetics of antibacterial drugs, veterinary drug residues and antimicrobial chemotherapy. He has published about thirty research papers in peer-reviewed journals. He has authored one chapter in a book and brought out practical manuals for students and trainees. He has developed E-learning contents in veterinary pharmacology. He has acquired knowledge and expertise in laboratory animal sciences such as biology, housing, handling, ethics, design, pharmacology and toxicology. Since 2013, he has organized the Certificate Course in Laboratory Animal Sciences at Chennai, India, the only course outside Europe to be accredited by FELASA. He has also developed training modules in laboratory animals catering to research scholars and laboratory animal caretakers. He serves in the editorial of Journal of LASA India and is a member of many scientific societies.
Dr. Nagarajan.P is working as Head, Scientist at Laboratory Animal Facility, National Institute of Immunology, New Delhi, India. Being a veterinarian, he has been working on laboratory animals for more than 20 years. He has vast knowledge and expertise in care, management, breeding and medicine of laboratory animals including genetically modified animals, immunodeficient animal model, humanized animal models and non-human primates that are being used in research. Before joining NII, he worked at Central Drug Research Institute (CDRI) and National University of Singapore (NUS). He had undergone a diverse training in Laboratory animals including imaging modalities and microsurgery abroad. His research interest is on animal models for various diseases and in particular metabolic diseases. He has published more than 35 research articles in peer-reviewed international journals and authored book chapters. He is also serving as a reviewer for various International journals and he is a member of several national and international scientific societies related to laboratory animal science.

Contenu
Chapter 1. Introduction to Laboratory Animal Medicine. Chapter 2. Policies, Principles and regulations Governing the Care and Use of Animal in India. Chapter 3. Ethics and Animal welfare. Chapter 4. Designing of Lab animal facilities. Chapter 5. Quality control of Laboratory animals. Chapter 6. Biostatistics and design of experiments in Laboratory animal science. Chapter 7. Alternatives to animal models. Chapter 8. Anatomy, Physiology and husbandry - Mice and Rat. Chapter 9. Anatomy, Physiology and Husbandry Rabbits and Guinea Pigs. Chapter 10. Genetics and Breeding of Laboratory animals. Chapter 11. Nutrition and feeding in Laboratory animals. Chapter 12. Microbiology and infectious diseases of Laboratory animals. Chapter 13. Pathology of infectious and non-infectious diseases affecting Laboratory animals. Chapter 14. Behaviour of laboratory animals. Chapter 15. Drug administration and collection of blood in rodents and rabbits. Chapter 16. Clinical examination of Rodents and Rabbits. Chapter 17. Anaesthesia, Analgesia and euthanasia in Rodents and Rabbits. Chapter 18. Techniques of animal experimentation: Surgical animal models and Non-invasive techniques. Chapter 19. Bio safety consideration in Lab animal facilities and working on infectious agents. Chapter 20. Histology, Systemic Dissection and Necropsy Techniques, organ collection in Laboratory animals. Chapter 21. Occupational health hazards and disaster management in lab animal facility. Chapter 22. Imaging modalities for preclinical research. Chapter 23. Efficacy studies pathology scoring and digital image analysis of histopathology Images.