Targeted Therapy for the Central Nervous System

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Targeted Therapy for Central Nervous System: Formulation, Clinical Challenges and Regulatory Strategies presents research on various delivery methods of drugs to the central nervous system and brain. This volume examines targeted therapies for neurodegenerative disorders and succinctly outlines the future of drug delivery systems, highlighting significant advancements specifically relating to central nervous system delivery. The current book will be of interest to researchers working in the field of neuroscience and pharmacology as well as clinicians (pharmacists, radiologists, psychiatrists).

Contenu

Part I: Brief about pathophysiology

1. Etiology and treatment challenges for neurodegenerative disorders
2. Etiology and treatment challenges for neurotraumatic and psychiatric disorders
3. Barriers to progress of neurotherapeutics: getting drugs to brain

Part II: Novel formulation strategies for targeted therapy

4. IGF-II conjugated Nano carrier for brain targeting
5. ApoE targeting
6. Transferrin receptor mediated drug delivery
7. Surface engineered multimodal magnetic nanoparticles
8. Tau targeting biomimetic nanoparticles
9. Stem cell therapy
10. SR-B1 receptor targeting
11. BACE-1 and ?-secretase as therapeutic target for AD
12. Minimally Invasive Nasal Depot (MIND) technique for direct BDNF AntagoNAT delivery to the brain
13. Immunosuppressive and immunomodulatory therapies
14. CRISPR/Cas9 gene editing: A new hope for AD
15. Artificial intelligence
16. Carbon dots as versatile nano-architectures for the treatment of neurological disorders

Part III: Clinical challenges and regulatory updates

17. Animal models
18. Medical device
19. Regulation of nano-materials and Nano-medicines for clinical applications
20. Regulatory Considerations for the Use of Biomarkers and Personalized Medicine in CNS Drug Development
21. Regulatory toxicology testing for pharmaceuticals
22. Emerging challenges and opportunities for drug and drug product registration