Polypharmacology

There is a growing interest in unmet needs for the development of a new discipline in drug discovery and in university education on polypharmacology. However, there has not been a book with the comprehensive compilation of basic knowledge and advanced methodology that is needed. This book aims to meet the needs making Polypharmacology a new sub-discipline of Pharmacology, not only being a hot area of pharmacological research and education but also a new paradigm for drug discovery. It contains the contents covering the entire scope of Polypharmacology including systemic in-depth exposition of basic knowledge, novel concepts, innovative technologies, and translational and clinical applications by showcasing state-of-the-art strategies and step-by-step instructions of cutting-edge methods. The contents of this book targets broad readerships including scientists in pharmacology research and drug development, and university teachers and graduates in medical school or school of pharmacy.

Provides comprehensive, in-depth mechanisms behind the knowledge and methodology of Polypharmacology Emphasis on rationally designed Polypharmacology or multi-target, single-drug (MTSD) pharmacology Contains a wide collection of the state-of-the-art Polypharmacology technologies

Auteur

Zhiguo Wang PhD received his PhD in cardiovascular pharmacology from McGill University, Canada. He is presently the Director of the Division of Drug Discovery, Meditech Institute of Research and Advance (USA) and a Distinguished Professor in the Department of Pharmacology, Harbin Medical University. He is an author of over 150 research articles in prestigious scientific journals and of 6 monographs and 15 book chapters with renowned scientific publishers. His research interests cover cardiovascular disease and pharmacology, molecular pharmacology, epigenetic polypharmacology. His research group is one of the earliest investigators who proposed "one drug, multiple targets" polypharmacology concept and provided the experimental evidence in support of the epigenetic polypharmacology.

Contenu
PART I. Polypharmacology as a New Branch of Pharmacology: Concept and Principles.- Basics of Polypharmacology.- Polypharmacology in Clinical Applications: Multitarget Multidrug-combination (MTMD-C).- Polypharmacology in Clinical Applications: Multitarget Multidrug-single-formulation (MTMD-SF).- Polypharmacology in Clinical Applications: Multitarget Single-drug (MTSD).- Polypharmacology in Drug Discovery: Designed Epigenetic MTSD and Small-molecule MTSD.- Anti-cancer Polypharmacology.- Cardiovascular Polypharmacology.- Neuronal Polypharmacology.- Pulmonary Polypharmacology.- Polypharmacology of Metabolic Disease.- Polypharmacology of Infectious Disease.- Polypharmacology of Inflammation.- Anti-psychotics Polypharmacology.- Anti-aging Polypharmacology.- Polypharmacology in Drug Repurposing.- Polypharmacology and Unintended Drug Promiscuity.- Polypharmacology Pharmacokinetics.- The Future of Polypharmacology.- PART II. Polypharmacology in New Drug Development: Strategies and Protocols.- Designed MTSD Discovery Process.- Designed MTSD Discovery Strategies.- Designed MTSD Discovery Technologies.- Designed MTSD Discovery Databases.- Designed MTSD Target Deconvolution.-Designed MTSD Target Validation.- Designed MTSD Lead Identification and Optimization.- Designed MTSD Discovery Protocols.- Natural Products in MTSD Discovery.- Polypharmacology Procedures for Drug Repurposing.- Polypharmacology Procedures for Drug Promiscuity Discovery.