Polymeric Gene Delivery Systems

The series Topics in Current Chemistry Collections presents critical reviews from the journal Topics in Current Chemistry organized in topical volumes. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience.

Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field.
The chapter "Polymeric Nanoparticle-Mediated Gene Delivery for Lung Cancer Treatment" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

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Klappentext

The series Topics in Current Chemistry Collections presents critical reviews from the journal Topics in Current Chemistry organized in topical volumes. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience. Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field. The chapter "Polymeric Nanoparticle-Mediated Gene Delivery for Lung Cancer Treatment" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Inhalt
History of Polymeric Gene Delivery Systems.- PolymerNucleic Acid Interactions.- Polysaccharide-based Nanoparticles for Gene Delivery.- Peptide-Based and Polypeptide-Based Gene Delivery Systems.- Degradable Polyethylenimine-Based Gene Carriers for Cancer Therapy.- Precisely Defined Polymers for Efficient Gene Delivery.- Stimuli-Responsive Polymeric Nanocarriers for Efficient Gene Delivery.- Fabrication of Low-Generation Dendrimers into Nanostructures for Efficient and Nontoxic Gene Delivery.- Polymeric Nanoparticle-Mediated Gene Delivery for Lung Cancer Treatment.- Brain-Targeted Polymers for Gene Delivery in the Treatment of Brain Diseases.- Polymers in the Delivery of siRNA for the Treatment of Virus Infections.- Polymers in the Co-delivery of siRNA and Anticancer Drugs for the Treatment of Drug-resistant Cancers.