Nitric Oxide and the Cardiovascular System

Leading clinical and experimental investigators comprehensively review the chemistry, biochemistry, molecular biology, physiology, and pathophysiology of nitric oxide in the cardiovascular systems. These experts particularly illuminate nitric oxide biology, its cardiovascular pathophysiology, and its role in cardiovascular therapeutics. Topics also included are the development of nitric oxide donors for the treatment of myocardial ischemia and thrombosis, the development of gene therapeutic restoration of endothelial function in atherosclerosis, and the application of nitric oxide biology to investigative arenas in cardiovascular medicine. With its balanced presentation of basic and clinically relevant information, Nitric Oxide and the Cardiovascular System provides a comprehensive, authoritative guide for all those cardiovascular biologists, cardiologists, physiologists, and cardiovascular surgeons engaged in today's clinical or experimental research.

Includes supplementary material: sn.pub/extras

Zusammenfassung
"Many very notable authors in this field have contributed chapters to this book, reads as if written by one author....this book was expertly written and superbly referenced. It really is the book on everything one has always wanted to know and was afraid to ask about nitric oxide. The book is great reading and also a wonderful resource to identify the best references on the basic science and clinical aspects of nitric oxide. It is highly recommended to those who do both bench research and clinical trials involving nitric oxide and its effects on the vasculature." - Annals of Vascular Surgery

"All of these aspects have been thoroughly and thoughtfully addressed by Dr. Joseph Loscalzo and Dr. Joseph Vita, who assembled a truly outstanding group of authorities in the field, to participate in an up-to-date delineation of the physiological and pathophysiological role of nitric oxide in the cardiovascular system, ranging from the regulation of vascular tone to nitric oxide cell signaling, from cardiomyocyte function to cardiac electrophysiology, from leucocyte cell adhesion to fibroblast function." - Cell Biology International

"The lecture of this excellent publication with an important bibliography at the end of each chapter, will provide researchers and clinicians with a concise review of the latest advances in the field of nitric oxide." -Acta Cardiologica

Inhalt
I Biology of Nitric Oxide.- 1 The Biological Chemistry of Nitric Oxide.- 2 Cell and Molecular Biology of Nitric Oxide Synthases.- 3 Cellular Signal Transduction and Nitric Oxide.- 4 Regulation of Gene Expression by Nitric Oxide.- 5 Cytotoxicity, Apoptosis, and Nitric Oxide.- 6 Nitric Oxide and Ion Channels.- 7 Role of Nitric Oxide in Vasomotor Regulation.- 8 Nitric Oxide and Platelet-Mediated Hemostasis.- 9 Nitric Oxide Modulates Leukocyte-Endothelial Cell Adhesion.- 10 Nitric Oxide and Cardiomyocyte Function.- 11 The Fibroblast and Nitric Oxide.- 12 Nitric Oxide in Cardiac Electrophysiology.- II Cardiovascular Pathophysiology of Nitric Oxide.- 13 Nitric Oxide and Endothelial Dysfunction.- 14 Nitric Oxide and Hypertension.- 15 Nitric Oxide and Pulmonary Hypertension.- 16 Nitric Oxide in Atherosclerosis.- 17 Thrombotic Disorders and Nitric Oxide Insufficiency.- 18 Myocardial Nitric Oxide in Heart Failure.- 19 Shock States and Nitric Oxide.- 20 Stroke and Nitric Oxide.- 21 The Role of Nitric Oxide in Ischemia-Reperfusion.- III Nitric Oxide in Cardiovascular Therapeutics.- 22 Nitrovasodilators.- 23 S-Nitrosothiols.- 24 Diazeniumdiolates (Formerly NONOates) in Cardiovascular Research and Potential Clinical Applications.- 25 Inhaled Nitric Oxide Therapy for Acute Respiratory Failure.- 26 Antioxidants and Endothelium-Derived Nitric Oxide Action.- 27 Coating Arterial and Blood-Contacting Surfaces with NO·-Donating Compounds.- 28 Gene Therapy and Nitric Oxide.- 29 Nitric Oxide and Tissue Preservation in Transplantation.- 30 L-Arginine: Its Role in Cardiovascular Therapy.