Molecular Biomarkers for Cancer Diagnosis and Therapy

This book presents recent advancements, challenges, and clinical implications of molecular biomarkers in various cancers. This book highlights the clinical applications of biomarkers are extensive for cancer risk assessment, screening and early detection of cancer, accurate diagnosis, patient prognosis, prediction of response to therapy, and cancer surveillance and monitoring response. It also explores the progress of predictive biomarkers as an adjunctive tool to tumor immunotherapy in effectively identifying the efficacy of immune checkpoint inhibitors and discusses their future directions in achieving precision immuno-oncology. Further, the book examines the combination of next-generation sequencing and advanced computational data analysis approaches in the understanding of the genomic underpinnings of cancer development and progression. Towards the end, the chapter discusses the role of some commonly investigated phytochemicals and their epigenetic targets that are of particularinterest in cancer prevention and cancer therapy. It is a must for researchers as well as advanced students and physicians in the field of cancer and clinical oncologists.

Discusses different applications of cancer biomarkers in clinics Reviews the application of molecular biomarkers in the development of novel cancer therapies Examines future challenges in the evaluation of cancer biomarkers

Autorentext

Professor Ranbir Chander Sobti is Indian National Science A Senior Scientist Indian Academy of Sciences (INSA) and Emeritus Professor at Punjab University. He is a former Vice-Chancellor of the Panjab University, Chandigarh & Babasaheb Bhimrao Ambedkar University (Central University), Lucknow. He started his career as a cytogeneticist and then moved on to molecular biology, including genomics, to understand the susceptibility and disease process of cancer, COPD, AIDS, metabolic syndrome, and kidney diseases. He has also used stem cells and nanoparticles to understand the process of tissue organ development through a designed de-cellularization protocol. He has published more than 350 research articles in the journals of international repute and has also published more than 50 books. He is a Fellow of the Third World Academy of Sciences, National Academy of Sciences India, Indian National Science Academy, National Academy of Medical Sciences, National Academy of Agricultural Sciences, Canadian Academy of Cardiovascular Diseases and few others. He was the General President of the Indian Science Congress for the 102nd session held at the University of Jammu in 2013. Dr. Sobti is the recipient of many prestigious awards like the INSA Young Scientist Medal, UGC Career Award, Punjab Rattan Award, JC Bose Oration and Sriram Oration Awards and of Life Time Achievement Awards of the Punjab Academy of Sciences, Zoological Society of India, and the Environment Academy of India.He is recipient of most prestigious civil award Padmashri of The Government of India

Professor H Sugimura has served as a Chairman and Vice Director, Hammatsu University School of Medicine for 32 years, and now a Professor Emeritus of Hamamatsu University School of Medicine. He had been a President of Japan Cancer Epidemiology and Molecular Epidemiology. He is an internationally recognized cancer biologist, molecular epidemiologist, and molecular pathologist. He had also worked at University of Tokyo and had been visiting fellow at NCI, NIH Bethesda from 1988-1990. He has published a large number of papers in journals of repute with high impact factor. Currently he serves as a Director of Sasaki Institute, a 140 years old renowned cancer institute, Tokyo

Dr. Aastha Sobti is BDS (Panjab University ) ,Masters in Clinical Dentistry (University of London ) and Ph.D (Lund University,Sweden). She carried out her research for Ph.D at the Department of Immunotechnology, Lund University, Lund, Sweden, under CanFaster, Marie Sklodowska-Curie COFUND programme. She has a background in dental sciences and did a specialization in master's in Clinical Dentistry (Oral surgery) from Eastman College, UCL, London. Her core interests are head and neck cancer-based clinical research. In entirety aiding in the field to bring reforms that are required in the present multifarious surgical as well as translational research areas. She has teaching and research experience of about 8 years and published a few papers in international journals of repute. She is a recipient of a large number of prizes and medals for her exceptional work namely the academic certificate of excellence from BAOS, UK and IADR Hatton award (India). Additionally, she has attended and presented papers in international conferences in Hong Kong, Croatia, Brazil, Sweden, UK, Japan, and other countries.

Inhalt

Chapter 1. Molecular Biomarkers of Cancer and their Diagnostic Applications.- Chapter 2. Statistical Models in Cancer Management.- Chapter 3. Deep Learning Techniques for Computer Aided Diagnosis of Various Cancers.- Chapter 4. Machine Learning Techniques in Computer Aided Diagnosis for Effective Detection of Malignant Tissues.- Chapter 5. Molecular Mechanisms of Oncogenesis.- Chapter 6. Application of CRISPR in Cancer Research and Treatment.- Chapter 7. Nanobiosensing Platforms for Early Detection of Cancer.- Chapter 8. Bionanotechnological Strategies and Tools for Cancer Prediction, Prevention and Therapy.- Chapter 9. Central Nervous System Tumors.- Chapter 10. Biomedical Approaches in the Research and Management of Head and Neck Squamous Cell Carcinoma.- Chapter 11. Applications of Molecular Biology and Biomedical Advances in Ocular Oncology.- Chapter 12. Molecular Markers in Oral Cancer.- Chapter 13. MicroRNAs as Tools for Early Diagnosis and Predicting Response to Therapy in Oesophageal Cancer.- Chapter 14. The Role of Complement Regulatory Proteins during Liver Homeostasis and Hepatitis C Virus-related Liver Disease.- Chapter 15. Metabolite based Biosignature of Pancreatic Cancer.- Chapter 16. Molecular Pathogenesis of Lung Cancer: Evolving Landscape based on Past Experience.- Chapter 17. Molecular Insights and Risk Factors Associated with Small and Non-Small Cell Lung Cancer.- Chapter 18. Deciphering the Role of Immune-Checkpoint Inhibitors in Lung Cancer Treatment.- Chapter 19. Bone Tumors: An Overview.- Chapter 20. Genomics in the 'Personalize' Management of Breast Cancer.- Chapter 21. Colorectal Cancer and Role of Biomarkers in Diagnosis, Prognostification and Personalized Treatment.- Chapter 22. Biomarkers in Renal Cell Carcinoma.- Chapter 23. Androgen and Estrogen Signalling Pathways in Prostate Hyperplastic Tissues: Opportunities for Therapeutic Targeting from Multiple Angles.- Chapter 24. Role of Circadian Rhythm in Hormonal Cancers.- Chapter 25. Recent Immunotherapeutic Approaches for Cancer Treatment.- Chapter 26. Importance of Adme for Anticancer Prodrugs.- Chapter 27. Personalized Medicine in Clinical Management of Breast Cancer - Where Do We Stand?.- Chapter 28. PABPC1: A Novel Emerging Target for Cancer Prognostics and Anti-Cancer Therapeutics.- Chapter 29. Recent Update on Pyridoxine Derivatives as Anticancer Agents with Overview on its Patents.- Chapter 30. Recent Advances in Iron Oxide Nanoparticles-based Nano Medicine for Prostate Cancer: A Review.- Chapter 31. Therapeutic Applications of Snake Venom Proteins as Anti-Cancer Agents.- Chapter 32. Revamping Anticancer Strategies by Modulating Tumor Microenvironment using Botanicals.- Chapter 33. Modulation of Epigenetic Regulators for Cancer Prevention by Dietary Phytochemicals: Tools for Personalized Nutrition.