Kidney Development and Disease

Kidney Development and Disease brings together established and young investigators who are leading authorities in nephrology to describe recent advances in three primary areas of research. The first section describes the use of animal models as powerful tools for the discovery of numerous molecular mechanisms regulating kidney development. The second section focuses on nephric cell renewal and differentiation, which lead to diverse cell fates within the developing kidney, and discusses diseases resulting from the aberrant regulation of the balance between cell fate decisions. The final section concentrates on morphogenesis of the developing kidney and its maintenance after formation as well as the diseases resulting from failures in these processes.

Kidney form and function have been extensively studied for centuries, leading to discoveries related to their development and disease. Recent scientific advances in molecular and imaging techniques have broadenedour understanding of nephron development and maintenance as well as the diseases related to these processes.

Highlights recent advances in the three primary areas of kidney research Brings together established and young investigators Written by international experts in the field Includes supplementary material: sn.pub/extras

Klappentext
Kidney Development and Disease brings together established and young investigators who are leading authorities in nephrology to describe recent advances in three primary areas of research. The first section describes the use of animal models as powerful tools for the discovery of numerous molecular mechanisms regulating kidney development. The second section focuses on nephric cell renewal and differentiation, which lead to diverse cell fates within the developing kidney, and discusses diseases resulting from the aberrant regulation of the balance between cell fate decisions. The final section concentrates on morphogenesis of the developing kidney and its maintenance after formation as well as the diseases resulting from failures in these processes. Kidney form and function have been extensively studied for centuries, leading to discoveries related to their development and disease. Recent scientific advances in molecular and imaging techniques have broadened our understanding of nephron development and maintenance as well as the diseases related to these processes.

Inhalt
Part A Model Systems of Kidney Development and Disease.- 1 Drosophila Malpighian tubule: A model for understanding kidney development, function and disease.- 2 Zebrafish pronephros development.- 3 Zebrafish as a model of kidney disease.- 4 Use of Xenopus frogs to study renal development/repair.- Part B Cell Renewal, Differentiation and Fate in Nephrogenesis.- 5 Tissue-specific p53 functions during kidney development.- 6 Growth factor regulation in the nephrogenic zone of the developing kidney.- 7 Development and diseases of the collecting ductsystem.- 8 Origin and function of the renal stroma in health and disease.- Part C Nephron Morphogenesis and Maintenance.- 9 Imaging, analysing and interpreting branching morphogenesis in the developing kidney.- 10 Genetic syndromes affecting kidney development.- 11 Primary cilia in cystic kidney disease.- 12 Inflammation and fibrosis in polycystic kidney disease.- 13 Epithelial to mesenchymal transition (EMT) andendothelial to mesenchymal transition (EndMT): Role and implications in kidney fibrosis.