Gene Transfer and the Ethics of First-in-Human Research

This book examines the ethical and policy dimensions of testing interventions in human beings for the first time. It discusses numerous distinctive ethical challenges encountered in attempting to translate preclinical findings into clinical applications. It is relevant to ethicists, legal practitioners, policy makers, clinical researchers and geneticists.

Informationen zum Autor Jonathan Kimmelman is Assistant Professor, Biomedical Ethics Unit, Social Studies of Medicine, McGill University, Montreal, Quebec, Canada. Klappentext Examines the ethical and policy dimensions of testing novel medical interventions in human beings for the first time. Zusammenfassung This book examines the ethical and policy dimensions of testing interventions in human beings for the first time. It discusses numerous distinctive ethical challenges encountered in attempting to translate preclinical findings into clinical applications. It is relevant to ethicists! legal practitioners! policy makers! clinical researchers and geneticists. Inhaltsverzeichnis Abbreviations; 1. Gene transfer lost in translation: an introduction; 2. What is gene transfer?; 3. Safety, values, and legitimacy: the protean nature of risk in translational trials; 4. Taming uncertainty: risk and gene transfer clinical research; 5. Succor or suckers? Evaluating the benefits of trial participation; 6. Looking backward: a model of value for translational trials; 7. Over the chasm: the initiation of first-in-human trials; 8. Tropic of cancers: gene transfer in resource-poor settings; 9. Great expectations and hard times: managing expectations in gene transfer; 10. Something in the sight adjusts itself: conclusion; Note to readers; Index.

Klappentext

Examines the ethical and policy dimensions of testing novel medical interventions in human beings for the first time.

Inhalt

Abbreviations; 1. Gene transfer lost in translation: an introduction; 2. What is gene transfer?; 3. Safety, values, and legitimacy: the protean nature of risk in translational trials; 4. Taming uncertainty: risk and gene transfer clinical research; 5. Succor or suckers? Evaluating the benefits of trial participation; 6. Looking backward: a model of value for translational trials; 7. Over the chasm: the initiation of first-in-human trials; 8. Tropic of cancers: gene transfer in resource-poor settings; 9. Great expectations and hard times: managing expectations in gene transfer; 10. Something in the sight adjusts itself: conclusion; Note to readers; Index.