Physiology of Inflammation

This book covers the physiological processes relevant to inflammation. Although the problem is addressed from a vascular perspective, pathological aspects are also considered. The book centers on the recruitment of leukocytes to sites of injury and infection, their function in the tissue, and the eventual resolution of inflammation. It starts with the formation of leukocytes and the physiology of their transport to the sites of inflammation, considers endothelial activation, and covers all kinds of leukocyte activators including chemokines. Signal transduction pathways for chemoattractants and the activation of neutrophil functions are discussed. Several chapters review the various adhesion molecules and pertinent methods to study their function, including flow chambers, knockout mice, measurement of soluble adhesion molecules and intravital microscopy. The book is aimed at medical residents, graduate students, postdoctoral fellows, and physicians and scientists in physiology, pharmacology, biomedical engineering, pathology, immunology, infectious disease and related disciplines. It is intended to serve as an advanced textbook or reference for studying the physiology of inflammation.

Klappentext

This book covers the physiological processes relevant to inflammation. It centers on the recruitment of leukocytes to sites of injury and infection, their function in the tissue and the eventual resolution of inflammation.

Inhalt

History of Inflammation Research.- Formation and Differentiation of Leukocytes.- Blood Flow Regulation in Inflammation.- Microvascular Permeability in Inflammation.- Cytokines and Endothelial Cell Activation.- Chemokines and Chemokine Receptors.- Lipid Mediators of Inflammation.- Complement in Inflammation.- Chemoattractant Receptor-G-Protein Coupling.- Antimicrobial Activity of Leukocytes.- In Vitro Flow Models of Leukocyte Adhesion.- Selectins and Their Ligands in Inflammation.- ?2 Integrins and Their Ligands in Inflammation.- VCAM-1 and Its Ligands.-Soluble Leukocyte-Endothelial Adhesion Molecules.- Leukocyte Recruitment as Seen by Intravital Microscopy.- Transmigration of Leukocytes.- Knockout Mice in Inflammation Research.- Interface Between Inflammation and Coagulation.- Coagulation and Fibrinolysis During Endotoxemia and Gram-Negative Sepsis.- Oxygen Radicals in Inflammation.- Nitric Oxide in Inflammation.- Mast Cells in Inflammation.- Resolution of Inflammation.