Oxidative Stress and Toxicity in Reproductive Biology and Medicine

This book discusses the role of oxidative stress in human reproduction with a focus on men's health. The physiological roles of reactive oxygen species (ROS) in male fertility are the focus in this book. This topic is important because oxidative stress is a result of the imbalance between ROS and antioxidants in the body which may lead to sperm damage (DNA or count), deformity, and eventually, male infertility. Therefore, for a better understanding of the molecular mechanisms related to male genotoxicity and its regulation in infertility, this book provides an up-to-date view on the impact of oxidative stress factors in male reproduction .

The main aim of this book is to collect a series of research articles and reviews from a diverse group of scientists to share their research work on the role of ROS or oxidative stress in physiological and pathological states in relation to (in)fertility in the male. This book presents various state-of-the-art chapters of the recent progress in the field of cellular toxicology and clinical manifestations of various issues related to men's health and fertility. Topics include cell signaling, DNA damage and infertility, the pathophysiology of disease instigation and distribution, immune toxicity and prevention.

Autorentext

Dr. Kavindra Kumar Kesari is currently working as Senior Scientist in the Department of Bioproducts and Biosystems, School of Chemical Engineering at the Aalto University, Espoo, Finland. He obtained Doctoral, Master, and Bachelor degrees in Biotechnology from India. He received Junior and Senior Research fellowships during his Doctoral studies at Jawaharlal Nehru University, New Delhi, India. He served as an Assistant Professor position at Jaipur National University, Jaipur, India. He obtained his first Postdoctoral research from University of Eastern Finland, Kuopio, Finland. Currently, he is working on cell ultrastructure study with micro & macro spectroscopic techniques. His work mainly aimed to explore the fundamentals of cell wall ultrastructure of woody & non-woody materials and their applications in biomedical research. His study also explores the medicinal applications of plant derived bioactive compounds and nanoparticles for disease treatment. Kesari, actively involved working in cell and cancer biology research with focus on qualitative and quantitative measurements by applying in vitro, in vivo & biocomputational methods. He is leading researcher of radiation biology. He has developed various methods for animal exposure to radiations and therapeutic measures including brain and reproductive related diseases. Kesari, actively working on the neurological diseases with focus on environmental toxicology and oxidative stress. He has published over 80 papers in reputed scientific journals, 25 book chapters, 5 books and presented over 30 papers at national and international scientific meetings. His Hirsch index (h-index) as of August 2021 is 29 on Google Scholar, 24 on Scopus. Kesari served as subject expert for many International committee and also Editorial board member and reviewer of repute. He has edited special issues in many journals like, Antioxidants and Genes (MDPI) and ESPR (Springer). Kesari has conducted several research projects and guided doctoral students. He has received four times young scientist award and international travel award.

Dr. Shubhadeep Roychoudhury is an Assistant Professor in the Department of Life Science and Bioinformatics, Assam University, Silchar, India. He obtained Master and Doctoral degrees in Biotechnology from Slovakia, Europe with scholarship under Government of India and Government of Slovakia's bilateral cultural exchange program. He completed several Postdoctoral researches including one as a Research Fellow in Andrology/Urology in the American Center for Reproductive Medicine, Department of Urology, Glickman Urological and Kidney Institute, Cleveland Clinic, Ohio, USA. He has been serving as visiting scientist and visiting Professor in institutes of repute including the Pedagogical University in Krakow in Poland, Mendel University in Brno in Czech Republic and Slovak University of Agriculture in Nitra, Slovakia. His teaching and research activities span the fields of reproductive health, reproductive and environmental toxicology, and oxidative stress within the context of male pathophysiology and reproductive dysfunction as well as herbal applications in management. Issues relating to biodiversity and conservation in the context of marginal and eco-sensitive landscapes has been one of his areas of interest. Under his supervision 5 doctoral students have completed their research till date. He has published over 85 research papers in scientific journals, 30 book chapters, 4 books and presented over 50 papers at national and international scientific meetings. His Hirsch index (h-index) is 22 on Google Scholar, 19 on Scopus. He served as a subject expert for many international committees and is also an editorial board member and reviewer of reputed journals. He has edited special issues in many journals including Journal of Environmental Science and Health Part A Toxic/Hazardous Substances and Environmental Engineering (Taylor & Francis), Environmental Science and Pollution Research (Springer Nature). He has conducted several research projects and received young scientist awards.

Inhalt

Content:

1. Oxidative stress and toxicity in reproductive biology and medicine: Historical

perspectives and future horizons in male fertility.............................................

Ralf Henkel

2. Reactive Oxygen Species in the Reproductive System: Sources and

Physiological Roles....................................................................................

Anandan Das and Shubhadeep Roychoudhury

3. Pathological Roles of Reactive Oxygen Species in Male Reproduction....................

Saptaparna Chakraborty and Shubhadeep Roychoudhury

4. Molecular Interactions Associated with Oxidative Stress Mediated Male

Infertility: Sperm and Seminal Plasma Proteomics...........................................

Manesh Kumar Panner Selvam, Damayanthi Durairajanayagam, Suresh C. Sikka

5. Unraveling the Molecular Impact of Sperm DNA Damage on

Human Reproduction............................................................................... Renata Finelli, Bruno P. Moreira, Marco G. Alves, Ashok Agarwal

6. Role of Infection and Leukocytes in Male Infertility..........................................

Shubhadeep Roychoudhury, Sandipan Das, Shatabhisha Roychoudhury, Ashok Agarwal, Ralf Henkel

7. Bacteriospermia and Male Infertility: Role of Oxidative Stress............................ Sandipan Das, Shubhadeep Roychoudhury, Anwesha Dey, Niraj Kumar Jha,

Dhruv Kumar, Shatabhisha Roychoudhury, Petr Slama, Kavindra Kumar Kesari

8. Oxidant-Sensitive Inflammatory Pathways and Male Reproductive Functions.........

Sulagna Dutta, Pallav Sengupta, Srikumar Chakravarthi

9. Oxidative Stress and Idiopathic Male Infertility...............................................

Pallav Sengupta, Shubhadeep Roychoudhury, Monika Nath and Sulagna Dutta

10. Oxidative Stress and Varicocele-Associated Male Infertility...............................

Terence Chun-Ting LAI, Shubhadeep Roychoudhury and Chak-Lam CHO

11. Oxidative Stress in Men with Obesity, Metabolic Syndrome and Type 2

Diabetes Mellitus: Mechanisms and Management of Reproductive Dysfunction.......

Kristian Leisegang

12. Metabolic dysregulation and sperm motility in male infertility............................

Sujata Maurya, Kavindra Kumar Kesari, Shubhadeep Roychoudhury,

Jayaramulu Kolleboyina, Niraj Kumar Jha, Saurabh Kumar Jha, Ankur Sharma,

Arun Kumar, Brijesh Rathi, Dhruv Kumar

13. Tale of viruses in male infertility.................................................................. Shreya D…