Discovery and Development of Therapeutics from Natural Products Against Neglected Tropical Diseases

Discovery and Development of Therapeutics from Natural Products against Neglected Tropical Diseases draws together research on medicinal agents from natural sources as starting points for the design of drugs against Neglected Tropical Diseases (NTDs). From the prediction of promising leads and identification of active agents, to the extraction of complex molecules, the book explores novel, economical and efficacious therapeutics for these diseases. It describes current research and the role of natural products, antimalarial compounds from marine natural products and sesquiterpene lactones, natural antileprotic agents, natural products with potential against Leishmaniasis, Trypanosomiasis and Dengue, and more.

In addition, Quinoline and Isoquinoline alkaloids for developing new antiprotozoal agents are discussed, alongside anti-trypanosomatid heterocyclic compounds as structures for development. Combining the expertise of specialists from around the world, this volume aims to support and encourage researchers in the investigation of natural sources as starting points for the development of novel, safe and effective agents for use against neglected tropical diseases.

• Includes chapters written by active researchers and leading global experts deeply engaged in the research field of natural product chemistry for drug discovery
• Draws together cutting-edge research advances in natural product chemistry that are targeted at neglected tropical diseases
• Highlights the future potential of natural products as sources of novel medicinal compounds against neglected tropical diseases

Inhalt

1. Therapeutics from Natural Products against Neglected Tropical Diseases: An Overview 2. Marine Natural Products as Strategic Prototypes in the Development of a New Generation of Antimalarial Agents 3. Sesquiterpene Lactones: A Versatile Class of Structurally Diverse Natural Products and Their Semisynthetic Analogs as Potential Antimalarials 4. Natural and Synthetic Quinoline Molecules against Tropical Parasitic Pathologies: An Analysis of Activity and Structural Evolution for Developing New Quinoline-based Antiprotozoal Agents 5. Promising Trypanocidal Heterocyclic Compounds of Natural Origin and Their Synthetic Analogs 6. Oxidative Stress in Schistosomiasis, Echinococcosis, and Trypanosomiasis: A Therapeutic Approach 7. Plant Derived Compounds against Protozoan Neglected Diseases: Towards Sustainable Drug Development 8. Leishmaniasis Control: Limitations of Current Drugs and Prospects of Natural Products 9. Natural Antileprotic Agents: A Boon for the Management of Leprosy 10. Aloe Vera: A Promising Hope Against Buruli Ulcer 11. Plant and Marine Products: A Promising Hope in Search of Therapeutics Against Dengue 12. Total Synthetic Approaches for Lucidone - A Promising Natural Lead Candidate Against Dengue Infection