Age-Related Macular Degeneration

Age-related macular degeneration (ARMD) is a frequent disease of the elderly and the most common cause of blindness. During the past decade a variety of therapeutic options have been developed and made available for clinical use. Research results are maturing, but to date the interested reader has had to trawl the many journals of ophthalmology and radiotherapy to acquire relevant information. This book is designed to rectify this situation by providing a comprehensive report on the current forms of treatment for ARMD. After an introductory section on the diagnosis and features of ARMD, individual chapters written by internationally recognized experts document in detail the scientific fundamentals of radiotherapy and ophthalmic surgery, the treatment techniques, potential side-effects, and outcome. Several international study groups report the results of clinical research, focussing on the effectiveness of both radiotherapy and surgery. Special radiotherapy techiques such as proton beam therapy and brachytherapy are described, and their merits and disadvantages discussed. This unique book will be of immense value to all with interest in ARMD.

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Diagnosis and Clinical Features 1 Age-Related Macular Degeneration:Current Concepts of Pathogenesis and Risk Factors - F. SCHüTT and F.G. HOLZ 2 Clinical Manifestations and Natural History of Age-Related Macular Degeneration (ARMD) - J. ZURDEL and G. RICHARD 3 Diagnostic Workup - A. HASSENSTEIN and G. RICHARD 4 Planimetry of Age-Related Macular Degeneration (ARMD) - R. SCHWARTZ Surgery of Age-Related Macular Degeneration (ARMD) 5 Surgery - Overview - J. ZURDEL and K. ENGELMANN 6 Limited Macular Translocation in Age-Related Macular Degeneration (ARMD) - K.-G. AU EONG, D.J. PIERAMICI, G.Y. FUJII, and E.DE JUAN 7 Development of Microelectronic Visual Implant - H.GERDING, S. TANERI, C.E. UHLIG, and K. KRAUSE 8 Transplantation of Retinal Pigment Epithelium Cells - M.VALTINK, J. WEICHEL, G. RICHARD, and K. ENGELMANN Radiotherapy of Age-Related Macular Degeneration (ARMD) - Long-Term Results 9 Radiation Biology of CNV of AMD - U. CHAKRAVARTHY and S.B. KLEIN 10 Principles and Technique of Radiation Therapy - U. HöLLER and W.E. ALBERTI 11 Radiation Effects on the Eye - L.W. BRADY and T.E. YAEGER 12 Long-Term Results of Radiotherapy of Age-Related Macular Degeneration (ARMD) - G.J. BERGINK, C.B. HOYNG, R.W.M. VAN DER MAAZEN, J.R. VINGERLING, W.A.J. VAN DAAL, and A.F. DEUTMANN 13 External Beam Radiation Therapy for Age-Related Macular Degeneration; Two-Year Results - R.H. SAGERMAN and S. GORTY 14 Virtual 3D CT Simulation of Radiotherapy for Exsudative Age-Related Macular Degeneration (ARMD) - P. NIEHOFF, N. KOVACS, and G. KOVACS 15 Radiation Therapy for Age-Related Macular Degeneration - A Wet Type Summary - L.W. BRADY, J.E. LAHANIATIS, J.E. FREIRE, C.T. MIYAMOTO, B. MICAILY, and T.E. YAEGER 16 External Beam Radiotherapy in Age-Related Macular Degeneration - An Uneffective Approach? - S. STAAR, R.KROFF, M. KOCHER, R.-P. MüLLER, and K. HEIMANN Clinical Studies of Age-Related Macular Degeneration (ARMD) 17 A Prospective, Randomized, Double-Blind Multicenter Trial on RadiationTherapy of Age-Related Macular Degeneration (RAD-Study) - C. BELLMANN, K. UNNEBRINK, J. DEBUS, R. ENGENHARDT-CABILLIC, and F.G. HOLZ 18 External Beam Radiotherapy as a Treatment for Subfoveal CNV of AMD - U. CHAKRAVARTHY 19 Long Term Results of High Dose of External Radiotherapy for Age-Related Macular Degeneration (ARMD) with Subfoveolar Neovascularization - M. MAUGET-FAYSEE, R. COQUARD, J.-P. GERARD, and P. MARTIN 20 Low-Dose Radiotherapy for Age-Related Macular Degeneration with Subfoveal Choroidal Neovascularization: Update of Results of the Prospective Randomized St. Gallen Study Trial - C. VALMAGGIA, G. RIES, P. COSSMANN, P. BISCHOFF, and H. NIEDERBERGER Special Radiotherapy Techniques 21 Brachytherapy for Macular Degeneration Associated with Subretinal Neovascularization - P. FINGER, I. IMMONEN, I. FREIRE, and G. BROWN 22 Proton Radiation Therapy of Age-Related Macular Degeneration - L.T. YONEMOTO, J.D. SLATER, P. BLACHARSKI, and J.M. SLATER 23 Various Therapeutic Regimens in Proton Beam Irradiation of Neovascular Membranes in Age-Related Macular Degeneration (ARMD) - E. EGGER, L. ZOGRAFOS, A. SCHALENBOURG, and G. GOITEIN 24 Radiation Therapy of Age-Related Degeneration - W.C. SHEILS, S.Y. LEE, and D.M. MARCUS Subject Index List of Contributors