Zurich, Switzerland, September 3-8, 1989

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Résumé
Frontmatter -- Preface -- Adrien Albert -- Alois Niederwieser -- Tetsuo Shiota -- Contents -- I CHEMISTRY OF PTERINS AND FOLATES -- Recent progress in pteridine chemistry -- Synthesis of pteridines for immunoassay of biopterin and neopterin isomers -- Design of new mechanism-based substrates for dihydrofolate reductase -- New methods for the synthesis of quinazoline antifolates and poly-y-glutamyl metabolites of folates and antifolates -- The decay of quinoid- and 7,8-dihydropterins -- Synthesis of 6-acetyl-2,4-diamino-7,8-dihydro-9//-pyrimido-[4,5-b][l,4]- diazepine, an amino analog of 6-acetyldihydrohomopterin -- Synthetic approaches to methanopterin -- Synthesis and properties of tetrahydropterins coupled to 1,4-dihydropyridines -- A new synthesis of biopterin and some analogues from epoxyaldehydes -- Synthetic studies on the molybdenum cofactor -- A new regiospecific synthesis of anapterin and primapterin -- A novel and efficient synthesis of folylpolyglutamates -- Reaction of acidic anhydride and pyridine with folic acid and classical antifolates -- Quinazoline antifolate thymidylate synthase inhibitors: Synthesis of analogues containing heterocyclic isosteres of the para-aminobenzoate unit -- Synthesis of tetrahydro-8-deazabiopterin -- Synthesis and enzymic properties of new mechanism based substrates for dihydrofolate reductase of the 8-substituted pterin class. -- Imidazolines as carbon-transfer vehicles: models of the tetrahydrofolate (and other) coenzymes -- Asymmetric synthesis and absolute configuration of 5,10-dideaza- 5,6,7,8-tetrahydropteroic acid and 5,10-dideaza-5,6,7,8-tetrahydrofolic acid -- Synthesis and biological evaluation of a fluorescent analogue of folic acid -- Metal complexes of tetrahydroneopterin -- Syntheses of lipophilic analogues of 2-desamino-2-CH3-NIO-propargyl- 5,8-dideazafolate targeted at the enzyme thymidylate synthase (TS). -- Studies in models of folate cofactors: oxidation of 5-methyltetrahydropterin revisited. -- New strategy in the synthesis of neopterin phosphates -- First regiospecific synthesis of 7-iso-D-neopterin and 7-iso-D-neopterin- 3 '-monophosphate -- II. ANALYSIS OF PTERINS AND FOLATES -- Detection of pterins in biological material using mass spectrometry -- Mass spectrometric methods for the structural determination of pteridines and folic acid derivatives -- Structural characterization of underivatized pteridines by laser desorption fourier transform mass spectrometry -- New immunoassays for determination of biopterin and neopterin in body fluids -- A new immunoassay for neopterin and biopterin -- Enzyme immunoassay for urinary neopterin -- A competitive enzyme linked ligand sorbent assay (ELLSA) for quantitation of erythrocyte folates -- Preparation of a bovine serum albumin based chiral matrix for resolution of (6R,S)-N5-formyltetrahydrofolate. -- Rp-HPLC methods for the isolation and chemical identification of pterins from monocytic blood cells -- Cyclodextrin based HPLC separation of 6-S and 6-R diastereomers of 5,10-dideaza and 5-deazatetrahydrofolates. -- Analysis of folate and antifolate metabolites by mass spectrometry -- A critical assessment of methods for measuring folate in human serum and red blood cells. -- HPLC analysis of intracellular folate compounds after enzymic conversion to the corresponding pteroates -- III. BIOSYNTHESIS AND BIOCHEMISTRY OF PTERINS -- The Gowland Hopkins Lecture: Biosynthesis of H4biopterin and related compounds -- The structure ofq-Bh2 - chemistry and biochemistry -- Pteridines in riboflavin biosynthesis -- Pteridine mimicking antibodies -- 6-Pyruvoyl-tetrahydropterin reductases -- Analysis of 6-pyruvoyl tetrahydropterin synthase, a target gene product of su(s) suppressor in Drosophila -- Synthesis of fluorinated 8-ribityllumazines as "F NMR probes and potential inhibitors of the light riboflavin synthase of Bacillus subtilis -- Studies on the oxidation state and biosynthesis of molybdopterin -- Molybdenum cofactor genes in Drosophila -- DNA photolyase: role of pterin in DNA repair. -- 7-Substituted pterins, a new class of mammalian pteridines -- Methanopterin: A structural and functional folic acid analogon in the biochemistry of methanogenic bacteria. -- Biosynthesis of methanopterin -- Tetrahydrobiopterin is required for the oxidation of arginine to nitric oxide by macrophages. -- Biosynthesis of 7-hydroxybiopterin -- GTP cyclohydrolase I from Escherichia coli. Molecular cloning and crystallization -- Molecular characterization of the GTP cyclohydrolase I gene of Drosophila: analysis of cDNA clones -- Inhibitors of bovine adrenal medullary sepiapterin reductase -- Catalytic implication of the reductase and isomerase activity of sepiapterin reductase in the biosynthesis of tetrahydrobiopterin -- Purification and characterization of sepiapterin reductase from human liver -- Biosynthesis of methanopterin and deazaflavin in Methanobacterium thermoautotrophicum -- Studies on riboflavin synthases of Bacillus su...