Admixture Dynamics, Natural Selection and Diseases in Admixed Populations

In this thesis, Dr. Jin presents the distribution of ancestral chromosomal segments in the admixed genome, which could provide the information needed to explore population admixture dynamics. The author derives accurate population histories of African Americans and Mexicans using genome-wide single nucleotide polymorphisms (SNPs) data. Mapping the genetic background facilitates the study of natural selection in the admixed population, and the author identifies the signals of selection in African Americans since their African ancestors left for America. He further demonstrates that many of the selection signals were associated with African American-specific high-risk diseases such as prostate cancer and hypertension, suggesting an important role these disease-related genes might have played in adapting to their new environment. Lastly, the author reveals the complexity of natural selection in shapinghuman susceptibility to disease. The thesis significantly advances our understanding of the recent population admixture, adaptation to local environment and its health implications.

Auteur
Wenfei Jin obtained his Ph.D. from Shanghai Institute of Biological Sciences (SIBS), Chinese Academy of Sciences (CAS). He was supervised by Prof. Li Jin from Fudan University and Prof. Shuhua Xu from SIBS. During his Ph.D. study, Wenfei Jin published 11 research articles, of which 6 articles are as first or co-first author. He received SIBS-Eli Lilly Outstanding Ph.D. Thesis Awards from Eli Lilly, China, in 2012, and won the Excellent Doctoral Dissertation of CAS in 2013. Dr. Wenfei Jin is now a visiting fellow at NHLBI, National Institute of Health in the USA.

Contenu
Introduction.- Distribution of length of ancestral chromosomal segments in admixed genomes.- Exploring population admixture dynamics via distribution of LACS.- Genome-wide search for signatures of natural selection in African Americans.- Complex selective forces shaping the genes underlying human diseases.- Materials and Methods