Translational Autoimmunity, Volume 3

Translational Autoimmunity: Autoimmune Diseases in Different Clinical Settings addresses autoimmunity and associated conditions, such as aging, infectious diseases, cancer, neurodegeneration, psychological disorders, fertility, inflammatory vascular diseases, and interstitial lung diseases. The book addresses sufficiently basic questions on how the immune system is designed to distinguish self from no self and behave such that it's able to maintain self-tolerance, how does it work in infections, and how it elicits an auto-reactive state and develops self-antigens seen in autoimmune conditions.

This is followed by an overview on the genetic and clinical aspects of the spectrum of autoimmune diseases which are broadly categorized into two types of organ specific autoimmune diseases and non-organ specific autoimmune diseases (also known as systemic autoimmune diseases).

• Covers clinical aspects of autoimmunity and translational immunology studies in autoimmunity in different clinical settings
• Meets the needs of basic scientists, clinicians, translational scientists and industry partners
• Supported by a systematic appraisal of the most recent evidence

Contenu

1. Introduction on autoimmunity and associated conditions
   
   2. Crosstalks between autoimmunity and cancer
   3. Autoinmmunity regulation within the tumor microenvironment
   4. Mechanisms of immune tolerance breakdown in inborn errors of immunity
   5. Autoimmunity in classic combined immunodeficiencies
   6. Selective IgM deficiency and autoimmunity
   7. Evans syndrome at crossroads of immune deficiency and immune dysregulation
   8. Autoimmunity and HIV infection
   9. M. paratubeculosis (MAP) as a zoonotic pathogen that provokes autoimmunity via molecular mimicry
   10. Autoimmune diseases and metabolic disorders: molecular connections and potential therapeutic targets
   11. Autoimmunity and infertility
   12. Autoimmunity and its influence on human male infertility- A multi parameter approach
   13. Autoimmunity and its correlation to inflammatory vascular diseases
   14. Autoimmunity in atherosclerosis
   15. Allergy and autoimmunity: share of genetics and environment
   16. Asthma and autoimmunity
   17. Autoimmunity in interstitial lung diseases
   18. Role of autoimmunity in the pathogenesis of chronic obstructive pulmonary disease and pulmonary emphysema
   19. Autoinflammation and cystic fibrosis
   20. Autoimmunity and psychosis
   21. Autoimmunity and chronic urticaria
   22. Translational immunology in immune mediated oral diseases
   23. Oxidative stress in oral autoimmune disorders