Transcription Factors

With contributions by numerous experts

Texte du rabat

With contributions by numerous experts

Contenu

Part 1: An Introduction to Transcription Factors.- Mechanisms of Transcriptional Activation In Eukaryotes. Multiple Mechanisms of Transcriptional Repression in Eukaryotes. Genomics and Transcription Factors.- Part 2: Transcription Factors in Pathophysiology.- Biological Roles of STAT Family in Cytokine Signalling . Members of the T-Cell Factor Family of DNA Binding Proteins and Their Roles in Tumorigenesis. Transcription Factors in the Control of Tumor Development and Progression by TGF-ß Signalling. The p53 Transcription Factor as Therapeutic Target in Cancer. The Role of Ets Transcription Factors in Mediating Cellular Transformation. Function of E2F-Transcription Factor Family During Normal and Pathological Growth. c-Myc in Cellular Transformation and Cancer. Critical Regulator of Inflammation and the Immune Response. Hepatitis B Virus X Protein (HBx): Structure-Function Relationships and Role in Viral Pathogenesis. Regulation of Xenobiotic detoxification by PXR, CAR, GR, VDR and SHP Receptors: Consequences in Physiology.- Part 3: Exogenous Control of Transcription Factor Activity.- Potential of Transcription Factor Decoy OligonucleotidesaAs Therapeutic Approach. Selective Estrogen Receptor Modulators (SERMs) as Therapeutic Agents in Breast Cancer Treatment. Artificial Zinc Finger Peptides: A Promising Tool in Biotechnology and Medicine. Tetracycline-Controlled Transactivators and Their Potential Use in Gene Therapy Applications. Modulating Transcription With Artificial Regulators.