Toxicology of Nanoparticles and Nanomaterials in Human, Terrestrial and Aquatic Systems

Toxicology of Nanoparticles and Nanomaterials in Human, Terrestrial and Aquatic Systems An indispensable compendium detailing the toxicology of nanoparticles with a focus on mechanisms, emerging issues, and new approaches Toxicology of Nanoparticles and Nanomaterials in Human, Terrestrial and Aquatic Systems provides authoritative information on the toxicology of ultrafine and nanoparticulate matter that contaminate terrestrial or aquatic environments and present unique challenges in applied public health and toxicological research. Detailed chapters by a panel of world-renowned experts examine the complementary and dynamic interdependence of aquatic, terrestrial, and human systems and the toxicological impacts on exposure to engineered and manufactured nanoparticles and nanomaterials. Organized into four sections, the book opens with a thorough overview of the field, including known challenges and the necessity for current research activity. The second section describes terrestrial and aquatic systems and the ecotoxicological impact of nanomaterials, followed by critical analysis of the many human health effects of nanomaterials. The book concludes with an in-depth discussion of current gaps in knowledge, future directions, new approach methodologies, alternatives to animal models, and the emerging environmental threat from nanoplastics. Presenting case exemplars of the ecotoxicological impact of nanoparticles in aquatic and terrestrial systems, this important resource:

• Presents in-depth coverage of ecosafety, environmental behavior, fate and transport, interactive effects with other contaminants, and current challenges in soil nano-ecotoxicology
• Addresses rising concerns regarding air pollution and neurological disorders, and the roles played by the gastrointestinal system, the mucosal microbiome, and the immunotoxicology and vasculotoxicity of metal-based nanoparticles
• Provides detailed coverage of nanomaterial health effects from both animal and in vitro models, including the gut microbiome, innate immunity, neurological and cardiovascular impacts, mechanisms of action, and hazard characterization
• Analyzes key topics in ecological nanotoxicology such as environmental micro- and nano-plastic pollution and applied risk assessment Toxicology of Nanoparticles and Nanomaterials in Human, Terrestrial and Aquatic Systems is essential reading for toxicologists, applied biologists, ecotoxicologists, research scientists, medical professionals, regulators, and advanced students in fields such as public health, environmental ecotoxicology and medicine, immunotoxicology, neurotoxicology, cardiovascular and systems biology, hazard identification, and risk assessment.

Marc A. Williams, PhD, is an immunotoxicologist and Project Manager for Ecotoxicological Assessment, U.S. Army Public Health Center, Directorate of Toxicology, Aberdeen Proving Ground, Maryland. He is the author of more than 100 peer-reviewed articles, papers, book chapters, book titles, and scientific reports, with research interests in environmental toxicology, nanotoxicology, immunotoxicology and public health. Dr Williams is the Editor-in-Chief of Drug and Chemical Toxicology and a regular editor for Toxicology Letters.