Thyroid Hormones

Hormonal Proteins and Peptides, Volume VI: Thyroid Hormones is a compilation of papers that details the various aspects, chemical properties, effects, and history of thyroid hormones.
The book covers a wide range of topics related to the study of thyroid hormones. Six chapters are devoted to the various aspects of thyroid hormones. Chapter 1 deals with the chemistry of human thyrotropin. Chapters 2 and 3 survey the chemistry of thyroid hormones and analogs, focusing on synthesis and structure-activity relationships. Chapter 4 presents thyroxin action and the possible direct participation of thyroxin in catecholamine pathways in the nervous system. Chapter 5 discusses the thyroid hormone action during amphibian metamorphosis at the cellular and molecular levels. An account of the evolution of the thyroid function is given in Chapter 6. The final chapter delves on the historical aspect of thyroid hormones.
Biochemists, physicians, pharmacologists, researchers, and students in the medical field will benefit from this book.

Contenu

List of Contributors
Preface
Contents of Previous Volumes

1. Chemistry of Human Pituitary Thyrotropin
   I. Introduction
   II. Isolation Procedures
   III. Chemical and Physical Characteristics
   IV. Chemical Composition
   V. Preparation and Properties of the Subunits
   VI. Biological Properties of Thyrotropin
   VII. Primary Structure of the Subunits
   VIII. Chemical Similarities among Human Glycoprotein Hormones
   IX. Immunological Characteristics of Thyrotropin
   X. Relationship between Pituitary Thyrotropin and Human Chorionic Thyrotropin
   XI. Concluding Remarks
   References
2. Thyroid Hormones and Analogs. I. Synthesis, Physical Properties and Theoretical Calculations
   I. Introduction
   II. Methods of Synthesis
   III. Physical Properties
   IV. Theoretical Calculations
   References
3. Thyroid Hormones and Analogs. II. Structure-Activity Relationships
   I. Introduction
   II. Biological Test Systems
   III. Structure-Activity Relationships
   IV. General Summary and Comments
   References
4. The Mechanism of Thyroxine Action
   I. Overview
   II. Role of Iodocompounds
   III. General Aspects of Iodothyronine Action
   IV. Requirements of a Comprehensive Hypothesis of Thyroid Hormone Action
   V. Mechanisms of Thyroid Hormone Action: Current Hypotheses
   VI. Concluding Statement
   References
5. Cellular and Molecular Aspects of Thyroid Hormone Action during Amphibian Metamorphosis
   I. Introduction
   II. Thyroid Hormones
   III. Amphibian Metamorphosis
   IV. Metabolic Regulation and Calorigenesis
   V. Primary Events and Mechanism of Thyroxine Action
   VI. Summary
   VII. Addendum
   References
6. Evolution of Thyroid Function
   I. Introduction
   II. Iodoproteins in Invertebrates
   III. Prevertebrates and Primitive Vertebrates
   IV. Thyroid Gland Secretions
   References
7. The Thyroid Hormones: Historical Aspects
   I. Introduction
   II. The Colloid of the Thyroid
   III. Thyroxine: E.C. Kendall
   IV. Thyroxine: C.R. Harington
   V. Configurative Relationship between Throxine and Tyrosine
   VI. Glaxo Synthesis of L-Thyroxine
   VII. Isolation of Diiodotyrosine from the Thyroid Gland
   VIII. The Circulating Thyroid Hormone
   IX. Thyroxine and Total Thyroidal Activity
   X. Radioactive Iodine in Thyroid Research
   XI. Triiodothyronine
   XII. Other Iodothyronines
   References
   Author Index
   Subject Index