The Sugar Code

Ein neues Lehrbuch der Glykobiologie, das einen umfassenden Einblick in die Biochemie und die biologische und medizinische Relevanz von glykosylierten Biomolekülen gibt. Zusammengestellt von einem führenden Pionier auf dem Gebiet gemeinsam mit einem internationalen Expertenteam.

Auteur
Hans-Joachim Gabius obtained his Ph.D. in 1982 at the Max-Planck-Institute for Experimental Medicine in Gottingen. After doing post-doctoral research from 1984-1985 in the group of S. H. Barondes at the UC San Diego, he was appointed first as assistant professor for biochemistry at the Max-Planck-Institute for Experimental Medicine in Gottingen (1987) and then as associate professor for pharmaceutical chemistry at the University of Marburg (1991). Since 1993 he is heading the Institute for Physiological Chemistry, Faculty of Veterinary Medicine at the University of Munich. Prof. Gabius received numerous research awards including the Otto-Hahn-Medal (1983), the Award of the Dr. Carl-Duisberg-Foundation (1988) and the Award of the Paul-Martini-Foundation (1990). His research interests are focused on chemical, biophysical and biochemical analysis of protein - carbohydrate interactions with biomedical relevance, such as the development of glycoscientific strategies for tumor diagnosis and therapy and the elucidation of functions of mammalian lectins. His research led to a prominent placement in the ISI ranking of highly cited papers in 1998.

Texte du rabat
A reader friendly, strategically structured introduction to glycosciences, guiding from the basics of the sugar alphabet and pertinent aspects of chemical/natural glycosylation to functional carbohydrate recognition (sugar code), with an eye on emerging medical relevance. All chapters, intimately connected by cross-referencing, share the same interdisciplinary level to make the information readily digestible. Story-telling info boxes add an entertaining touch. Written by a team of renowned glycoscientists from the forefront of research with the clear intention to convey their enthusiasm for teaching key lessons and edited by a leading figure of the field, this book is a perfect primer for students in life and medical sciences and for specialists looking for a concise overview. With its remarkable set of summary illustrations and its focus on landmark references, it is ideally suited as practical resource to teach classes, run courses and get prepared for contributing to the dynamic development of glycosciences.

Supplementary Material is available at www.wiley-vch.de/home/thesugarcode

Résumé
A reader friendly overview of the structure and functional relevance of natural glycosylation and its cognate proteins (lectins), this book is also one of the few books to cover their role in health and disease. Edited by one of the pioneering experts in the field and written by a team of renowned researchers this resource is a perfect introduction for all students in life and medical sciences, biochemistry, chemistry and pharmacy.
Website: WWW.WILEY-VCH.DE/HOME/THESUGARCODE

Contenu
CHEMICAL BASIS
The Biochemical Basis and Coding Capacity of the Sugar Code (Rudiger, Gabius)
Three-dimensional Aspects of the Sugar Code (Kozar, Andre, Ulicny, Gabius)
The Chemist's Way to Synthesize Glycosides (Oscarson)
The Chemist's Way to Prepare Multivalency (Chabre, Roy)
Analytical Aspects: The Analysis of Protein-Bound Glycans (Nakagawa)
NATURAL GLYCOSYLATION -
GLYCOPROTEINS
N-Glycosylation (Zuber, Roth)
O-Glycosylation: Structural Diversity and Functions (Patsos, Corfield)
Glycosylation of Model and "Lower" Organisms (Wilson, Paschinger, Rendic)
Glycosylphosphatidylinositol Anchors: Structure, Biosynthesis and Functions (Shams-Eldin, Debierre-Grockiego, Schwarz)
NATURAL GLYCOSYLATION -
GLYCOLIPIDS, PROTEOGLYCANS, CHITIN
Glycolipids (Kopitz)
Proteoglycans (Buddecke)
Chitin (Merzendorfer)
PROTEIN-CARBOHYDRATE INTERACTIONS
Protein-Carbohydrate Interactions: Basic Concepts and Methods for Analysis (Solis, Romero, Menendez, Jimenez-Barbero)
How to Determine Specificity: From Lectin Profiling to Glycan Mapping and Arrays (Tateno, Kuno, Hirabayashi)
The History of Lectinology (Rudiger, Gabius)
Ca2+: Mastermind and Active Player for Lectin Activity (Including a Gallery of Lectin Folds) (Gabius)
Bacterial and Viral Lectins (Holgersson, Gustafsson, Gaunitz)
Plant Lectins (Rudiger, Gabius)
Animal and Human Lectins (Gabius)
Routes in Lectin Evolution: Case Study on the C-Type Lectin-Like Domains (Gready, Zelensky)
Carbohydrate-Carbohydrate Interactions (Bucior, Burger, Fernandez-Busquets)
BIOMEDICAL ASPECTS AND CASE STUDIES
Diseases of Glycosylation (Hennet)
Animal Models to Delineate Glycan Functionality (Honke, Taniguchi)
Glycobiology of Fertilization and Early Embryonic Development (Habermann, Sinowatz)
Glycans as Functional Markers in Malignancy? (Andre, Kopitz, Kaltner, Villalobo, Gabius)
Small is Beautiful: Mini-Lectins in Host Defense (Lehrer)
Inflammation and Glycosciences (Schwartz-Albiez)
Sugars as Pharmaceuticals (Osborn, Turkson)
Platelet Glycoproteins as Lectins in Hematology (Hoffmeister, Falet)
Neurobiology meets Glycosciences (Ledeen, Wu)

COMPANION WEB-SITE: www.wiley-vch.de/home/thesugarcode