The Role of Products of the Histocompatibility Gene Complex in Immune Responses

The Role of Products of the Histocompatibility Gene Complex in Immune Responses documents the proceedings of a conference held on 3-7 November 1975, which brought together an international group of scientists spanning three independent disciplines-genetics and immunogenetics, molecular biochemistry, and immunobiology-with clinical medicine overlapping these disciplines.
This volume contains 42 papers organized according to the eight sessions held at the conference. The papers in Session I examined the genetics of the major histocompatibility complex. Session II presented studies on the biology of mixed lymphocyte interactions and cell-mediated cytotoxicity reactions. Session III discussed immune response gene systems while Session IV dealt with the genetic control of cell interactions. The papers in Session V covered idiotypic determinants on T cell receptors. Session VI investigated the properties of histocompatibility gene products involved in regulation of immune responses. Session VII focused on the biochemistry and immunocytology of cell surface products of the major histocompatibility complex. Finally, Session VIII discussed interrelationships between products of the major histocompatibility complex and their relevance to disease.

Contenu

Participants
Preface
Photographs of Participants
Session 1: Genetics of the Major Histocompatibility Complex
Genetic Resolution of the Products and Functions of I and S Region Genes of the Mouse H-2 Complex
Discussion following Donald Shreffler
The Genetics of the Major Histocompatibility Complex in Man, HLA
Discussion following Jon van Rood
Molecular Relationships of Ia Antigens Controlled by the Same and by Different Subregions of the I Region
Br and Wh, B Cell Antigens in Gluten Sensitive Enteropathy and Dermatitis Herpetiformis
Recent Studies of Ia like Antigens and Complement Components Relating to the Human Histocompatibility System
Natural Killer Cells in the Mouse
Evidence for the Association of Specificity Ia. 3 with an I-A Region Molecule
General Discussion - Session
Session II: The Biology of Mixed Lymphocyte Interactions and Cell-Mediated Cytotoxicity Reactions
Genetic and Cellular Aspects of Mixed Leukocyte Culture and Cell Mediated Lympholysis Reactions
Discussion following Fritz Bach
Bifunctional Histocompatibility-Linked Regulation of Cell Mediated Lympholysis to Modified Autologous Cell Surface Components
Discussion following Gene Shearer
The Role of Ia Antigens in MLC Stimulation
H-2 Associated MLR Determinants: Immunogenetics of the Loci and Their Products
Responses of Alloantigen Reactive Lymphocytes to Conventional Antigens
Evidence for Several Closely Linked Genes Involved in Generation of Proliferation in MLC
Suppressive Interactions between Different MLR Loci
Does the Apparent H-2 Compatibility Requirement for Virus-Specific T Cell-Mediated Cytolysis Reflect T Cell Specificity for "Altered Self" or Physiological Interaction Mechanisms?
General Discussion - Session
Session III: Immune Response (Ir) Gene Systems
The Nature and Function of Specific H-Linked Immune Response Genes and Immune Suppression Genes
Discussion following Baruj Benacerraf
Functional Analysis of Ia Antigens in Relation to Genetic Control of the Immune Response
Discussion following Hugh McDevitt
H-2 Linked Immune Response Genes: Multiplicity and Functional Complementation
H-3-Linked Unresponsiveness to EA-1 and H-13 Antigens
Immune Responses of Mice against Modified Random Polymers of Amino Acids, and Implications in Gene Control
A Possible Function for Products of the Major Histocompatibility Complex in Humoral Immunity
General Discussion - Session
Session IV: Genetic Control of Cell Interactions
Macrophage-T Lymphocyte Interaction: The Cellular Basis for Genetic Control of Antigen Recognition
Discussion following Alan Rosenthal
Genetic Control of Lymphocyte Interactions and Differentiation
Discussion following David Katz
Stimulation of Antibody Responses In Vitro by Antigen-Bearing Syngeneic and Allogeneic Macrophages
H-2 Linked Ir Gene Regulation of Delayed-Type Hypersensitivity in Mice
Differential Expression of Ia Antigens on Suppressor T Cells, Helper T Cells, and B Precursor Cells
Effective Allogeneic T Cell-B Cell Interaction in Chimeric Mice
General Discussion - Session
Session V: Idiotypic Determinants on T Cell Receptors
T Lymphocyte Receptor Analysis by Anti-Idiotypic Stimulation
Discussion following Klaus Rajewsky
Idiotypic Receptors for Antigen on T Lymphocytes
Discussion following Hans Wigzell
Session VI: Properties of Histocompatibility Gene Products Involved in Regulation of Immune Responses
The Nature of Antigen Specific T Cell Factors Involved in the Genetic Regulation of Immune Responses
Discussion following Edna Mozes
Characterization of the Antigen-Specific Suppressive T Cell Factor with Special Reference to the Expression of I Region Genes
Discussion following Tomio Tada
Histocompatibility Gene Products as Mediators of Lymphocyte Interactions
I-Region Gene Products in Cell Cooperation
Suppressive Activity of Lymphoid Cell Extracts from Non-Responder Mice Injected with the Terpolymer L-Glutamic Acid60-L-Alanine30-L-Tyrosine10 (GAT)
Anti-ß2 Microglobulin - a Selective PBA for Human and Mouse B Lymphocytes
General Discussion - Session
Session VII: Biochemistry and Immunocytology of Cell Surface Products of the Major Histocompatibility Complex
Cytological Analysis of Histocompatibility Molecules
Discussion following Emil Unanue
Isolation and Structure of Products of the Human Histocompatibility Gene Complex
Discussion following Jack Strominger
Studies on the Chemical Basis of Variability and the Complex Cellular Expression of the H-2K and H-2D Products
Discussion following Stanley Nathenson
Structure and Biological Activity of H-2 Antigens
Genetic and Evolutionary Implications of the Partial Amino Acid Sequences of H-2K and H-2D Alloantigens
The Chemistry of Mouse and Guinea Pig Ia Antigens
General Discussion - Session
Session VIII: Interrelationships between Products of the Major Histocompatibility Complex and Their Relevance to Disease
General Discussion
1a) Specificity of H-Linked Ir Gene Function
1b) Microheterogeneity of Ia Molecules
2) Evidence for Existence of a Distinct 1-B Sub-Region
3a, b, c) Nature of the Antigen Receptor on T Cell Factors and Relationship to vH Regions and Ig Idiotypes; Their Specificity Range as Compared to Immunoglobulins; and Possible Existence of Dual Recognition Systems at the T Cell Level and at Other Levels
4) Similarities and Differences between Helper and Suppressor Factors
5) Basis for the Large Numbers of Allospecific T Cells Recognizing MHC Antigens
6) The Phenomenon of Cis-Trans Preference in Complementation of Ir Genes and Its Relevance to Linkage Disequilibrium in MHC
7) The Basis for Presence or Absence of Genetic Restrictions in T-B Cell Cooperation - Adaptation or Selection?
Relationship of the MHC to Disease