The Retina A Model for Cell Biology Studies Part_2

The Retina: A Model for Cell Biology Studies, Part II, is the second of a two-part series that details developments in the study of retinal cell biology.
The book begins with a review of the current evidence for the role of putative neurotransmitters at particular synapses in the retina. It then discusses pre- and postsynaptic regulatory mechanisms; the interactions of neurotransmitter-neuromodulatory systems; and cellular effects of putative neurotransmitters and neuromodulators. This is followed by an introduction to vision psychophysics, showing its application in studying the functioning of cells in the retina.
The remaining chapters discuss how the retinal pigment epithelium cell might be used as a model for studying biological problems of current interest; extracellular matrix molecules; concepts and controversies regarding the biology of endothelial cells, the key elements in the phenomenon of intraocular neovascularization; the use of genetic mutations and genetic mosaics for the study of the retina; and the retina as a regenerating organ.

Contenu

Contributors
Preface
Neurotransmitters and Neuromodulators in the Retina: Regulation, Interactions, and Cellular Effects
I. Introduction
II. Putative Neurotransmitters and Neuromodulators of Retinal Neurons
III. Pre- and Postsynaptic Regulatory Mechanisms
IV. Interactions of Neurotransmitters and Neuromodulators
V. Cellular and Morphological Effects of Neurotransmitters and Neuromodulators
VI. Concluding Remarks
References
Vision Psychophysics and Retinal Cell Biology
I. Introduction
II. The Systems Approach of Psychophysics
III. Psychophysical Studies of Photoreceptor Physiology
IV. Psychophysical Studies of Abnormal Retinal Physiology in Retinitis Pigmentosa
V. Retinal Cell Biology from a Psychophysicist's Perspective
References
The Cell Biology of the Retinal Pigment Epithelium
I. Summary of RPE Cell Structure and Functions
II. Cellular Processes That Have Been Studied in the RPE
III. Use of Cultured RPE Cells to Study Cellular Processes
IV. Summary and Future Research
References
Extracellular Matrix Molecules: Their Importance in the Structure and Function of the Retina
I. Introduction
II. Extracellular Matrices
III. Retinal Extracellular Matrices
IV. Effects of Extracellular Matrix Molecules on Retinal Neurons
V. Concluding Comments
References
Cell Biology and Biochemistry of Endothelial Cells and the Phenomenon of Intraocular Neovascularization
I. Introduction
II. New Vessels from Preexisting Vessels
III. Steps in Capillary Formation
IV. Maturation of the Vascular Bed
V. Factors Influencing Capillary Sprout Formation
VI. Conclusion
References
Genetic Mosaics as Tolls for the Study of the Retina
I. A Modest Catalog of Known Mutations Affecting the Eye
II. Genetic Mosaics: A Primer
III. The Study of the Site of Gene Action
IV. The Study of Cell Lineage
V. The Study of Embryonic Retinal Development
VI. General Conclusions
References
The Retina as a Regenerating Organ
I. Introduction
II. Characteristics of Regenerating Goldfish Retinal Ganglion Cells
III. Conditions That Modify Axonal Outgrowth
IV. Regulation of the Cell Body Reaction
V. General Conclusions
References
Index