The Plasma Proteins V2

The Plasma Proteins, Volume II: Biosynthesis, Metabolism, Alternations in Disease is a 10-chapter text that explores the physiological role and metabolic interrelationships of the human plasma proteins in the normal state and in disease.
The first two chapters cover the physical properties, chemical composition, function, methods of analysis of human serum lipoproteins and plasma enzymes. The subsequent chapter considers the normal levels of hormones in plasma or serum and their distribution in the plasma protein fractions. These topics are followed by discussions on the blood coagulation system, the serum proteins in the animal kingdom at maturity and during embryonic development, and the biosynthesis of plasma proteins. The remaining chapters examine the qualitative abnormalities in various plasma proteins. These chapters also discuss the modification in plasma protein synthesis induced by genetic variation. Such alterations are described for albumin, ceruloplasmin, haptoglobin, iron-binding globulin, fibrinogen, antihemophilic globulin, and other blood clotting factors, as well as -globulin.
Biochemists, physiologists, and medical researchers will find this book invaluable.

Contenu

Contributors to Volume II

Contributors to Volume I

Preface

List of Tables in Volume II

Contents of Volume I

11. Structure and Function of Human Serum Lipoproteins

    I. Introduction

    II. Ultracentrifugal Lipoprotein Flotation Methodology

    III. Interrelationships between Lipoprotein Measurements

    IV. Physical Properties of the Serum Lipoproteins

    V. Chemical Composition of the Serum Lipoproteins

    VI. Lipoprotein Structure

    VII. Lipoprotein Distributions in Human Populations

    VIII. Serum Lipoproteins in Various Metabolic States

    IX. Serum Lipoproteins in Evaluation of Subclinical Metabolic Status

    X. Factors Influencing Lipoprotein Concentrations In Vivo

    XI. Metabolic Data on Plasma Lipoproteins

    References

12. Plasma Enzymes

    I. Introduction

    II. Identity of Plasma Enzymes

    III. Properties and Individuality of the Role of Certain Plasma Enzymes

    IV. Measurement of Enzymes in Plasma

    V. Identification of Tissue Origin

    VI. Origin of Plasma Enzymes

    VII. Fate of Plasma Enzymes

    VIII. Homeostasis of Plasma Enzymes

    References

13. Circulating Hormones

    I. Introduction

    II. Hormone Levels in Human Plasma

    III. Hormones of the Pituitary Gland

    IV. Insulin

    V. Thyroid Hormones

    VI. Steroid Hormones

    VII. Epinephrine and Norepinephrine

    VIII. Erythropoietin

    IX. General Discussion

    References

14. The Blood Coagulation System

    I. Introduction

    II. Fibrin and Fibrin Formation

    III. Fibrinogen, Thrombin, and Their Interaction

    IV. Prothrombin and Its Activation

    V. Blood Thromboplastin

    VI. Physiological Blood Coagulation

    VII. The Measurement of Clotting Efficiency

    VIII. Physiological and Pathological Variations in the Clotting Mechanism

    References

15. Comparative Biochemistry and Embryology

    I. Introduction

    II. Methods

    III. Plasma Protein Composition Throughout the Animal Kingdom

    IV. Physiological Relationships

    V. Genetic, Taxonomical, and Phylogenetic Relationships

    VI. Embryonic Development

    VII. Cellular Sites of Synthesis

    VIII. Summary and Conclusions

    References

16. The Biosynthesis of Plasma Proteins

    I. Introduction

    II. General Considerations on Protein Metabolism

    III. General Considerations on Protein Turnover

    IV. General Considerations of y-Globulin Formation

    V. Plasma Protein Metabolism

    VI. -Globulin Biosynthesis

    VII. Summary

    References

17. Alterations in Plasma Protein Patterns in Disease

    I. Introduction

    II. Methods

    III. Pre-Albumins

    IV. Albumin

    V. a-Globulins

    VI. ß-Globulins

    VII. The C-Reactive Protein

    VIII. Properdin

    IX. Fibrinogen

    X. -Globulin

    XI. Summary and Conclusions

    References

18. Abnormal Serum Globulins

    I. Introduction

    II. Identification of Pathological Globulins in Sera

    III. Physical Characterization and Homogeneity of Purified Abnormal Globulins

    IV. Chemical Composition and Structure

    V. Antigenic Constitution and Immunological Relationships

    VI. Physical and Chemical Differentiation of Abnormal Serum Globulins and Bence-Jones Proteins

    VII. Transmissible Mouse Plasmocytomas

    VIII. Biosynthesis of Abnormal Proteins

    IX. Conclusion and Summary

    References

19. Genetic Alterations in Plasma Proteins of Man

    I. Introduction

    II. Albumins

    III. Ceruloplasmin

    IV. Haptoglobins

    V. Iron-Binding Globulins or Transferrins

    VI. Blood Coagulation Factors

    VII. -Globulins

    VIII. Miscellaneous Hereditary Diseases

    IX. Growth and Development

    X. Epilogue

    References

Author Index

Subject Index