The Nucleic Acids

The Nucleic Acids, Volume III covers the significant progress in understanding the chemistry and biological importance of the nucleic acids.
This volume is composed of 12 chapters, and begins with an overview of the general principles of the determination of weight, shape, and dimension of large molecules in solution. These topics are followed by discussions on the photochemistry of nucleic acids and its constituents; chemical and enzymic synthesis of polynucleotides; and nucleic acid content and dynamics of bacterial viruses. The next chapters describe the biosynthesis of purine and pyrimidine nucleotides. A chapter examines the relationship of nucleic acid and protein synthesis through considering cell-free systems, particularly those derived from mammalian tissues. Another chapter looks into the protein biosynthesis in intact bacterial cells. The final chapters explore the nucleic acid metabolism, with a special emphasis on the effect of radiation on the process.
This book is of value to organic chemists and biochemists.

Contenu

Contributors to Volume III
Preface
Contents of Volume I and Volume II
Errata, Volume I and Volume II

29. Deoxyribonucleic Acids as Macromolecules
    I. Introduction
    II. A Brief Survey of the General Principles of the Determination of Weight,Shape,and Dimensions of Large Molecules in Solution
    III. DNA Particles in Dilute Solutions
    IV. Conclusions
30. Photochemistry of Nucleic Acids and Their Constituents
    I. Introduction
    II. Principles of Photochemistry
    III. Photochemical Techniques
    IV. Optical Properties and Techniques
    V. Photochemistry of Nucleic Acid Constituents
    VI. Photochemistry of Nucleic Acids
    VII. Reversibility of Nucleic Acid Photolysis
    VIII. Radiation Receptors in Living Organisms
    IX. Viruses
    X. Photoreactivation
    XI. Addendum
    XII. General Bibliography
31. Chemical and Enzymic Synthesis of Polynucleotides
    I. Abbreviated Formulations and Nomenclature of Polynucleotides
    II. Chemical Synthesis of Polynucleotides
    III. Enzymic Synthesis of Ribopolynucleotides
    IV. Enzymic Synthesis of Deoxyribopolynucleotides
32. Chemistry of the Nucleic Acids of Microorganisms
    I. Introduction
    II. Nucleic Acid Content and Dynamics
    III. Constituents of Nucleic Acids
    IV. Nucleic Acid Composition and Specificity
33. The Nucleic Acids of the Bacterial Viruses
    I. Introduction
    II. Nucleic Acids of the T-Even Phages
    III. Nucleic Acids of Other T Bacteriophages
    IV. Nucleic Acids of Temperate Bacteriophages
    V. Nucleic Acids of Minute Bacteriophages
    VI. Conclusion
34. The Ribonucleic Acids of Viruses
    I. Introduction
    II. Viruses Which Contain Ribonucleic Acid; General Remarks
    III. The Ribonucleic Acids of Plant Viruses
    IV. The Ribonucleic Acids of Animal Viruses
35. Biosynthesis of Purine Nucleotides
    I. Introduction
    II. Precursors of the Purines
    III. Enzymic Reactions of Inosinic Acid Synthesis de Novo
    IV. Enzymic Synthesis of Formyltetrahydrofolic Acid Compounds
    V. Synthesis of Adenylic Acid from Inosinic Acid
    VI. Synthesis of Guanylic Acid from Inosinic Acid
    VII. Summary
36. Biosynthesis of Pyrimidine Nucleotides
    I. Introduction
    II. Biosynthesis of Uridine Nucleotides
    III. Biosynthesis of Cytidine and Deoxycytidine Nucleotides
    IV. Biosynthesis of Thymidine Nucleotides
    V. Alternative Pathways of Pyrimidine Nucleotide Synthesis
37. The Relationship of Nucleic Acid and Protein Synthesis as Revealed Studies in Cell-Free Systems
    I. Introduction
    II. Participation of Cellular Nucleic Acid-Containing Fractions in Protein Synthesis
    III. Theoretical Considerations
38. Biosynthesis of Proteins in Intact Bacterial Cells
    I. Introduction
    II. Organization of the Bacterial Cell
    III. Synthesis of Macromolecular Components during Normal Bacterial Growth
    IV. Uncoupled Synthesis of Macromolecules in Bacteria
    V. Protein Synthesis After Selective Destruction or Removal of a Nucleic Acid
    VI. General Discussion
    VII. Addendum
39. Agents Which Influence Nucleic Acid Metabolism
    I. Introduction
    II. Compounds Which Interfere with the Formation of Folic Acid-Derived Coenzymes
    III. Compounds Which Interfere with Amination Reactions in Purine and Pyrimidine Synthesis
    IV. Structural Analogs of Purines and Their Metabolic Activity
    V. Structural Analogs of Pyrimidines and Their Effects on Nucleic Acid Metabolism
    VI. Other Agents Which Influence Nucleic Acid Metabolism
    VII. Concluding Remarks
40. The Effect of Radiations on Nucleic Acid Metabolism
    I. Introduction
    II. Factors Influencing Deoxyribonucleic Acid Specific Activity
    III. Radiation Effects Within One Interphase
    IV. The Analysis of the Mechanism of Radiation Effect on DNA Synthesis
    V. General Conclusions
    Author Index
    Subject Index