The Node of Ranvier

The Node of Ranvier is a collection of studies about the function, morphology, and development of the node of Ranvier from experts of different disciplines.
The book covers topics such as the evolution of the structure and structure and function of the nodes of Ranvier; membrane specialization at the nodes of Ranvier; and catch-binding. Also included in the book are studies about the structural and functional relationships of ion conduction in the myelinated and demyelinated axon; functional organization of potassium channels in axons; the effects of pathological conditions and toxins on nodes of Ranvier; and nodelike membranes at extranodal sites.
Physiologists, biochemists, pharmacologists, cell biologists, neurologists, and neuropathologists who would like to find out more and make a study about the node of Ranvier will find the text helpful and relevant.

Contenu

Contents
Contributors
Preface
Evolutional Aspects of the Structure and Function of the Nodes of Ranvier
I. Introduction
II. Morphology
III. Functional Parameters
IV. Electrophysiological Considerations
V. Conclusions
References
Membrane Specialization at the Nodes of Ranvier and Paranodal and Juxtaparanodal Regions of Myelinated Central and Peripheral Nerve Fibers
I. Introduction
II. The Node of Ranvier
III. The Paranodal Region
IV. The Juxtaparanodal Internode
V. Developmental Studies
VI. Possible Mechanisms of Nodal Differentiation
VII. Effects of Demyelinating Agents
VIII. Aberrant Nodal and Paranodal Structures
References
Cation Binding at the Node of Ranvier
I. Introduction
II. Localization of Cation-Binding Reaction Product in the Normal, Myelinated Axon
III. Localization of Binding during Development
IV. Cation Binding under Pathological Conditions
V. Cation Binding in Saltatory Conduction
VI. Conclusions
References
Formation and Morphology of the Nodes of Ranvier in Cultures of CNS and PNS
I. Introduction
II. Nodes of Ranvier
III. Neurotoxic Effects
IV. Conclusion
References
Structural and Functional Relationships of Ion Conduction in the Myelinated and Demyelinated Axon
I. Introduction
II. Historical Development of the Description of Saltatory Conduction
III. Modern Study of the Molecular Architecture of Myelinated Nerve Membrane
IV. Pathophysiology of Conduction in Demyelinated Nerve Fibers
V. Conclusions
References
Structure and Function of the Cytoskeleton
and Endomembrane Systems at the Node of Ranvier
I. Introduction
II. General Organization of Eucaryotic Cytoplasm
III. Components of the Axonal Cytoskeleton and Cytomusculature
IV. Endomembrane and Cisternal Systems of the Node and Paranode
V. Connections between the Cytoskeleton and the Endomembrane Systems
VI. Paranodal and Nodal Membrane Specializations as Shown by Freeze-Fracture
VII. Conclusions
References
Functional Oganization of Potassium Channels in Normal and Pathological Mammalian Axons
I. Introduction
II. Firing Characteristics and Accommodation of Normal and Pathological Axons
III. Potassium Channels and Stabilization of Nodal Firing Properties during Axon Maturation
IV. Role of Potassium Conductance in Activity-Dependent Excitability Changes
V. Electrical Field Effect Interactions in Normal and Pathological Nerve Bundles
VI. Potassium Channel Organization in Pathological Axons
VII. Localization of Potassium Channels during Development and Regeneration
VIII. Concluding Remarks
References
Nodes of Ranvier in Pathological Conditions
I. Introduction
II. The Normal Nodes
III. Pathology of the Node
References
Toxic Effects on the Node of Ranvier
I. Effects of Neurotoxic Substances upon Axons
II. Effects of Neurotoxic Substances upon Schwann Cells and the Myelin Sheath
References
Normal and Defective Differentiation of the Nodes of Ranvier in Neurological Mutants of the Mouse
I. Introduction
II. Morphological, Physiological, and Biochemical Aspects of Nodes of Ranvier in Normal, Developing, and De- or Re myelinating Peripheral Nerves
III. Cell Interactions at the Nodes of Ranvier in Peripheral Nerves of the Neurological Mutants of the Mouse during Development and Adulthood
IV. Conclusion
References
Nodelike Membrane at Extranodal Sites: Comparative Morphology and Physiology
I. Introduction
II. Differentiation of Nodal Membrane
III. Differentiation of Nodelike Membrane in the Absence of Myelin: Developing Axons
IV. Foci of Nodelike Membrane in Specialized Nonmyelinated Fibers
V. The Initial Segment: Specialized Membrane Properties at the Encoding/Trigger Zone
VI. Heminodes and the Invasion of Preterminal Fibers
VII. Conclusions
References
Sprouting and Regeneration of Peripheral Nerve
I. Introduction
II. Distal and Proximal Consequences of Neural Trauma
III. Neuronal Regeneration
IV. The Growth Cone and the Environment
V. Neurite Dynamics during Synapse Formation and Repression
VI. Sprouting
VII. Conclusions
References
Index