The Leukemias: Etiology, Pathophysiology, and Treatment

The Leukemias: Etiology, Pathophysiology, and Treatment documents the proceedings of an International Symposium on The Leukemias: Etiology and Pathophysiology, held at Henry Ford Hospital, Detroit, Michigan, 8-10 March 1956. This volume gives the present complex position of leukemic etiology and pathophysiologic disturbance, a much needed knowledge of detailed leukocytic functions and comprehensive thought on the therapy of the leukemias. It also establishes a basis of comparison with the earlier works of Downey and Forkner in this field in the late thirties and thus makes it possible to see with some clarity the extent of progress made.
The volume contains 39 papers organized into nine parts. The papers in Part I focus on the leukemic cell, its structure, and antigenicity. Part II presents studies on genetic and environmental factors in the transmission of leukemia. Part III examines the radiation biology of leukocytes. Part IV focuses on the leukemias and the malignant lymphomas while Part V deals with leukocytic physiology. Part VI covers the metabolism of amino and nucleic acids in the leukemias. Part VII takes up further biochemical considerations in the leukemias. Part VIII contains papers that examine nucleic acids as the target for chemotherapy. Part IX presents a round-table discussion on therapy.

Contenu

Preface
Part I: The Leulcemic Cell, Its Structure and Antigenicity

1. Electron Microscopy of Normal and Leulcemic Leukocytes
   Added Comment
2. Phase-Contrast Microscopy of Leukocytes
   Added Comment
   General Discussion
3. Antigenicity of Leukocyte Fractions
4. Some Studies on Leukocyte Agglutinins
   Added Comment
   General Discussion
   Part II: Genetic and Environmental Factors in the Transmission of Leukemia
5. The Pathophysiology and Immunogenetics of Transplantable Leukemia
6. Genetic and Nongenetic Factors Influencing the Induction of Mouse Leukemia
7. Viral Etiology of Mouse Leukemia
   Added Comment
   General Discussion
8. Environmental Factors in Human Leukemia
   Part III: Radiation Biology of Leukocytes
9. Radiation Injury and Regeneration in Lymphoid Tissues
10. Cytocidal Action of X-Rays on Lymphocytes According to Time-Lapse Cinemicrography and Unstained Cell Counts
    Added Comment
    Added Comment
    General Discussion
    Part IV: The Leukemias and the Malignant Lymphomas
11. The Leukemias-Their Scope
12. The Malignant Lymphomas
    Part V: Leukocytic Physiology
13. Cultivation of Leukemic Cells in the Cartesian Diver
14. Observations on Human Leukemic Cells in Culture
15. Newer Concepts of Leukopoiesis as Revealed by Leukopheretic and Isotopic Techniques
16. Endocrine Influences on Blood Formation
    Added Comment
    General Discussion
17. The Influence of Cellular Fractions of Whole Blood on the Course of Acute Lymphocytic Leukemia: A Preliminary Report
18. The Leukocytic Resistance Test
    General Discussion
    Part VI: Metabolism of Amino and Nucleic Acids in the Leukemias
19. Some Aspects of Amino Acid Metabolism in Leukemia
20. Urinary Amino Acid Excretion in Leukemia
21. Free or Easily Extractable Amino Acids in Blood Cells and Body Fluids
    General Discussion
22. Metabolic Stability of PNA and DNA in Human Leukemic Leukocytes; The Function of Lymphocytes
23. Urinary Uric Acid Excretion in Leukemia
24. Nucleic Acids, Nucleases, and Nuclease Inhibitors in Leukemia
25. Studies on Cysteine Metabolism in Leukemia
    General Discussion
    Part VII: Further Biochemical Considerations in the Leukemias
26. Immunologic Studies of Protein Synthesis in Leukemia
27. Biochemical and Enzymatic Characteristics of Normal and Leukemic Leukocytes (with Particular Reference to Leukocyte Alkaline Phosphatase)
28. Metabolism of Folic Acid and Citrovorum Factor in Leukemic Cells
    Added Comment: Labeling of RNA of Rabbit Peritoneal Exudate Polymorphonuclear Leukocytes
    General Discussion
29. Lactic Acid Production by Polymorphonuclear Leukocytes
30. Diagnostic and Nosological Problems at the Borderline of Leukemia
    General Discussion
    Part VIII: Nucleic Acids as the Target for Chemotherapy: Mechanisms of Drug Action and Resistance
31. Nucleic Acids and Related Derivatives as Targets for Chemotherapy
32. Uracil Antagonists As Inhibitors of Transplantable Tumors
33. The Specific Action of Azaserine on Enzymes Concerned with Purine Biosynthesis
34. Nucleotide Metabolism and Cancer Chemotherapy
    General Discussion
35. Purine Nucleotide Biosynthesis and Neoplasia
36. Anticancer Agents and Nucleic Acid Metabolism of Isolated Human Leukocytes
37. Studies on Resistance to Folic Acid Antagonists
38. Metabolic and Nutritional Variations in Drug-Resistant Streptococcus Faecalis
    General Discussion
39. Round-Table Discussion on Therapy
    Author Index
    Subject Index