The Glycoconjugates V2

The Glycoconjugates: Mammalian Glycoproteins, Glycolipids, and Proteoglycans Volume II is a collaboration of different experts in the field of molecular biology on the subject of glycoconjugates.

The text of the second volume covers topics such as the structure and biosynthesis of connective tissue proteoglycans, glycoproteins, and glycolipids; and glycoprotein and glycolipid catabolism and degradation. It also discusses the structure, composition, and isolation of surface membranes; and lectins - its immunological aspects and its use in the study of mammalian glycoprotein.

The book is recommended for molecular biologists, organic chemists, and biochemists who would like to know more about glycolipids and glycoproteins and their applications.

Contenu

List of Contributors

Preface

Contents of Volume I

1 Proteoglycans and Structural Glycoproteins

Section 1 Structure and Biosynthesis of Connective Tissue Proteoglycans

I. Introduction

II. Hyaluronic Acid

III. Chondroitin Sulfate Proteoglycans

IV. Heparin

V. Acidic Glycosaminoglycans and the Cell Nucleus

References

Section 2 Connective Tissue Glycoproteins

Text

References

Section 3 The Carbohydrate of Collagen

I. Introduction

II. Structure and Linkage of Hexose

III. Occurrence in the Different Collagen Types

IV. Biosynthesis of Hydroxylysine and the Attachment of Carbohydrate

References

2 Glycoprotein Biosynthesis

I. Introduction

II. Biosynthesis of Monosaccharides and Their Activated Derivatives

III. Biosynthesis of Asn-GlcNAc-Type Oligosaccharides of Secretory Glycoproteins

IV. Biosynthesis of Ser(Thr)-GalNAc-Type Oligosaccharides of Secretory Glycoproteins

V. Biosynthesis of Membrane-Bound Glycoproteins

VI. The Control of Glycoprotein Biosynthesis

References

3 Glycoprotein Catabolism

Section 1 Degradation of Glycoproteins

I. Introduction

II. Role of Lysosomes

III. Specific Enzymes Involved in Degradation of Glycoproteins

IV. Proteolytic Enzymes of Lysosomes

V. Estimates of Degradation and Daily Turnover

VI. Disorders of Glycoprotein Catabolism

References

Section 2 Signals for Degradation of Glycoproteins

Text

References

Section 3 Degradation of Mucus Glycoproteins in the Gastrointestinal Tract

I. Introduction

II. Degradation of Mucus Glycoproteins by Digestive Secretions

III. Degradation of Mucus Glycoproteins by the Enteric Microflora

IV. Some Pathophysiological and Biological Implications

References

4 Glycolipid Biosynthesis

I. Introduction

II. The Biosynthesis of Ceramide

III. Synthesis of 1-O-Galactosylceramide

IV. Biosynthesis of Galactosyldiglycerides in Nervous Tissue and Their Association with Myelin

V. Biosynthesis of Sulfatide (GL-1bS)

VI. Biosynthesis of Sulfogalactolipid and Its Role in the Developmental Biology of the Testis

VII. Biosynthesis of Digalactosylceramide (GL-2b)

VIII. Biosynthesis of 1-O-Sialogylcosphingolipids (Gangliosides)

IX. Biosynthesis of Neutral Glycosphingolipids

X. Biosynthesis of Glycosphingolipids with Blood Group Activity

XI. Regulation of Glycosphingolipid Synthesis in Cultured Cells

XII. Conclusions

References

5 Glycolipid Catabolism

I. Introduction

II. The Role of Neuraminidase in Glycosphingolipid Catabolism

III. The Role of ß-Galactosidases in Glycolipid Catabolism

IV. The Role of N-Acetyl-ß-Hexosaminidase in Glycolipid Catabolism

V. The Role of ß-Glucosidase in Glycolipid Catabolism

VI. Ceramidase

VII. The Metabolic Fate of Sphingosine

VIII. Arylsulfatase A (Cerebroside Sulfate Sulfatase)

IX. a-Galactosidase

X. a-L-Fucosidase

XI. Role of Lysosomal Glycosphingolipid Hydrolases in Other Human Diseases

XII. Enzyme Replacement Therapy

XIII. Inborn Errors of Glycoprotein Catabolism

XIV. Conclusions as to the Role of Glycosphingolipid Catabolism in Mammalian Cell Metabolism

References

6 Surface Membranes

I. Introduction

II. Membrane Structure

III. Isolation of Surface Membranes

IV. Composition

V. Relationship to Biological Phenomena

VI. Comments

References

7 Immunological Aspects and Lectins

Section 1 Immunological Aspects

I. Introduction

II. Background

III. Immunochemistry and Immunogenetics of Blood Group Antigens

IV. Serological Reactions of Glycolipids

V. Immunochemistry of Sialic Acid

VI. Histocompatibility Antigens

VII. Immunology and Cancer

References

Section 2 Use of Lectins in the Study of Mammalian Glycoproteins

I. Introduction

II. Methods of Isolation

III. Carbohydrate-Binding Specificity

IV. Useful Properties of Lectins

References

Index