Textbook of in vivo Imaging in Vertebrates

This book describes the new imaging techniques being developed to
monitor physiological, cellular and subcellular function within
living animals. This exciting field of imaging science brings
together physics, chemistry, engineering, biology and medicine to
yield powerful and versatile imaging approaches. By combining
advanced non-invasive imaging technologies with new mechanisms for
visualizing biochemical events and protein and gene function,
non-invasive vertebrate imaging enables the in vivo study of
biology and offers rapid routes from basic discovery to drug
development and clinical application. Combined with the
availability of an increasing number of animal models of human
disease, and the ability to perform longitudinal studies of disease
evolution and of the long-term effects of therapeutic procedures,
this new technology offers the next generation of tools for
biomedical research.

Well illustrated, largely in colour, the book reviews the most
common and technologically advanced methods for vertebrate imaging,
presented in a clear, comprehensive format. The basic
principles are described, followed by several examples of the use
of imaging in the study of living multicellular organisms,
concentrating on small animal models of human diseases. The
book illustrates:

• The types of information that can be obtained with modern in
  vivo imaging;

• The substitution of imaging methods for more destructive
  histological techniques;

• The advantages conferred by in vivo imaging in building
  a more accurate picture of the response of tissues to stimuli over
  time while significantly reducing the number of animals required
  for such studies.

Part 1 describes current techniques in in vivo imaging,
providing specialists and laboratory scientists from all
disciplines with clear and helpful information regarding the tools
available for their specific research field. Part 2 looks in
more detail at imaging organ development and function, covering the
brain, heart, lung and others. Part 3 describes the use of
imaging to monitor various new types of therapy, following the
reaction in an individual organism over time, e.g. after gene or
cell therapy.

Most chapters are written by teams of physicists and biologists,
giving a balanced coherent description of each technique and its
potential applications.

Auteur
Vasilis Ntziachristos. Massachusetts General Hospital, USA Anne Leroy-Willig. Université Paris-Sud, France

Bertrand Tavitian. Unité d'Imagerie de l'Expression des Genes, CEA - SHFJ - INSERM ERITM, Orsay Cedex, France

Texte du rabat
Textbook of in vivo Imaging in Vertebrates. Editors.

Vasilis Ntziachristos

Department of Radiology, Harvard University HMS/MGH, Charlestown, USA

Anne Leroy-Willig

U2R2M, CNRS and Université Paris-Sud, Orsay, France

Bertrand Tavitian

Unité d'Imagerie de l'Expression des Gènes, INSERM, Orsay, Franc

This book describes the new imaging techniques being developed to monitor physiological, cellular and subcellular function within living animals. This exciting field of imaging science brings together physics, chemistry, engineering, biology and medicine to yield powerful and versatile imaging approaches. By combining advanced non-invasive imaging technologies with new mechanisms for visualizing biochemical events and protein and gene function, non-invasive vertebrate imaging enables the in vivo study of biology and offers rapid routes from basic discovery to drug development and clinical application. Combined with the availability of an increasing number of animal models of human disease, and the ability to perform longitudinal studies of disease evolution and of the long-term effects of therapeutic procedures, this new technology offers the next generation of tools for biomedical research.

Well illustrated, largely in colour, the book reviews the most common and technologically advanced methods for vertebrate imaging, presented in a clear, comprehensive format. The basic principles are described, followed by several examples of the use of imaging in the study of living multicellular organisms, concentrating on small animal models of human diseases. The book illustrates:

· The types of information that can be obtained with modern in vivo imaging;

· The substitution of imaging methods for more destructive histological techniques;

· The advantages conferred by in vivo imaging in building a more accurate picture of the response of tissues to stimuli over time while significantly reducing the number of animals required for such studies.

Part 1 describes current techniques in in vivo imaging, providing specialists and laboratory scientists from all disciplines with clear and helpful information regarding the tools available for their specific research field. Part 2 looks in more detail at imaging organ development and function, covering the brain, heart, lung and others. Part 3 describes the use of imaging to monitor various new types of therapy, following the reaction in an individual organism over time, e.g. after gene or cell therapy.

Most chapters are written by teams of physicists and biologists, giving a balanced coherent description of each technique and its potential applications.

The book is aimed at a broad audience conducting research in areas such as biochemistry, physiology, developmental biology, oncology and pharmacology. While written primarily for those already engaged in imaging studies, it will also be of interest to scientists from other disciplines looking for an entry point into the field of in vivo imaging in small animals.

Résumé
This book describes the new imaging techniques being developed to monitor physiological, cellular and subcellular function within living animals. This exciting field of imaging science brings together physics, chemistry, engineering, biology and medicine to yield powerful and versatile imaging approaches. By combining advanced non-invasive imaging technologies with new mechanisms for visualizing biochemical events and protein and gene function, non-invasive vertebrate imaging enables the in vivo study of biology and offers rapid routes from basic discovery to drug development and clinical application. Combined with the availability of an increasing number of animal models of human disease, and the ability to perform longitudinal studies of disease evolution and of the long-term effects of therapeutic procedures, this new technology offers the next generation of tools for biomedical research. Well illustrated, largely in colour, the book reviews the most common and technologically advanced methods for vertebrate imaging, presented in a clear, comprehensive format. The basic principles are described, followed by several examples of the use of imaging in the study of living multicellular organisms, concentrating on small animal models of human diseases. The book illustrates:

• The types of information that can be obtained with modern in vivo imaging;
• The substitution of imaging methods for more destructive histological techniques;
• The advantages conferred by in vivo imaging in building a more accurate picture of the response of tissues to stimuli over time while significantly reducing the number of animals required for such studies.
  Part 1 describes current techniques in in vivo imaging, providing specialists and laboratory scientists from all disciplines with clear and helpful information regarding the tools available for their specific research field. Part 2 looks in more detail at imaging organ development and function, covering the brain, heart, lung and others. Part 3 describes the use of imaging to monitor various new types of therapy, following the reaction in an individual organism over time, e.g. after gene or cell therapy.

Mos…