TCTP/tpt1 - Remodeling Signaling from Stem Cell to Disease

This book highlights the role of the Translationally Controlled Tumor Protein (TCTP) in cell signaling, cell fate and the resulting connection to disease development. It begins by discussing the structure/function of TCTP, before exploring its role in different species ranging from plants to Drosophila and covering fields such as development, the cytoskeleton, cell division, DNA fragility and apoptosis.

In turn, the book's final section is devoted to the role of TCTP in disease, namely asthma and diverse cancers, and ultimately as a target for the treatment of malignancies. What is the common denominator between all these processes and why is TCTP necessary in order for them to occur, even in the worst case such as cancer? The book seeks to provide meaningful answers to this and other key questions. Presenting a broad and revealing view on the topic, it offers an informative guide for scientists and students alike.

Contenu

1. Introduction: role of TCTP from the stem cell to cell death and cancerAdam Telerman and Robert Amson (atelerman@gmail.com) 2. Structural insights into TCTP and its interactions with ligands and proteins.Nadine Assrir a, Florian Malarda, Ewen Lescop (Ewen.LESCOP@cnrs.fr) 3. Crystal structure of the protein complex between TCTP and bcl-xlJean Cavarelli (cava@igbmc.fr) 4. Phylogenetic conservation and Structure-Function analysis of TCTPBeatriz Xoconostle-Cázares and Roberto Ruiz-Medrano (rmedrano@cinvestav.mx) 5. The Translational Controlled Tumour Protein TCTP: Biological Functions andRegulationUlrich-Axel Bommer (ubommer@uow.edu.au) 6. Current understanding of the TCTP interactomeSiting Li and Feng Ge (gefeng@ihb.ac.cn) 7. Role and fate of TCTP in protein degradative pathwaysMichel Vidal (michel.vidal@umontpellier.fr) 8. Roles of the Translationally Controlled Tumor Protein (TCTP) in plant developmentBETSCH Léo, SAVARIN Julie, BENDAHMANE Mohammed, SZECSI Judit (mohammed.bendahmane@ens-lyon.fr) 9. Function of Translationally controlled tumor protein in organ growth: Lessons fromDrosophila studiesKwang-Wook Choi1*, Sung-Tae Hong1 and Thao Phuong Le1 (kchoi100@kaist.ac.kr) 10. Function of TCTP in Spider venomAndrea Senff -Ribeiro (senffribeiro@gmail.com) 11. TCTP in cell divisionMalgorzata Kloc and Jacek Kubiac (jacek.kubiak@univ-rennes1.fr) 12. Tctp in Neuronal Circuitry AssemblyCláudio Gouveia Roque and Christine E. Holt (cag2230@cumc.columbia.ed) 13. TCTP and the apoptotic machineryDavid W. Andrews (david.andrews.lab@gmail.com) 14. TCTP as a pharmacologic targetThomas Efferth (efferth@uni-mainz.de) 15. TCTP has a crucial role in the different stages of Prostate Cancer malignant progression Virginie Baylot, Sara Karaki and Palma Rocchi (palma.rocchi@inserm.fr) 16. TCTP: a therapeutic target in cancer Robert Amson and Adam Telerman (amson @noos.fr) 17. History of Histamine Releasing Factor (HRF)/Translationally Controlled Tumor Protein (TCTP) including a Potential Therapeutic Target in Asthma and AllergySusan M. MacDonald (smacdona@jhmi.edu) Conclusions and perspectives