T and B Lymphocytes: Recognition and Function

T and B Lymphocytes: Recognition and Function is the 16th volume of the 1979 ICN-UCLA Symposia on Molecular and Cellular Biology. This book is organized into seven sections, encompassing 74 chapters that summarize molecular level progress in the field of immunobiology. It emphasizes cell membrane, techniques developed for its analysis, and varied products of the major histocompatibility complex, as well as other receptors on cells of the immune system.
The book starts by describing two approaches for molecular association evaluation. First is the use of artificial membranes or lipid vesicles for the incorporation of antigens for recognition by T-lymphocytes both at the afferent and efferent levels. Second is the chemical crosslinking of cell surface components with a variety of different crosslinking reagents. This is followed by a discussion on the molecular nature of a T-cell receptor that provides insights of the target(s) recognized by T-lymphocytes. Several chapters discuss data dealing with the issue of the apparent differential recognition by T- and B-cells while both use the same VH genes. Antiidiotypic sera, together with the activity of ""regulator"" T-cells, are also discussed, with regard to their role in networks of regulation of the immune response.
This book presents works demonstrating that human T-lymphocytes can also be cloned and both noncytotoxic proliferating T-lymphocytes and Tc can be so obtained. This is along with the continuing studies regarding heterogenity of B-lymphocytes as well as macrophages. Part V focuses on the interaction between lymphocyte and virus and molecular modifications of viral-infected cells. The subsequent section deals with recognition, reactivities, and function of T- and B-lymphocytes. Considerable chapters in this section discuss T-cell cytotoxicity, dichotomy of MHC control over anti H-Y cytotoxic T-cell responses, mouse alloantibodies, and mixed lymphocyte reactions. The concluding part describes immunological tools, such as synthetic membranes and cloned T-cells with biological function.

Contenu

Contributors
Preface
I. Structure of the MHC and Gene Structure
A. Structure of the Molecular Products of the MHC

1. Role of the Structure of the Plasma Membrane's Cytoplasmic Face in Lymphocyte Function 1
2. Ia Antigen Cross-reactions between Species
3. Evidence That More than One Gene Locus Controls Expression of Human B-Cell Alloantigens 4. Structural Analysis of the I-A and I-E/C Alloantigens
4. H-2b Structure on Mouse Leukemia Cells
5. Workshop Summary: Chemistry of MHC Products
   B. Origin of Antibody Diversity
6. Genetic Mechanisms of Antibody Diversity in Balb/c Kappa Variable
   Regions
7. Workshop Summary: Origin of Antibody Diversity
   C. T- and B-Cell Markers and Differentiations
8. Development of T-Cells in the Mouse
9. T-Cell-Specific Murine Ia Antigens: Serology of I-J and I-E Subregion Specificities
10. B-Cell Lymphoma Lines as Potential Models for the Study of B-Cell Subpopulations
11. Characterization of a Non-H-2 Linked Gene Cluster Coding for the Murine B-Cell Alloantigens Lyb-2, Lyb-4, and Lyb-6
12. Workshop Summary: Markers of T- and B-Cell Differentiation
    II. Trigerring and Tolerance Via Receptor Interactions
    A. Early events in Lymphocyte Activation
13. Biochemistry of Lymphocyte Communication
14. Mechanism of Surface Membrane Expression in Murine B-Lymphocyte Cell Lines
15. Antibody Affinity in CBA/N Mice
    B. Role of Surface Immunoglobulin and of Antigen Receptors with B-Cell Triggering and Tolerance
16. Possible Antigen Specific T-Cell Help in Pokeweed Mitogen Stimulated Human Peripheral Blood Cell Cultures
17. Induction of T-Cell Proliferation by Antisera to the T-Cell Surface
18. Workshop Summary: Early Events, Triggering, and Tolerance
    C. Role of Antigen Binding Cells in the Immune Response
19. Antigen-Driven Alteration in Surface Ig Isotypes on Antigen-Binding Cells
20. High Frequency of Specific Antigen Binding Cells in Protein Antigen Stimulated Lymph Nodes
21. Workshop Summary: Role of the Antigen-Binding Cell in Immune Responses
    D. Self Tolerance and Autoimmunity
22. Restraints on Current Concepts of Self-Tolerance
23. Evidence for Irreversible Inactivation of B-Lymphocytes in Tolerance to T-Dependent Antigens
24. Suppressor Mechanisms in Tissue Transplantation Tolerance following Total Lymphoid Irradiation (TLI)
25. Genetic Control of Experimental Autoimmune Myasthenia Gravis in Mice
26. Workshop Summary: Discrimination between Self and Nonself
    III. Role of Macrophages in the Immune Response
27. Ir Gene Complementation in the Murine T-Lymphocyte Proliferative Response
28. Murine Macrophage-Lymphocyte Binding-Separation of B-Cell Subsets on Macrophage Monolayers
29. Workshop Summary: Role of Macrophages in the Initiation and Regulation of the Immune Response
    IV. Cell-Cell Interactions: Genetics and Mediators
    A. Cell-Cell Recognition and Regulation
30. Workshop Summary: Helper and Suppressor Epitopes
31. Multiple MHC Loci Controlling Lymphocyte Interactions
32. Effective Suppression of Hapten-Specific Delayed-Type Hypersensitivity (DTH) Responses in Mice by Anti-Idiotypic Antibodies
33. Allohelp to H-2K Appears to Depend Only on a Mature LY123 T-Cell
34. T-Cell Recognition of Syngeneic and Allogeneic H-2 Determinants
35. Workshop Summary: Cell-Cell Recognition and Regulation
    B. Mediators of Cell-Cell Interactions
36. On the Nature of Specific Factors and the Integration of Their Signals by Macrophages
37. Antigen and Receptor Stimulated Regulation. The Relationship of Idiotype and MHC Products to Regulatory Networks
38. Two T-Cell Signals Are Required for the B-Cell Response to Protein-Bound Antigens
39. Helper T-Cells Expressing an I-J Subregion Gene Product
40. Purification and B-Cell Triggering Properties of Antigen Specific T-Cell Derived Helper Factors
41. Workshop Summary: Mediators of Cell-Cell Interactions
    C. Network of Regulation
42. What Is the Nature of the Antigenic Complex Recognized by T-Lymphocytes?
43. Idiotype and Antigenic Specificity of Th , Ts , and B-Cells Induced by Hen Egg-White Lysozyme
44. Cellular Basis of the Regulation of Production of Anti-TNP Antibodies Carrying MOPC460 Idiotype
45. Workshop Summary: Network of Regulation Constantin Bona and Alfred Nisonoff
    D. Antigen-Binding Receptors
46. Specific Autoimmunity during the Immune Response: Idiotypes and Antigen-Binding Specificity of Antibodies and T-Cell Receptors
47. Isolation and Preliminary Characterization of Hapten Reactive Molecules from Affinity-Enriched Azobenzenearsonate-Specific T-Cells
48. Specific Target Cell Lysis by Supernatants Derived from Alloimmune Murine Cytotoxic T-Lymphocytes: Possible Role of a Lymphotoxin-T-Cell Receptor Complex
49. Workshop Summary: Molecular and Cellular Characterization of Antigen-Binding Receptors
    V. Virus-Lymphocyte Interrelationship
    A. Lymphocyte-Virus Interaction
50. Molecular Modifications in VSV-Infected Cells
51. Altered Expression of T-Lymphoid Cell Surface Antigens Associated with Viral Infection
    B. Learning of H-2 Restriction
52. MHC-Restriction and Differentiation of T-Cells
53. H-2 Linked Resistance to Spontaneous AKR Leukemia: A Mechanism
54. Workshop Summary: Learning of H-2 Restriction and Lymphocyte-Virus Interactions
    VI. Lymphocyte Recognition and Function
    A. Genetics of Cell-Cell Interaction with Cell-Mediated Lympholysis
55. T-Lymphocyte Reactivities to Alio- and Altered-Self Antigens
56. T-Cell Cytotoxicity in Mice Elicited by Immunization with Syngeneic Tumor Cells Induced by Different Strains of Mouse Leukemia Viruses
57. Dichotomy of MHC Control Over Anti-H-Y Cytotoxic T-Cell Responses
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