Synaptic Constituents in Health and Disease

Synaptic Constituents in Health and Disease is a collection of papers from the Proceedings of the Third Meeting of the European Society for Neurochemistry held in Yugoslavia, on August 31-September 5, 1980. This collection deals with gene analysis, the diagnosis, and treatment of inherent errors in metabolism. One paper discusses the role of vesicles in cholinergic systems in terms of the vesicle hypothesis or the cytosol hypothesis. Another paper focuses on the molecular organization of chromaffin granulles-the catecholamine-storing vesicles of the adrenal medulla. One author discusses the interaction between antibodies and receptors in receptors such as insulin, TSH, prolactin, or estrogens. Another paper examines the occurrence and postulated functions of trans-synaptic structures to find out whether some kind of structural continuity exists, beyond mere contact, between the plasma membranes of two synapsing neurons. One other paper shows that morphological evidences of damage on nerve cells in some brain areas are found after gerbils inhaling an industrial solvent, trichloroethylene (TCE), The paper also discusses general topics in neurochemistry such as the DNA turnover in rat cerebral cortex. This collection can prove invaluable for biologists, medical and chemical researchers, molecular scientists, and the neuro-chemist investigators.

Contenu

Introductory Lecture

Gene Analysis and the Diagnosis and Treatment of Inborn Errors of Metabolism

Symposium Molecular Aspects of the Storage and Release of Neurotransmitters Chairman

The Role of Vesicles in Cholinergic Systems

Molecular Organization of Catecholaminestoring Organelles

Current Knowledge of the Storage and Release of Transmitter Candidate Amino Acids and Neuropeptides

Cyclic Nucleotides, Calcium Ions and Protein Phosphorylation in Neurotransmission

Posters

Precursors of Acetyl Groups of Acetylcholine and the Role of Acetyl-CoA in the Control of Acetylcholine Synthesis

Effect of Sialidase Treatment Upon Choline Uptake into a Synaptosomal Preparation of Rat Brain

Effects of Acute Choline Administration on Pharmacologically Induced Alterations in Central Cholinergic Neurons

The Effect of Extraneuronal Acetylcholine (ACh) on the Rate of ACh Release from the Auerbach Plexus of Guinea Pig Ileum

Serotonin-Accumulating Neurones in Retina

Effect of Maprotiline on Serotonin in Rat Brain and in Human Platelets

Inhibition of Serotonin Uptake into Spleen by a Beta-adrenoreceptor Agonist: Salbutamol

Adrenaline and Noradrenaline Release from 2 Subpopulations of Bovine Chromaffin Granules

Hydrophilic and Amphiphilic Forms of Dopamine ß-Hydroxylase in Early and Mature Stages of the Bovine Adrenomedullary Granules Sugar Composition and Immunological Characterisation of Glycoproteins of Chromaffin Granules

Effect of GABA on Spontaneous and Evoked Release of 3H-NA from Synaptosomes of Rat Brain Mesodiencephalic Region

Effect of Bicuculline, -Aminobutyric Acid and Ca2+ on the Release of 3H-Noradrenaline and 14C- -Aminobutyric Acid from Slices of Rat Brain Mesodiencephalic Region

The Effect of Ethanol and Acetaldehyde on GABA Transport Systems and Its Synthesis in Rat Brain Synaptosomes

Pharmacology of GABA Autoreceptors

[3H] L-Glutamate and [3H]-Glutamine Uptake: an Autoradiographic Study in the Developing Rat Cerebellum

Neurotransmitter Amino Acid Uptake in Human Cerebral Tissue In Vitro

Release of Endogenous Amino Acids from Rabbit Superior Colliculus

Estimation of Release and Uptake of Glutamate by Hippocampal Slices Using Modified Microcup Technique

Effects of Adenosine Derivates on the Uptake and Release of L-Glutamate in Rat Brain Synaptosomes

Calcium Activation of Synaptosomal Glutaminase

Adenosine Release from Guinea-Pig Neocortex Synaptosome Beds

Oxidation of Hypotaurine in Brain and Liver of Developing Mice

Effects of Structural Analogues and Drugs on Hypotaurine Uptake in Brain Slices

Taurine Uptake in Developing Retina

Taurine Exit from Cerebral Cortex Slice Stimulated by Sodium-Deficient Medium

Transmitter Inactivation in Primary Cell Cultures

Workshop Current Status of the Vesicular Hypothesis for ACh Release Organizer

ACh Release and Synaptic Vesicles

Reversibility of Transmitter Release

The Vesicular Hypothesis Examined by Measuring Acetylcholine with a Fast Freezing Method

Incorporation of Acetylcholine into Torpedo Synaptic Vesicles In Vitro

De Novo Formation of Synaptic Vesicles in the Superior Cervical Ganglion of Cat

Are Vesicles Fusing with the Presynaptic Plasma Membrane upon Electrical Stimulation of the Electromotor Synapses of Torpedo Marmorata?

Posters

Nucleotide Transport into Isolated Cholinergic Synaptic Vesicles

into and 3H-Acetylcholine Release from Brain Tissue by Tetanus and Botulinum A Toxin

The Effect of the Black Widow Spider Venom on the free, Bound and Total Acetylcholine Content in Mouse Brain

Workshop Receptor Pharmacology

Organizer

The Use of Antibodies in Receptor Studies

Wolosin: Current Views on the Structure of Nicotinic Acetylcholine Receptors from Different Sources

Alpha Adrenergic Receptors in the Vascular Smooth Muscle

Pharmacological Characterization of GABA Receptors

Posters

Does The Affinity of Quaternary Compounds Depend on the Presence of the Ester Group

Distribution and Localization of Muscarinic Receptors in the 24 Hour Post Hatch Chick Brain

An Immunofluorescence Study of a-Bungarotoxin Receptors in the Rat Superior Cervical Ganglion

On the Neurotoxin Binding Site Acetylcholine Receptor Protein

Mechanism of Action of Crotoxin on the Postsynaptic Membrane

Factors Controlling the Duration of Postsynaptic Response

Iontophoretically Evoked Responses during Repetitive Stimulation in the Frog Neuromuscular Junction

Analysis of Fluctuations Produced by Acetylcholine and Its Analogues in Neurones of Mollusc Limnaea Stagnalis

Effect of ß-Carbolines on Brain Cholinergic System

Monoamine Neurotransmitters and Scopolamine Treatment-Neurochemical Studies

Effect of Cholinergic and Adrenergic Stimulation on Calcium Efflux from Glioma Cultured Cells

Interactions between Cholinergic and Adrenergic Systems in the Rabbit Hypothalamus

Changes in Alpha2 Adrenoreceptor Density after Chronic Treatment with Imipramine

Action of Imipramine on Noradrenaline Uptake, Noradrenergic Receptors and Adenylate Cyclase

The Effect of Propranolol on the Porphyrin Synthesis of Chick Embryo Brain Tissue Culture

On Effects of Ca-Binding Proteins and Biogenic Amines

Mg, Ca-ATPase of Synaptic Membranes and Biogenic Amines

Biomolecular Information in Adrenergic Ligands

Central Dopamine Receptor Ligand Topography

Dopamine and Synthesis of Hippocampal Glycoproteins

Is There a Relation between the Striatal Dopamine-Susceptible Na, K-ATPase Activity and Dopamine Receptors

Development of Supersensitive State on Dopaminergic Receptors after the Acute Administration of Neuroleptic Drug Isofloxythepin

Changes in Striatal and Mesolimbic Dopamine Receptors after Single In Vivo Administration of Morphine

Effects of Drugs Affecting Serotonergic System on Activities of Central Dopaminergic and Serotonergic Systems in Rats

The Effect of 5-Hydroxytryptamine on Aggressive Behavior and Convulsions Caused by Cholinomimetics and Anticholinesterases in Conscious Cats

Metabolic Changes in Dentate Gyrus Following Denervation of the Perforant Path

Glutamate Decarboxylase in the Rat Thyroid Gland and GABA Binding Processes in Rat Brain

Regulation of GABA Receptor Binding to Synaptic Plasma Membrane of…