Substance Use Disorders

The purpose of this book is to provide a broad scope of substance use disorder research and how these findings can impact treatment outcomes. The research and outcomes described in this book represent important principles related to identifying and understanding factors related to substance use disorders. The first section is dedicated to methodology including population-based surveys, basic neuroanatomy, chemistry, molecular biology, behavioral models and brain imaging. The second section utilizes this methodology in research related to opioids, cocaine, marijuana, alcohol and nicotine. The book is aimed at both professionals (academics, clinicians, practitioners) and students or trainees.

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1. Methods for Population Research on Substance Use and Consequences

Mark Wolfson, Kimberly G. Wagoner, Eunyoung Y. Song, Melinda Pankratz, Sunday Azagba

2. Translational Molecular Approaches in Substance Abuse Research

Sasha L. Fulton and Ian Maze

3. Small Molecule Neuropeptide-S and Melanocortin Receptor Ligands As Potential Treatments for Substance Use Disorders

Bruce Blough and Ojas Namjoshi

4. Emerging Insights into Mu Opioid Pharmacology

Gavril W. Pasternak, Steven R. Childers, and Ying-Xian Pan

5. Behavioral Pharmacology of Drugs Acting at Mu Opioid Receptors

Lisa R. Gerak, David R. Maguire, and Charles P. France

6. The Rise and Fall of Kappa-Opioid Receptors in Drug Abuse Research

Matthew L. Banks

7. Clinical Trials for Opioid Use Disorder

Esther Blessing, Sanya Virani, and John Rotrosen

8. Modelling Differential Vulnerability to Substance Use Disorder in Rodents: Neurobiological Mechanisms

Bianca Jupp, Jolyon A. Jones, and Jeffrey W. Dalley

9. Activity-Dependent Epigenetic Remodeling in Cocaine Use Disorder

Alberto J. López, Cody A. Siciliano, and Erin S. Calipari

10. Molecular Mechanisms of Amphetamines

Maarten E. A. Reith and Margaret E. Gnegy

11. Clinical Trials for Stimulant Use Disorders: Addressing Heterogeneities That May Undermine Treatment Outcomes Paul S. Regier, Kyle M. Kampman, and Anna Rose Childress

12. Molecular Mechanism and Cannabinoid Pharmacology

Lesley D. Schurman, Dai Lu, Debra A. Kendall, Allyn C. Howlett, 3 and Aron H. Lichtman

13. Pharmacotherapies for Cannabis Use Disorders: Clinical Challenges and Promising Therapeutic Agents

Suzanne Nielsen, Pamela Sabioni, Linda Gowing, and Bernard Le Foll

14. Molecular Mechanisms Associated with Nicotine Pharmacology and Dependence

Christie D. Fowler, Jill R. Turner, and M. Imad Damaj

15. Randomized Clinical Trials Investigating Innovative Interventions for Smoking Cessation in the Last Decade

Marie N. S. Gendy, Christine Ibrahim, Matthew E. Sloan, and Bernard Le Foll

16. Adolescent Vulnerability to Alcohol Use Disorder: Neurophysiological Mechanisms from Preclinical Studies

Brian A. McCool and Molly M. McGinnis 17. Medication Development for Alcohol Use Disorder: A Focus on Clinical Studies

Lorenzo Leggio, Daniel E. Falk, Megan L. Ryan, Joanne Fertig, 3 and Raye Z. Litten

18. Newly Emerging Drugs of Abuse

Kenichi Tamama and Michael J. Lynch