Structure and Function of Sarcoplasmic Reticulum

Structure and Function of Sarcoplasmic Reticulum is a compendium of papers from an International Conference on Sarcoplasmic Reticulum held in Japan on November 1-4, 1982. Section I is a review of sarcoplasmic reticulum including the "discovery" of the relaxing factor, the calcium binding of relaxing factor, as well as phosphate transfer and calcium transport coupling. Section II involves the chemistry and structure of the calcium pump protein in sarcoplasmic reticulum. One paper describes the role of protein-lipid interactions in the organization and function of biomembranes. Section III considers the kinetics and thermodynamics of the calcium pumping mechanism, particularly the binding of ligands to calcium ATPase of the sarcoplasmic reticulum, as well as the conformational changes of the sarcoplasmic reticulum Ca-ATPase induced by substrate binding and phosphorylation. A paper gives the results of several experimental techniques in substrates binding assays employing millipore filters and a thermostated filtration apparatus. Section IV describes the calcium ions release process such as rapid and reversible actions, while Section V discusses the regulation of calcium ions uptake and release in the ion channel vesicles. This book can be helpful for researchers in biophysical engineering, pharmacologists, and scientists in the fields of biochemistry and biophysics.

Contenu

Contributors
Preface
Yuji Tonomura (1923-1982)
Section I Historical Background and Overview
Relaxing Factor, Sarcoplasmic Reticulum, and Troponin - A Historical Survey
The Sarcoplasmic Reticulum Calcium Pump: Early and Recent Developments Critically Overviewed
Section II Chemistry and Ultrastructure of the Calcium Pump Protein in Sacroplasmic Reticulum
Static and Time-Resolved Structural Studies of the Ca2 + -ATPase of Isolated Sarcoplasmic Reticulum
Conformational Changes of Ca2+,Mg2+-Adenosinetriphosphatase as Detected by Site-Specifically Introduced Fluorescent andParamagnetic Probes and by Susceptibility to Tryptic Digestion
Structural Analysis of the Ca2+,Mg2+-ATPase of Sarcoplasmic Reticulum
Protein-Lipid Interaction in Sarcoplasmic Reticulum and Phospholipid-Replaced Membranes
Sarcoplasmic Reticulum and Other Membranes in the Regulation of Skeletal Muscle Contraction and Relaxation: A Multilevel Approach
A New Procedure for the Reconstitution of Sarcoplasmic Reticulum Vesicles by Salting-Out Method
Target Size of Calcium Pump Protein from Skeletal Muscle Sarcoplasmic Reticulum
Oligomeric Form of the Ca2+,Mg2+-Dependent ATPase in Sarcoplasmic Reticulum
Section III Kinetics and Thermodynamics of the Calcium Pumping Mechanism
A. Thermodynamic and Kinetic Considerations
Binding of Ligands to Calcium ATPase of the Sarcoplasmic Reticulum
Equilibrium and Kinetic Correlations of the Partial Reactions of the Ca2 + Transport Cycle
Kinetic and Thermodynamic Aspects of ATP-Dependent Ca2+ Transport in Sarcoplasmic Reticulum Using ATPßS Diastereomers as Substrates
Conformational Changes of the Sarcoplasmic Reticulum Ca-ATPase Induced by Substrate Binding and Phosphorylation
Conformational Change of SR-ATPase Induced by Phosphorylation
Mechanism for the Interconversion of Chemical and Osmotic Free Energy
B. Kinetic Studies of the Calcium Pumping Cycle
Kinetics of Accumulation of the ADP-Sensitive and ADP-Insensitive Phosphoenzymes and Their Relationship to Ca2+ Translocation in Sarcoplasmic Reticulum
Pre-Steady State Kinetics of E~P Formation and Decomposition by Ca2+,Mg2 + -ATPase in Bovine Aorta Microsomes
Theoretical Basis for the Sequence Analysis of the Reaction Steps Involved in the Transphosphorylation Process of the Sarcoplasmic Ca + +-Transport ATPase
Ca2 + -Ca2 + Exchange Mediated by the Membrane-Bound Ca2+,Mg2+-ATPase of Sarcoplasmic Reticulum Vesicles
Reaction Mechanism of ATP Hydrolysis by Sarcoplasmic Reticulum with CaATP as a Substrate
Mechanism of ATP Synthesis in Sarcoplasmic Reticulum
The Ca-ATPase of Sarcoplasmic Reticulum Catalyses a Monovalent Cation (Na,K) Exchange
Section IV The Ca2+ Release Process
Rapid and Reversible Calcium Release from Sarcoplasmic Reticulum In Vitro
Mechanism of Calcium Release from Sarcoplasmic Reticulum: Effect of Caffeine on Magnesium Binding to Fragmented Sarcoplasmic Reticulum from Bullfrog Skeletal Muscle
Ca Releasing Action of Quercetin on the Sarcoplasmic Reticulum of Frog Skeletal Muscle
The Effects of Adenine Nucleotide and External Ca2+ on Ca2+ Release from Fragmented Sarcoplasmic Reticulum in the Presence of Mg2
Calcium-Induced Calcium Release from Fragmented Sarcoplasmic Reticulum
Calcium Impulse
Appraisal of the Hypothesis of the "Depolarization-Induced" Release of Calcium from the Sarcoplasmic Reticulum in Skinned Cardiac Cells from the Rat or Pigeon Ventricle
The Calcium-Induced Calcium Release from the Sarcoplasmic Reticulum
Section V Regulation of Ca2+ Uptake and Release
Ion Channels of Sarcoplasmic Reticulum Vesicles and Calcium Release
Regulation of Ca2+ Pumping in Heart Sarcoplasmic Reticulum
Resolution of the Regulatory Systems of the Cardiac Sarcoplasmic Reticulum Ca2+,Mg2+ -ATPase
Index