Schering Workshop on Pharmacokinetics, Berlin, May 8 and 9, 1969

Advances in the Biosciences 5: Schering Workshop on Pharmacokinetics, Berlin, May 8 and 9, 1969 is a collection of papers presented at the Schering Workshop on Pharmacokinetics held in Berlin, Germany, on May 8 and 9, 1969. Contributors focus on advances in the field of pharmacokinetics, including the use of digital computers in defining pharmacokinetic parameters and of mathematical models in the study of steroid dynamics. The pharmacokinetics of acetazolamide and endogenous substances is also described.
This book is comprised of 19 chapters and begins with an overview of the basic concepts and experimental methods of pharmacokinetics, followed by a discussion on the general physico-chemical aspects of drug distribution. Subsequent chapters explore multiple dose elimination kinetics and drug accumulation in patients with normal and impaired kidney function; the application of analog and digital computers in pharmacokinetics; use of mathematical tools in defining pharmacokinetic parameters; and measurement of enteric absorption rate using a double tracer technique. Mathematical and statistical problems in pharmacokinetics are also presented.
This monograph will be a useful resource for pharmacologists and biologists.

Contenu

Introduction
Opening
Basic Concepts and Experimental Methods of Pharmacokinetics
General Physico-Chemical Aspects of Drug Distribution
Multiple Dose Elimination Kinetics and Drug Accumulation in Patients with Normal and with Impaired Kidney Function
The Application of the Analog Computer in Pharmacokinetics
Use of Digital Computers in Defining Pharmacokinetic Parameters
Use of Mathematical Tools in Defining Pharmacokinetic Parameters
Mathematical and Statistical Problems in Pharmacokinetics
The Formulation of Models to explain Blood and Tissue Data on Distribution of Drugs and Tracers (With special Reference to Multi-Compartment Models)
An Explicit Function for Rate Constant of Entrance Concerning a Two-Compartment-Model
Mathematical Models in the Study of Steroid Dynamics
The Measurement of Enteric Absorption Rate using a Double Tracer Technique
The Systematic Influence of Elimination
Pharmacokinetics of Endogenous Substances
The Pharmacokinetics of Acetazolamide in Relation to Its Use in the Treatment of Glaucoma and to Its Effects as an Inhibitor of Carbonic Anhydrases
Pharmacokinetics in Clinical Drug Research
Pharmacokinetics of Human Drug Research
Panel Discussion
Closing Address
Lecturers
Participants