Antibiotic Resistant Bacteria: A Challenge to Modern Medicine

This book summarizes the emerging trends in the field of antibiotic resistance of various gram-negative and gram-positive bacterial species. The ability of different species of bacteria to resist the antimicrobial agent has become a global problem. As such, the book provides a comprehensive overview of the advances in our understanding of the origin and mechanism of resistance, discusses the modern concept of the biochemical and genetic basis of antibacterial resistance and highlights the clinical and economic implications of the increased prevalence of antimicrobial resistant pathogens and their ecotoxic effects. It also reviews various strategies to curtail the emergence and examines a number of innovative therapeutic approaches, such as CRISPR, phage therapy, nanoparticles and natural antimicrobials, to combat the spread of resistance.

Auteur

Sadhana Sagar is working as teaching faculty at Rani Lakshmi Bai Central Agricultural University, Jhansi, India. Previously, she has received her Ph.D. in Environmental Microbiology from Babasaheb Bhimrao Ambedkar University, Lucknow, India. She is working on bacteriophage-mediated control of Multiple Drug Resistant bacteria. She has published numerous research and review articles in various reputed national and international journals and has presented numerous papers at national and international conferences. Shilpa Deshpande Kaistha received her Ph.D. in Microbiology from University of Tennessee, Knoxville, TN, USA in 2000. She has been working as a faculty in the Department of Microbiology, Institute of Biosciences & Biotechnology, Chhatrapati Shahuji Maharaj University, Kanpur for the last 15 years and actively pursues her pedagogical passions. Her research interests include understanding the role of microbial biofilms^1200 google scholar citations, h-index 20) and several book chapters. She has received several awards including the Keystone Symposia Fellowship and DAE Young Scientist Research Award. Amar Jyoti Das is a research scholar pursuing his Ph.D. from the Department of Environmental Microbiology at the Babasaheb Bhimrao Ambedkar University, A Central University Lucknow, India. He is a dual gold medalist in M.Sc Environmental Microbiology and has received DST Inspire (JRF & SRF) for pursuing Doctorate degree. His research interests include Environmental Microbiology, Industrial Microbiology, plant-microbe interactions, and abiotic stress management. He has published numerous research and review articles in reputed national and international journals. He has won several best presentation and best work awards at various national and international conferences and symposiums.

Prof. Rajesh Kumar, a doctorate in Microbiology from prestigious Indian Agricultural Research Institute, New Delhi, working as a Professor and Head of the Department of Microbiology at Babasaheb Bhimrao Ambedkar University (BBAU), A Central University, Lucknow, India. Prior to this, he worked as Associate Professor and Coordinator, Nanoscience and Nanotechnology at BBAU and worked in Department of Microbiology at G.B. Pant University of Agriculture and Technology, Pantnagar, India for 11 years. He has been teaching various PG courses in Microbiology and has been awarded the prestigious Indian National Science Academy Visiting Fellowship, Senior Research Fellowship and Young Scientist Fellowship. His research interest includes plant-microbe interaction, abiotic stress management, immuno- and nanosensor development for environmental monitoring. He has published numerous research and review articles in the reputed national and international journal, authored a book on biosurfactants and has presented numerous papers at the conferences. He is a reviewer of many reputed international journals and has been awarded Innovator of the year for his work on nanomaterial synthesis using reverse micelle process at Kasetsart University, Bangkok, Thailand in the year 2016.

Contenu
Chapter 1. Emergence of antibiotic resistant bacteria.- Chapter 1.1. Era of antibiotic discovery.- Chapter 1.2. Emergence of antibiotic resistant microbes immediate after the discovery of antibiotics.- Chapter 1.3. Newly discovered antibiotics of 21st century.- Chapter 2. Impact of antibiotic resistant bacteria on different field.- Chapter 2.1. Antibiotic resistance: Role and pattern in different class of bacteria.- Chapter 2.2. Effect of drug resistant bacteria on agriculture, medical society, livestock and environment.- Chapter 3. Antibiotic resistance: Pattern and Mechanisms.- Chapter 3.1. Intrinsic antibiotic resistant mechanism in bacteria.- Chapter 3.2. Extrinsic antibiotic resistant mechanism in bacteria .- Chapter 3.3. Chemical mediated alteration of antibiotics.- Chapter 4.1. Novel strategies for overcoming of antibiotic resistant mechanisms.- Chapter 4.2. Collapsing of antibiotic resistance with the help of genetic approaches.- Chapter 4.3. Bacteriophage: A new hope for the control of antibiotic resistant bacteria.- Chapter 4.4. Nanotechnology: A 21st Century approach towards the control of antibiotic resistant bacteria.- Chapter 5. Future Prospects.