This book explores the concept of S-Risks, or suffering risks, and delves into their significance, distinguishing them from conspiracy theories and alarmism. It categorizes S-Risks into agential, natural, and incidental types, discussing the disjunctive nature and various factors influencing them. Examining technological progress, the existence of powerful agents, and unintended consequences, the book addresses societal values, ethical considerations, and specific risks like COVID-19, gain-of-function research, computer hacking, and social media impact. It thoroughly covers AI-related S-Risks, existential risks, misincentives, goal misalignment, adversarial AI, autonomous weapons, economic disruptions, surveillance, and privacy concerns. Additionally, it explores S-Risks associated with climate change, energy, activism, natural disasters, biological engineering, quantum technological outcomes, cosmic phenomena, social and economic experiments, cultural or memetic risks, and global consciousness networks. The book concludes by proposing a classification system for S-Risks and grouping S-Risk profiles.