Redox Signaling and Biomarkers in Ageing

This book aims to present the age-related alterations in redox signaling networks and their diagnostic biomarkers in aging cells using multidisciplinary approach. Establishing sensitive and specific biomarkers of dynamic redox homeostasis is crucially important in the development of effective antiaging and senolytic interventions. Recent years have seen tremendous advances in the understanding of redox signaling events which highlight the process of aging and age-related pathologies. A major challenge in biological aging research is developing reliable biomarkers to determine the consequences of disrupted redox signaling networks long before the clinical diagnosis of age-related diseases is made. Therefore, we have chosen to concentrate on aging-induced aberrant redox signaling networks, their biomarkers, and pathological consequences in this book.

Although oxidation is a natural metabolic process, the imbalance in the level of oxidants and antioxidants causes oxidative stress and eventually leads to inflammatory conditions, diabetes, neurodegenerative diseases, and cancer. Novel redox-sensitive biomarkers for the evaluation of aging-induced proteinopathies such as amyloid ß and tau proteins in Alzheimer's disease, a-synuclein in Parkinson's disease, and islet amyloid polypeptides in type 2 diabetes mellitus recently drew the attention of researchers.

Inside this textbook, readers will find comprehensive perspectives on the association between redox homeostasis and the aging process both at the molecular and clinical levels. Due to the inherent relationship between impaired metabolic activities and oxidative stress, the temporal interaction between intermediary metabolism and disturbed redox status can lead to greater susceptibility to aging-induced diseases and disorders, such as cardiovascular diseases, hypertension, and diabetes. This knowledge could be a key to continued research toward improving medication regimens such as in cancer and cardiovascular therapies, and procedural outcomes for patients.

This book brings together current research evidence and knowledge on redox signaling and biomarkers in aging in chapters written by leading global experts in this rapidly evolving field. We hope that this textbook is of interest to a wide group of researchers, advanced students, scientifically curious non-specialist readers and clinicians alike.

Auteur

About the editorDr. Ufuk Çakatay is a tenured professor of medical biochemistry and a senior scientist at Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, in Istanbul, Turkey. His research interests include the optimization of various bioanalytical methods to measure the levels of redox status biomarkers in aging tissues as well as anti-aging interventions, establishment experimental animal models for aging studies and redoxtasis in age-related disorders.

He has a long-standing interest in oxidative protein damage and proteostasis biomarkers. In addition, Professor Çakatay has a deep interest in mentoring medical students and fostering their research career. Professor Çakatay has authored more than 100 publications in several leading journals, which include research papers, book chapters, editorials and invited reviews on free radical biology, aging, diabetes, and biological activity of alpha-lipoic acid. He has served as a guest editor, referee or member of the editorial board for more than 50 journals. He has received various prestigious awards such as the top reviewer award from Elsevier Science Publishing and previously served as a committee member in Istanbul University's Committee on Animal Research and Ethics.

Contenu

Section 1: REDOX DYNAMIC HOMEOSTASIS

Chapter 1: Redox dynamic homeostasis and aging

Chapter 2: Intrinsic and extrinsic factors associated with redox homeostasis and biological aging

Chapter 3: Disturbed redox homeostasis in the aging brain

Chapter 4: Impaired redox homeostasis in cardiovascular aging Chapter 5: Redox homeostasis status influences skeletal muscle aging

Chapter 6: Aging, exercise and redox homeostasis

ection 2: REDOX SIGNALLING NETWORKS AND SUBCELLULAR SENESCENCE

Chapter 7: Redox signaling, autophagy and, aging

Chapter 8: Strategies to fight mitochondria and redox dyshomeostasis in physiological and pathological brain aging

Chapter 9: Protein redox status in subcellular aging

Chapter 10: Modulation of redox and aging related signaling and biomarkers by peptides or polysaccharides.

Chapter 11: Senolytic phytocompounds in redox signaling

Chapter 12: Reliability and longevity of biological systems: free-radical redox timer of genetic program

Section 3: REDOX STATUS BIOMARKERS IN AGING

Chapter 13: Intrinsic and extrinsic factors associated with redox imbalance and pathological aging Chapter 14: AI and deep learning in the study of redox biomarkers and aging

Section 4: REDOX STATUS IN AGE-RELATED DISORDERS Chapter 15: Impaired redox status and age-related neurodegenerative disorders

Chapter 16: The association between the redox biomarkers and white matter changes in aging brain

Chapter 17: Redox homeostasis in Alzheimer's disease

Chapter 18: Redox status in cerebrovascular diseases and atherosclerosis

Chapter 19 Redox biomarkers and stroke induced brain aging

Chapter 20: Redox status in age-related acute mesenteric ischemia

Chapter: 21: Aging and redox pathways in diabetes

Chapter 22: Redox biomarkers and aging in the acute setting