Chemistry of Bioconjugates

Explores bioconjugate properties and applications of
polymers, dendrimers, lipids, nanoparticles, and nanotubes

Bioconjugation has enabled breakthroughs across many areas of
industry and biomedicine. With its emphasis on synthesis,
properties and applications, this book enables readers to
understand the connection between chemistry and the biological
application of bioconjugated materials. Its detailed descriptions
of methods make it possible for researchers to fabricate and take
full advantage of bioconjugates for a broad range of applications.
Moreover, the book sets the foundation for the development of new
applications, including assays, imaging, biosensors, drug delivery,
and diagnostics.

Chemistry of Bioconjugates features contributions from an
international team of leading experts and pioneers in the field.
These contributions reflect the authors' firsthand laboratory
experience as well as a thorough review of the current literature.
The book's six sections examine:

• General methods of bioconjugation

• Polymer bioconjugates

• Organic nanoparticle-based bioconjugates

• Inorganic nanomaterial bioconjugates, including metals and
  metal oxides

• Cell-based, hydrogel/microgel, and glyco-bioconjugates

• Characterization, physico-(bio)chemical properties, and
  applications of bioconjugates

This comprehensive exploration of bioconjugates includes
discussions of polymers, dendrimers, lipids, nanoparticles, and
nanotubes. References at the end of each chapter serve as a gateway
to the most important original research findings and reviews in the
field.

By drawing together and analyzing all the latest chemical
methods and research findings on the physico-chemical and
biochemical properties of bioconjugates, Chemistry of
Bioconjugates sheds new light on the significance and potential
of bioconjugation. The book is recommended for organic and polymer
chemists, biochemists, biomaterial scientists, carbohydrate
chemists, biophysicists, bioengineers, and drug and gene delivery
scientists.

Auteur

RAVIN NARAIN, PhD, is Associate Professor in the
Department of Chemical and Materials Engineering at the University
of Alberta. He has published more than 100 articles in
peer-reviewed journals and is the editor of Engineered
Carbohydrate-Based Materials for Biomedical Applications
(Wiley). Dr. Narain's research examines nanomedicine and
regenerative medicine, with an emphasis on developing new
biomaterials for gene delivery and tissue engineering.

Résumé

Explores bioconjugate properties and applications of polymers, dendrimers, lipids, nanoparticles, and nanotubes

Bioconjugation has enabled breakthroughs across many areas of industry and biomedicine. With its emphasis on synthesis, properties and applications, this book enables readers to understand the connection between chemistry and the biological application of bioconjugated materials. Its detailed descriptions of methods make it possible for researchers to fabricate and take full advantage of bioconjugates for a broad range of applications. Moreover, the book sets the foundation for the development of new applications, including assays, imaging, biosensors, drug delivery, and diagnostics.

Chemistry of Bioconjugates features contributions from an international team of leading experts and pioneers in the field. These contributions reflect the authors' firsthand laboratory experience as well as a thorough review of the current literature. The book's six sections examine:

• General methods of bioconjugation
• Polymer bioconjugates
• Organic nanoparticle-based bioconjugates
• Inorganic nanomaterial bioconjugates, including metals and metal oxides
• Cell-based, hydrogel/microgel, and glyco-bioconjugates
• Characterization, physico-(bio)chemical properties, and applications of bioconjugates
  This comprehensive exploration of bioconjugates includes discussions of polymers, dendrimers, lipids, nanoparticles, and nanotubes. References at the end of each chapter serve as a gateway to the most important original research findings and reviews in the field.

By drawing together and analyzing all the latest chemical methods and research findings on the physico-chemical and biochemical properties of bioconjugates, Chemistry of Bioconjugates sheds new light on the significance and potential of bioconjugation. The book is recommended for organic and polymer chemists, biochemists, biomaterial scientists, carbohydrate chemists, biophysicists, bioengineers, and drug and gene delivery scientists.

Contenu

PREFACE vii

CONTRIBUTORS ix

SECTION I GENERAL METHODS OF BIOCONJUGATION

1 Covalent and Noncovalent Bioconjugation Strategies 3

Rajesh Sunasee and Ravin Narain

SECTION II POLYMER BIOCONJUGATES

2 Bioconjugates Based on Poly(Ethylene Glycol)s and
Polyglycerols 79

Rajesh A. Shenoi, Fang Gao, Muhammad Imran ul-Haq, and
Jayachandran N. Kizhakkedathu

3 Synthetic Polymer Bioconjugate Systems 104

Marya Ahmed and Ravin Narain

4 Natural Polymer Bioconjugate Systems 133

Lichao Liu, Xiuwei Pan, and Weian Zhang

5 Dendrimer Bioconjugates: Synthesis and Applications 146

Ali Nazemi and Elizabeth R. Gillies

SECTION III ORGANIC NANOPARTICLES BASED BIOCONJUGATES

6 Bioconjugation Strategies: Lipids, Liposomes, Polymersomes,
and Microbubbles 187

Anirban Sen Gupta and Horst A. von Recum

7 Organic Nanoparticle Bioconjugate: Micelles, Cross-Linked
Micelles, and Nanogels 203

Maria Vamvakaki

8 Carbon Nanotubes and Fullerene C60 Bioconjugates 239

Keshwaree Babooram and Ravin Narain

SECTION IV INORGANIC NANOMATERIALS BIOCONJUGATES (METALS,
METAL OXIDES--QUANTUM DOTS, IRON-OXIDE)

9 Gold Nanomaterials Bioconjugates 257

Qian Yang

10 Methods for Magnetic Nanoparticle Synthesis and
Functionalization 281

Mohammad H. El-Dakdouki, Kheireddine El-Boubbou, Jingguang Xia,
Herbert Kavunja, and Xuefei Huang

11 Quantum Dots Bioconjugates 315

Xiaoze Jiang, Meifang Zhu, and Ravin Narain

12 Silica Nanoparticle Bioconjugates 327

Yohei Kotsuchibashi, Mitsuhiro Ebara, and Ravin Narain

13 Polyhedral Oligomeric Silsesquioxanes (POSS) Bioconjugates
344

Weian Zhang, Zhenghe Zhang, and Lizhi Hong

SECTION V CELL-BASED, HYDROGELS/MICROGELS AND
GLYCO-BIOCONJUGATES

14 Cell-Based Bioconjugates 357

Mitsuhiro Ebara

15 Bioresponsive Hydrogels and Microgels 370

Xue Li and Michael J. Serpe

16 Conjugation Strategies Used for the Preparation of
Carbohydrate-Conjugate Vaccines 387

Rachel Hevey and Chang-Chun Ling

SECTION VI CHARACTERIZATION, PHYSICO-(BIO)CHEMICAL
PROPERTIES, AND APPLICATIONS OF BIOCONJUGATES

17 Properties and Characterization of Bioconjugates 417

Ali Faghihnejad, Jun Huang, and Hongbo Zeng

18 Physico-Chemical and Biochemical Properties of Bioconjugates
431

Marya Ahmed and Ravin Narain

19 Applications of Bioconjugates 444

Marya Ahmed and Ravin Narain

INDEX 457