Prolactin Secretion: A Multidisciplinary Approach

Prolactin Secretion: A Multidisciplinary Approach covers the proceedings of the 1982 symposium on the frontiers and perspective of prolactin secretion through a multidisciplinary approach, convened in Nabor Carrillo Hall of the Natural University of Mexico. The symposium represents a genuine interdisciplinary effort to provide insights into the complexities of prolactin.
Separating 24 manuscripts into chapters, this book first discusses studies on the molecular evolution of prolactin (PRL) and the related growth hormones and placental lactogens and the relevance of these studies for biological research on PRL, with particular emphasis on PRL secretion. Significant topics on the physiology, biochemistry, synthesis regulation, structure, function, glycoconjugates, gene expression control, regulatory, and control mechanisms of PRL and its secretion are considered in the subsequent chapters. This book also examines the action(s) of dopamine on the PRL-producing cells, the effects of his-pro diketopiperazine on PRL secretion, and the role of cellular phospholipids and the Ca2+-calmodulin system as modulators of PRL release. The effect of the suckling stimulus on the induction of PRL release in different reproductive states and the role of PRL in parental behavior in selected species of mammals and birds are also considered. The concluding chapters describe the morphologic features of abnormal lactotrophs, the in vivo and in vitro secretory activity exhibited by different types of pituitary adenomas and hyperprolactinemia.
This book serves as an important reference for a wide range of investigators and advanced medical students who are engaged in the study of basic and clinical prolactin physiology.

Contenu

Contributors
Preface
Acknowledgments
The Molecular Evolution of Prolactin and Related Hormones
Comparative Physiology of the Prolactin Cell
The Biochemistry and Physiology of Mouse Placental Lactogen
The Effect of Maternal-Fetal Interactions on Prolactin Secretion
Regulation of the Synthesis and Release of Decidual Prolactin
The Prolactin Cell: Structure and Function
Extracellular Glycoconjugates and Prolactin Secretion
Studies on the Control of Prolactin Gene Expression by Calcium and Hormones
Estrogen Effects on Prolactin Storage and Cell Growth in GH Cells
Molecular Mechanism of Prolactin Release from Pituitary Secretory Granules
Regulatory and Control Mechanisms of Prolactin Secretion Within the Pituitary of the Lactating Rat
Transduction of Dopamine and Vasoactive Intestinal Polypeptide Signals in Prolactin-Secreting Cells
Electrophysiological Approach of Stimulus-Secretion Coupling in Prolactin-Secreting Cells
Characterization of Anterior Pituitary Dopamine Receptors
Metabolism of Thyrotropin Releasing Hormone and Its Possible Relevance to Prolactin Secretion
On the Intracellular Mechanisms That Regulate Prolactin Secretion
Interaction of Estrogens with Dopamine and Calcium in the Regulation of Prolactin Release In Vivo
Control of the Multiphase Secretion of Prolactin in the Lactating Rat
Relationship Between Depletion and Release of Prolactin in the Lactating Rat: A Quantitative Analysis
Suckling-Induced Release of Prolactin in Nonlactating Rats
Prolactin and Parental Behavior Among Selected Species of Mammals and Birds
The Morphology of Abnormal Lactotrophs
Morphofunctional Analysis of Hormonal Secretion in Pituitary Neoplasia
Neuroendocrine Studies of Prolactin Secretion in Hyperprolactinemic States
Concluding Remarks
Index