Posttranslational covalent modifications of proteins

Posttranslational Covalent Modifications of Proteins focuses on the processes involved in the regulation of protein functions.
Partitioned into 21 chapters, the book starts with discussions on the perspectives and prospectives of posttranslational protein modifications; protein phosphorylation and neural and hormonal control of enzymes; and research on the Rous sarcoma virus. The text also looks at studies on phosphorylation, protein kinases, and protein acetylation. The studies show the different reactions of proteins when combined under varying conditions and controlled environments. Schematic representations are presented to validate the processes involved.
The book also presents experiments done on Vitamin K-dependent carboxylase from rat liver and cow. Lengthy discussions and diagrams are presented to give credence to the methodologies and results obtained. The text also focuses on studies on enzymatic activities in bacterial toxins and animals tissues.
The book is a vital source of data for readers interested in the processes, techniques, and methodologies involved in the modification of proteins.

Contenu

Contributors
Foreword
Preface
List of Speakers
Posttranslational Protein Modifications: Perspectives and Prospectives
Protein Phosphorylation and the Neural and Hormonal Control of Enzyme Activity
The Rous Sarcoma Virus-Transforming Gene Product: In Vitro Phosphorylation with ATP and GTP as Phosphate Donors
Calmodulin-Modulated Protein Phosphorylation
Characterization of Neural-Specific cAMP-Dependent Protein Kinase
Phospholipid Turnover as Transmembrane Signalling for Protein Phosphorylation and Platelet Activation
Histone HI Phosphorylation: Purification and General Properties of a Camp Independent Histone HI Kinase
HI Histone Phosphorylation: An Analysis of Different Phosphorylation Sites and Their Relationship to Chromosome Replication
Effects of Phosphorylation on the Recycling of Eukaryotic Initiation Factor 2 (eIF-2)
Affinity Probes for Protein Acetylation and Phosphorylation
Vitamin K-Dependent Carboxylase from Rat Liver
Studies on Vitamin K-Dependent Carboxylase from the Cow
Vitamin K-Dependent Carboxylase: Recent Studies of the Rat Liver Enzyme System
Utilizing Substrates with Modified Glutamyl Residues to Elucidate the Reaction Mechanism of the Vitamin K-Dependent 7-Glutamyl Carboxylase
Vitamin K-Dependent Carboxylase: A Heme Protein?
ADP-Ribosylation of Proteins: An Overview
NAD: Arginine ADP-Ribosyltransferases: Enzymatic Activities in Animal Cells and Bacterial Toxins
Mono- and Poly(ADP-Ribosylation) in Intact Cells
Protein ADP-Ribosylation in Response to DNA Damage: Effects of Mg2+ and Ca2+ on Auto ADP-Ribosylation
ADP-Ribosylation of the Regulatory Components of Adenylate Cyclase
Macromolecular Properties of Poly(ADP-Ribose) and the Regulation of Its Biosynthesis and Degradation in Permeabilized Rat Brain 9L-Gliosarcoma Cells
Index