Post-Transplant Lymphoproliferative Disorders

This disorder transcends multiple disciplines and demands a team approach to improve knowledge and treatment. The highly experienced internationally recognized authors have updated every section and added many new chapters, including some on genetic abnormalities in virus and host seen in PTLDs. In this successor edition, there is a completely new section on PTLDs after hematopoietic stem cell transplantation. The newest PTLD classifications and current treatment paradigms that reflect recently conducted international trials are fully incorporated. As technologies have advanced, this book provided state-of-the-art new diagnostic and prognostic information.

Post-Transplant Lymphoproliferative Disorders 2nd Edition is designed to be a valuable reference for oncologists and all transplant professionals, such as surgeons, nephrologists, cardiologists, hepatologists/gastroenterologists, pulmonologists, infectious disease specialists, pathologists, as well as interns andresidents in training in these specialists. It provides these professionals with comprehensive and up-to-date information that guides their management of transplant patients before and after transplant, with and without PTLD.

Auteur
Vikas R. DharnidharkaDivision of Pediatric Nephrology Hypertension and PheresisWashington University School of MedicineSt. Louis, MOUSA Michael GreenDepartments of Pediatrics and SurgeryUniversity of Pittsburgh School of MedicineUPMC Children's Hospital of PittsburghPittsburgh, PAUSA Steven A. WebberDepartment of PediatricsVanderbilt University School of MedicineNashville, TNUSA Ralf Ulrich TrappeDepartment of Hematology and OncologyDIAKO Ev. Diakonie-Krankenhaus BremenBremen, Germany

Résumé

Post-transplant lymphoproliferative disorders are a group of conditions that straddle the borders between infection and malignancy. They were very rare prior to the mid-1980s but now can be expected to develop in 1-10% of transplant recipients. While some cases are reversible with reduction in immunosuppression, more severe forms are indistinguishable from frank lymphomas.

This book sets out to cover in depth every aspect of these disorders, including both basic science and clinical topics. The epidemiology is reviewed, and careful attention is paid to the role of Epstein-Barr virus in their development. Clinical features are documented and clear guidance is provided on diagnosis, with thorough description of pathologic and imaging findings. Further chapters are devoted to treatment, prognosis, preventive and pre-emptive strategies, and organ-specific considerations.

The state-of-the-art information contained in this book will aid researchers as well as the many different professionals involved in caring for patients with post-transplant lymphoproliferative disorders. The comprehensive and detailed coverage will appeal to those who already have some expertise in the field, yet the book will also serve as an invaluable resource for beginners in transplantation.

Contenu

Introduction and History.- Definitions and Pathology of PTLD.- EBV Biology in the Pathogenesis of PTLD.- Host genetic mutations and expression analyses in PTLD.- Immune responses to EBV in the immunocompromised host.- Technical aspects of Epstein-Barr viral load assays.- Epidemiology of PTLD after SOT.- Clinical Features and Diagnostic Considerations.- Prognostic Factors.- Management of PTLD.- Prevention of Epstein - Barr virus Infection and Post-Transplant Lymphoproliferative Disorders Following Transplantation.- Epidemiology and Prognosis of PTLD after HSCT.- Clinical Presentations and Features of PTLD after Hematopoietic Stem Cell Transplantation.- Management of PTLD after HSCT.- Preventative and preemptive strategies for EBV infection and PTLD after hematopoietic stem cell transplantation.- Organ Specific issues of PTLD Kidney.- Liver.- Post-transplantation Lymphoproliferative Disorder in Intestinal Transplant Recipients.- PTLD After Heart Transplantation.- Lung Transplantation.- Research Priorities and Future Directions.