Neurotransmitters and Epilepsy

The idea for this book has evolved from our desire to present a conceptual approach to the study of neurotransmitters in epilepsy. Such an approach requires an understanding of the function of neurotransmitter systems in various experimental models of epilep­ sy. Toward this goal we have included in this book chapters on neurotransmitter systems in nine different epilepsy models. To com­ plete the coverage of this topic, there is a chapter on the role of selected neurotransmitters in the various types of human epilep­ sies. In the final chapter the editors integrated the neurotransmit­ ter data from the various epilepsy models into a matrix from which a better understanding of the function of these neurotransmitters in modulating epileptogenesis may be obtained. The information found in this book is not the result of a sym­ posium on this topic, but rather a review of available information on neurotransmitters in each of the experimental models. The evi­ dence is presented by knowledgeable researchers using these models. This approach gives a current, broader, and more thorough presentation of each of the topics. We therefore feel that this is not just a glimpse at the subject matter, but a panoramic view of the topic.

Contenu

Neurotransmitter Systems and Epilepsy: An Overview.- Epilepsy-Prone Mice: Genetically Determined Sound-Induced Seizures.- The Spontaneously Epileptic Mongolian Gerbil.- The Genetically Epilepsy-Prone Rat.- The Epileptic Chickens.- Biochemical and Pharmacologic Studies of Neurotransmitters in the Kindling Model.- In Vitro Models of Epilepsy.- Experimental Epilepsy Induced by Direct Topical Placement of Chemical Agents on the Cerebral Cortex.- Seizures Induced by Convulsant Drugs.- The Role of Neurotransmitters in Electroshock Seizure Models.- Neurotransmitters in Human Epilepsy.- Neurotransmitter Systems and the Epilepsy Models: Distinguishing Features and Unifying Principles.