Pharmaceutical Nanotechnology, 2 Volumes

Dieses Fachbuch legt den Schwerpunkt auf konkrete Methoden und die jüngsten Fortschritte bei der Anwendung von Nanotechnologie für die Entwicklung neuer medikamentöser Therapieansätze und die medizinische Diagnostik. Von den Grundlagen der Nanopharmazie, einschließlich Charakterisierung und Herstellungsverfahren, bis hin zur Rolle von Nanopartikeln und Wirkstoffen wird das Fachgebiet umfassend dargestellt. Anwendungsbeispiele beziehen sich auf Fragestellungen bei der Medikamentenentwicklung und die Übertragung auf die klinische Praxis, Marktchancen und Aspekte der industriellen Vermarktung. Die beschriebenen Anwendungen stammen aus der Behandlung von Krebserkrankungen und weiteren wichtigen Therapiebereichen wie Infektionskrankheiten und Dermatologie. Abgerundet wird das Fachbuch durch eine ausführliche Erörterung sicherheitsrelevanter, rechtlicher und gesellschaftlicher Fragen.
Geschrieben von einem erstklassigen Team von Herausgebern und Autoren, die zu den führenden Experten in Europa und den USA sowie zu den Pionieren der Nanopharmazie gehören.

Auteur
Jean Cornier is presently consultant to several companies in the areas of life science, new technologies and business development. He obtained his PhD from the University of Caen, France, and a MSc degree in pharmaceutical medicine from the University of Duisburg-Essen, Germany. Since 1986 he has worked in the space industry as expert in Materials and Life Science research and projects, was participant in space commercialisation initiatives supported by the European and German space agencies as well as in several EU-funded projects in biotechnology and civil security research.

Professor Arno Kwade is Head of the Center of Pharmaceutical Engineering and of the Institute of Particle Technology at the Technical University Braunschweig, Germany. After his PhD he worked nine years in industry as partner of a consulting firm for processing and handling of materials and as general manager of a medium-sized company active in materials processing. Professor Kwade is speaker of the European working party on comminution and classification and developed a course on nanomilling, taken by more than 1000 participants from different industries, among them many pharmaceutical companies.

Professor Andrew Owen holds a personal Chair in Molecular and Clinical Pharmacology at the University of Liverpool, UK. He is also affiliated to the MRC Centre for Drug Safety Science and the Wolfson Centre for Personalised Medicine. He is Chair of the British Society for Nanomedicine, is co-inventor of several patents related to nanomedicines and has contributed to over 150 publications and book chapters. He is co-founder of University commercial start-ups, a Fellow of the Royal Society of Biology, a Fellow of the British Pharmacological Society and member of the steering committee for the Academy of Pharmaceutical Sciences Nanomedicine Focus Group.

Marcel Van de Voorde has 40 years` experience in European Research Organisations including CERN-Geneva, European Commission, with 10 years at the Max Planck Institute in Stuttgart, Germany. For many years, he was involved in research and research strategies, policy and management, especially in European research institutions. He holds a Professorship at the University of Technology in Delft, the Netherlands, as well as multiple visiting professorships in Europe and worldwide. He holds a doctor honoris causa and various honorary Professorships.
He is senator of the European Academy for Sciences and Arts, in Salzburg and Fellow of the World Academy for Sciences. He is a Fellow of various scientific societies and has been decorated by the Belgian King. He has authored of multiple scientific and technical publications and co-edited multiple books in the field of nanoscience and nanotechnology.

Résumé
With its focus on concrete methods and recent advances in applying nanotechnology to develop new drug therapies and medical diagnostics, this book provides an overall picture of the field, from the fundamentals of nanopharmacy with the characterisation and manufacturing methods to the role of nanoparticles and substances. Actual examples of utilization include drug development issues, translation to the clinic, market prospects, and industrial commercialization aspects. The applications described are taken from cancer treatment as well as other major therapeutic areas, such as infectious diseases and dermatology. An in-depth discussion on safety, regulatory, and societal aspects rounds off the book.
Written by a top team of editors and authors composed of the leading experts in Europe and the USA who have pioneered the field of nanopharmacy!

Contenu

Foreword XXVII

Industrial Requirement on Nanopharmacy Research XXIX

Introduction XXXI

Volume 1

Part One Entry to the Nanopharmacy Revolution 1

1 History: Potential, Challenges, and Future Development in Nanopharmaceutical Research and Industry 3
Albertina Ariën and Paul Stoffels

1.1 Nanopharmaceuticals in Cancer Therapy 4

1.2 Nanoparticles Actively Using the Host Machinery 5

1.3 Nanopharmaceuticals for Oral Administration and Long-Acting Injectable Therapy 8

1.4 Bridging Future Nanomedicines to Commercialization 10

1.5 Future Outlook 11

Acknowledgments 12

References 12

2 Nanoscale Drugs: A Key to Revolutionary Progress in Pharmacy and Healthcare 17
Simon Sebastian Raesch, Marina Poettler, Christoph Alexiou, and Claus-Michael Lehr

2.1 Introduction 17

2.2 Nanopharmacy Concepts to Improve the Safety and Efficacy of Medicines 20

2.3 Technical Realization of Nanopharmaceuticals 30

2.4 Safety of Nanopharmaceuticals 34

2.5 Present and Future of Nanopharmacy 35

References 37

3 The Emergence of Nanopharmacy: From Biology to Nanotechnology and Drug Molecules to Nanodrugs 43
Marilena Hadjidemetriou, Zahraa Al-Ahmady, Mariarosa Mazza, and Kostas Kostarelos

3.1 Introduction 43

3.2 First Generation of Nanopharmaceuticals: From Drug Molecules to Nanodrugs 45

3.3 Conclusion 55

References 56

4 Understanding and Characterizing Functional Properties of Nanoparticles 63
Ester Polo, Valentina Castagnola, and Kenneth A. Dawson

4.1 Introduction 63

4.2 The Approach to Characterization 70

References 77

5 Omics-Based Nanopharmacy: Powerful Tools Toward Precision Medicine 81
Daniel Rosenblum and Dan Peer

5.1 Introduction 81

5.2 Precision Medicine 82

5.3 OMICS New Era in Understanding Pathology 86

5.4 Nanomedicine 90

5.5 Future Outlook 93

Acknowledgments 96

References 96

Part Two Fundamentals of Nanotechnology in Pharmacy 101

6 Nanostructures in Drug Delivery 103
Salma Nabil Tammam and Alf Lamprecht

6.1 Introduction 103

6.2 Nanocarrier Classification 103

6.2.1 Inorganic Nanostructures 104

6.3 Drug Loading and Release 116

6.4 General Discussion and Conclusions 123

References 124

7 Characterization Methods: Physical and Chemical Characterization Techniques 135
Sven Even F. Borgos

7.1 The Need for Nanomedicine-Specific Characterization 135

7.2 The Assay Cascade: From Basic Properties to Complex Interactions 136

7.3 Physicochemical Characterization of Pristine Nanoparticles 137

7.4 Characterization of Nanoparticles in the Biological Environment 144

7.5 Conclusions and Future Outlook 149

References 150

8 Nanoparticle Characterization Methods: Applications of Synchrotron and Neutron Radiation 157
Martha Brennich, Marité Cardenas, Hiram Castillo-Michel, Marine Cotte, V. Trevor Forsyth, Michael Haertlein, Simon A. J. Kimber, Geraldine Le Duc, Edward P. Mitchell, Adam Round, Murielle Salome, and Michael Sztucki

8.1 Advanced Characterization: Synchrotron Light and Neutron Sources 157

8.2 Application Examples 159

8.3 Going Beyond Characterization Using Synchrotron X-rays: Nanop…