The Physical Basis of Biochemistry

The Physical Basis of Biochemistry: Solutions Manual to the Second Edition offers solutions to the problem sets from the second edition of The Physical Basis of Biochemistry. The Physical Basis of Biochemistry is an introduction to the philosophy and practice of an interdisciplinary field in which biological systems are explored using the quantitative perspective of the physical scientist. As with the first edition, the idea that a fundamental understanding of the basic physical principles underlying chemical biological systems is vital remains the focus of this second edition. This new edition of The Physical Basis of Biochemistry has substantial new material added with respect to models at the simple molecular level (including van der Waals gases and virial treatments) which is tied to coverage of models of polymer thermo-dynamics. The second edition is partitioned into five sections: the central concept that science is a way of looking at the world; the physical under-pinnings of biophysical chemistry with an emphasis first on energy, work and forces of biological importance; exploring how models applicable to molecular biophysics are constructed; the three-dimensional potential energy surface put into motion; and a succinct discussion of the bio-physical methods used to evaluate structure and function in biological systems. Additionally, a section of appendices continues to serve the purpose of presenting some review information and certain topics in detail. The Physical Basis of Biochemistry will be of interest to quantitatively-oriented biologists as well as aspiring chemists, physicists, and engineers with an interest in biological systems.

Auteur

Kevin Hallock, Ph.D., is a researcher and instructor in the Department of Anatomy and Neurobiology at the Boston University School of Medicine in Boston, Masschusetts, where he teaches biostatistics, an graduate course on the science of disasters, and co-teaches biophysical chemistry and modeling courses with Dr. Bergethon. His research interests include the impact of antimicrobial peptide on phospholipid bilayers, solid-state NMR and magnetic resonance imaging characterization of crystalline solids, atherosclerotic plaque formation, magnetic resonance microscopy of arthropods, the impact of chronic Hg exposure on aging, and the role cell membrane biophysics play in the fundamental processes of neurophysics. Peter Bergethon, MD is the Head of the Neuroscience Interdisciplinary Modeling and Simulation Center (NIMS Center), the Laboratory for Intelligence Modeling and Neurophysics and a member of the faculty in both the Departments of Anatomy/Neurobiology and Biochemistry at Boston University School of Medicine. His research spirals around a core question: "What is the physical and systemic basis for creativity and intelligent behavior and how could such behavior be practically constructed or reconstructed?" Dr. Bergethon is also an active member of the American Academy of Neurology from which he received the Founder's Award , the Electrochemical, Biophysical, American Chemical Societies, the Society for Neuroscience and the American Society of Biochemistry and Cellular Biology.

Texte du rabat

advanced undergraduate/beginning graduate level students and would be applied to courses focusing on three different areas:

Foundations of molecular biophysics Macromolecular structure and assembly Methods in physical biochemistry

Contenu

PART I: Principles of Biophysical Inquiry Chapter 1 Philosophy and Practice of Biophysical Study Chapter 2 Overview of the Biological System Under Study - Descriptive Models Chapter 3 Physical Thoughts, Biological Systems - The application of modeling principles to understanding biological systems Chapter 4 Probability and Statistics PART II: Foundations Chapter 5 Physical Principles: Energy - The Prime Observable Chapter 6 Biophysical Forces in Molecular Systems Chapter 7 An Introduction to Quantum Mechanics Chapter 8 Chemical Principles Chapter 9 Measuring the Energy of a System: Energetics and the First Law of Thermodynamics Chapter 10 Entropy and the Second Law of Thermodynamics Chapter 11 Which Way Did That System Go? The Gibbs Free Energy Chapter 12 The Thermodynamics of Phase Equilibria PART III: Building a Model of Biomolecular Structure Chapter 13 Water: A Unique Structure, A Unique Solvent Chapter 14 Ion-Solvent Interactions Chapter 15 Ion-Ion Interactions Chapter 16 Lipids in Aqueous Solution Chapter 17 Macromolecules in Solution Chapter 18 Molecular Modeling - Mapping Biochemical State Space Chapter 19 The Electrified Interphase PART IV: Function and Action Biological State Space Chapter 20 Transport and Kinetics: Processes Not at Equilibrium Chapter 21 Flow in a Chemical Potential Field: Diffusion Chapter 22 Flow in an Electrical Field: Conduction Chapter 23 Forces Across Membranes Chapter 24 Kinetics - Chemical Kinetics Chapter 25 Bioelectrochemistry - Charge Transfer in Biological Systems PART V: Methods for the Measuring Structure and Function Chapter 26 Separation and Characterization of Biomolecules Based on Macroscopic Properties Chapter 27 Determining Structure by molecular interactions with photons: Electronic Spectroscopy Chapter 28 Determining Structure by molecular interactions with photons: Scattering Phenomena Chapter 29 Analysis of Structure - Microscopy PART VI: Physical Constants Physical Constants