Routes to Essential Medicines

This comprehensive workbook helps readers become familiar with the structures and synthetic challenges associated with nearly 300 essential medicines and gain the skills needed for pharmaceutical development.

• Highlights nearly three hundred medicines on the latest World Health Organization (WHO) Model List of Essential Medicines and their manufacturing routes

• Features exercises that equip students with the skills necessary to solve similar real-world problems

• Includes a retrosynthetic analysis for each commodity chemical and supplies an extensive list of key journal and information sites and a library of reagents, solvents, and conditions for many common organic reactions

Auteur

Peter J. Harrington, PhD, is the owner and primary consultant for Better Pharma Processes LLC, Boulder, Colorado, USA. Dr. Harrington is a pharmaceutical process design and development expert with more than twenty years' experience in timely process innovation for major pharmaceuticals. His publications include a book on pharmaceutical process chemistry for synthesis and several articles on organic and medicinal chemistry.

Contenu

Introduction xix

A 1

Abacavir 1

Acetazolamide 3

Acetylcysteine 4

Acetylsalicylic Acid 4

Acyclovir 5

Albendazole 6

Allopurinol 7

Amidotriazoate 8

Amikacin 9

Amiloride 11

4-Aminosalicylic Acid 12

Amiodarone 13

Amitriptyline 15

Amlodipine 16

Amodiaquine 17

Amoxicillin 18

Ampicillin 20

Anastrozole 21

Artemether 23

Artesunate 24

Ascorbic Acid 26

Atazanavir 27

Atracurium Besylate 29

Atropine 32

Azathioprine 34

Azithromycin 35

Aztreonam 37

B 40

Beclomethasone Dipropionate 40

Bedaquiline 45

Bendamustine 47

Benznidazole 49

Benzoyl Peroxide 50

Benzyl Benzoate 51

Betamethasone 52

Bicalutamide 56

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Biperiden 57

Bisoprolol 58

Budesonide 59

Bupivacaine 62

C 63

Caffeine 63

Calcium Folinate/Folinic Acid 64

Capecitabine 65

Carbamazepine 67

Cefalexin 68

Cefazolin 69

Cefepime 71

Cefixime 73

Cefotaxime 75

Ceftaroline 77

Ceftazidime 81

Ceftriaxone 84

Chlorambucil 86

Chloramphenicol 87

Chlorhexidine 89

Chloroquine 90

Chloroxylenol 91

Chlorpromazine 92

Ciprofloxacin 93

Cisplatin, Carboplatin, Oxaliplatin 94

Clarithromycin 97

Clindamycin 99

Clofazimine 100

Clomifene 101

Clomipramine 102

Clopidogrel 103

Cloxacillin 105

Clotrimazole 106

Clozapine 107

Codeine 108

Colecalciferol 109

Cyclizine 112

Cyclophosphamide 113

Cycloserine 114

Cytarabine 114

D 116

Dacarbazine 116

Daclatasvir 117

Dapsone 119

Darunavir 120

Dasabuvir 122

Dasatinib 124

Delamanid 126

Desmopressin 129

Dexamethasone 131

Diazepam 136 ...